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NCT07361536 · ClinicalTrials.gov registry record
Cardiac Structure and Function in MPS
A clinical trial of MPS IVA and MPS I, sponsored by Children's Hospital of Orange County.
- Recruiting
- Registry status
- 240
- Enrollment target
- 3
- Study locations
NCT07361536: Recruiting study of MPS IVA and MPS I, sponsored by Children's Hospital of Orange County.
NCT07361536 is a study of MPS IVA and MPS I that is actively recruiting participants, run by Children's Hospital of Orange County. The registered enrollment target is 240 participants, above the 21-participant average among 5 other MPS IVA trials with a reported enrollment target (1043% higher). The trial reports 3 study locations across 3 states. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT07361536, a study of MPS IVA and MPS I, is actively recruiting participants, sponsored by Children's Hospital of Orange County.
- RECRUITING
- Registry status
- 240 participants
- Enrollment target
- 3
- Study locations
Study Summary
The purpose of this study is to better understand how heart and blood vessel problems develop in people with Mucopolysaccharidosis (MPS). The investigators are looking at certain substances in the body called GAGs and proteoglycans to see how they affect the heart. The investigators also want to find reliable blood and urine markers that can help us track heart health and guide future treatments. This study aims to answer two main questions: 1. Do people with MPS show faster changes in their blood vessels over time (such as thickening or stiffening of the carotid artery) compared to people without MPS? 2. Do people with MPS have higher levels of certain proteins in their blood (such as clusterin and inflammatory markers) that are linked to blood vessel changes? What participants will do? Participants will complete the following tests once a year for 4 years: * Carotid ultrasound: an imaging test that looks at the blood vessels in the neck. * Echocardiogram: an ultrasound of the heart. * Blood draw * Urine collection These tests help the investigators track changes in heart and blood vessel health over time.
Primary Outcome
1\) We aim to annually assess cardiac and carotid structure and function utilizing ultrasonography, in participants with mucopolysaccharidoses and matched control participants
Conditions Studied
Study Locations (3)
California
- Children'S Hospital of Orange County - Orange
Minnesota
- University of Minnesota - Minneapolis
Missouri
- Saint Louis University - St Louis
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 240 participants |
| Start Date | 2025-09-01 |
| Est. Completion | 2030-04-30 |
What NCT07361536 shows while recruiting
NCT07361536 is an observational study that tracks outcomes without assigning an intervention. The registered 240 participants enrollment target is mid-sized for trials with a published cap, above the 21-participant average among 5 other MPS IVA trials with a reported enrollment target (1043% higher).
The record links to 3 conditions, with MPS IVA appearing as the primary indexed condition, and to 0 interventions.
NCT07361536 reports a single indexed study location in California, Minnesota, Missouri.
Frequently Asked Questions
What is clinical trial NCT07361536 about?
NCT07361536 is a clinical study titled "Cardiac Structure and Function in MPS". The purpose of this study is to better understand how heart and blood vessel problems develop in people with Mucopolysaccharidosis (MPS). The investigators are looking at certain substances in the body called GAGs and proteoglycans to see how they affect the heart. The investigators also want to fin...
What is the current status of trial NCT07361536?
This trial is currently recruiting. The enrollment target is 240 participants. The study started on 2025-09-01. Estimated completion is 2030-04-30.
What conditions does trial NCT07361536 study?
This clinical trial studies the following conditions: MPS IVA, MPS I, MPS - Mucopolysaccharidosis.
Who is sponsoring clinical trial NCT07361536?
This trial is sponsored by Children's Hospital of Orange County, which has 13 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT07361536 being conducted?
This trial has 3 study locations across California, Minnesota, Missouri. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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