Medical Information Only. Consult your healthcare provider before considering clinical trial enrollment.
MPS I: early-phase trial registry
3 of 3 indexed MPS I trials are currently recruiting, with more weight in Phase 1-2.
Corpus placement: #5,209 of 28,707 conditions by registered trial count.
3 US clinical trials · 3 currently recruiting · #5,209 of 28,707 conditions by registered trial count
MPS I: 3 US clinical trials tracked, 3 recruiting.
MPS I is the subject of 3 registered US clinical trials on ClinicalTrials.gov, 3 of them currently open to new participants. 0 are in Phase 3-4 (later-stage) and 1 in Phase 1-2 (earlier-stage). The most active sponsor is Children's Hospital of Orange County, running 1 of these trials.
Enrollment posture brief
Registry condition mps-i
OPEN 3 | RECR 100% | LATE 0 | EARLY 1 | RANK #5209 | SPON 1
Volume-matched condition peers
Nearest open-share peer: Aortic Arch Aneurysm (100% recruiting · 5 trials)
MPS I lists 3 open slots (100% of 3 indexed trials). Peers are matched on registered volume, not therapeutic-area browse lists. How peer matching works →
Key findings
What ClinicalTrials.gov does not surface for MPS I on its own pages , computed from the registry mirror as of 2026-08-08. Each line carries its own denominator so it can be quoted as it stands.
-
MPS I is recruiting above its size-band peers.
3 of 3 indexed trials (100%) are open to enrollment, against a 46.5% average across 27,806 conditions with fewer than 20 trials. The peer set uses the same ClinicalTrials.gov-derived counts as this page.
Open and recent trials
3 total, page 1 of 1
Longitudinal Study of Neurodegenerative Disorders
University of Pittsburgh
NCT03333200
Cardiac Structure and Function in MPS
Children's Hospital of Orange County
NCT07361536
PEARL (PrEnAtal Enzyme Replacement Therapy for Lysosomal Storage Disorders)
University of California, San Francisco
NCT04532047
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 1 |
Top Sponsors
Named interventions
Most-linked intervention names on MPS I records (sponsor-reported on ClinicalTrials.gov). Counts are trial links, not unique products.
US sites by state
Facility locations filed on MPS I trials. A trial with sites in several states counts in each.
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Related
What to do with this MPS I page
3 registered trials, 3 currently recruiting, is a starting point for a conversation, not a diagnosis or a recommendation.
- 3 MPS I trials are currently recruiting, check eligibility criteria before contacting a site. Browse recruiting trials
- Children's Hospital of Orange County sponsors the most MPS I trials on record, review their full trial history before evaluating a specific study. See Children's Hospital of Orange County's trials
- Bring the specific trial ID (NCT number) to your own doctor before enrolling, this page is a directory, not medical guidance. Read the trial-finding guide
Trial and recruiting counts reflect ClinicalTrials.gov registry status as of the data vintage above; individual trial eligibility and enrollment status can change.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This MPS I condition card totals 3 registered trials; most-linked intervention Aldurazyme (laronidase); top US site state California. See our editorial standards & corrections policy, the methodology behind these numbers, the data changelog, or report a data error.