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ClinicalTrials.gov 3 recruiting now official registry

Myelofibrosis (MF) clinical trials

3 of 7 indexed Myelofibrosis (MF) trials are currently recruiting.

7 US clinical trials · 3 currently recruiting

Myelofibrosis (MF) is the subject of 7 registered US clinical trials on ClinicalTrials.gov, 3 of them currently open to new participants. 2 are in Phase 3-4 (later-stage) and 4 in Phase 1-2 (earlier-stage). The most active sponsor is AbbVie, running 4 of these trials.

The research picture

Myelofibrosis (MF) has 7 registered US clinical trials, 3 of them open to new participants right now, about 43% of the total.

3
recruiting participants now
43%
of trials open to enrollment
2
in Phase 3–4 (later-stage)
4
top sponsor: AbbVie
Phase 12Phase 22Phase 32

Active & Recent Trials

7 total, page 1 of 1

RECRUITING 5,000 participants

MPN PROGRESSion Registry: Observational Study Tracking Symptoms, Treatments, and Disease Progression in People With Myeloproliferative Neoplasms (MPNs)

MPN Research Foundation

NCT07362225

RECRUITING Phase 1 66 participants

Phase I/II Clinical Trial of Axatilimab, a CSF1R Monoclonal Antibody, in Combination With Ruxolitinib as Therapy for Patients With Myelofibrosis (MF) and Chronic Myelomonocytic Leukemia (CMML)

M.D. Anderson Cancer Center

NCT07128381

RECRUITING Phase 2 54 participants

MethoTRExATE in MyelOpRolifErative Neoplasms (TREATMORE) Trial

Icahn School of Medicine at Mount Sinai

NCT06541249

ACTIVE NOT RECRUITING Phase 3 330 participants

Study of Oral Navitoclax Tablet in Combination With Oral Ruxolitinib Tablet Versus Best Available Therapy to Assess Change in Spleen Volume in Adult Participants With Relapsed/Refractory Myelofibrosis

AbbVie

NCT04468984

ACTIVE NOT RECRUITING Phase 1 21 participants

Safety and Tolerability Study of Oral ABBV-744 Tablet Alone or in Combination With Oral Ruxolitinib Tablet or Oral Navitoclax Tablet in Adult Participants With Myelofibrosis

AbbVie

NCT04454658

COMPLETED Phase 3 252 participants

Study of Oral Navitoclax Tablet In Combination With Oral Ruxolitinib Tablet When Compared With Oral Ruxolitinib Tablet To Assess Change In Spleen Volume In Adult Participants With Myelofibrosis

AbbVie

NCT04472598

COMPLETED Phase 2 191 participants

A Study Evaluating Tolerability and Efficacy of Navitoclax Alone or in Combination With Ruxolitinib in Participants With Myelofibrosis

AbbVie

NCT03222609

Phase Distribution

PhaseTrial count
Phase 1 2
Phase 2 2
Phase 3 2

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Myelofibrosis (MF) Trial Landscape

7 indexed Myelofibrosis (MF) studies · 3 recruiting (43%).

Phase mix: 2 late (III/IV) vs 4 early (I/II).

Top sponsor: AbbVie (4 trials), 3 others listed. 7 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Myelofibrosis (MF)?

PlainTrial tracks 7 US clinical trials for Myelofibrosis (MF), of which 3 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Myelofibrosis (MF)?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.