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ClinicalTrials.gov 7 recruiting now official registry

Metastatic Malignant Neoplasm in the Liver clinical trials

7 of 14 indexed Metastatic Malignant Neoplasm in the Liver trials are currently recruiting.

14 US clinical trials · 7 currently recruiting

Metastatic Malignant Neoplasm in the Liver is the subject of 14 registered US clinical trials on ClinicalTrials.gov, 7 of them currently open to new participants. 2 are in Phase 3-4 (later-stage) and 9 in Phase 1-2 (earlier-stage). The most active sponsor is M.D. Anderson Cancer Center, running 7 of these trials.

The research picture

Metastatic Malignant Neoplasm in the Liver has 14 registered US clinical trials, 7 of them open to new participants right now, about 50% of the total.

7
recruiting participants now
50%
of trials open to enrollment
2
in Phase 3–4 (later-stage)
7
top sponsor: M.D. Anderson Cancer Center
Phase 15Phase 24Phase 31Phase 41

Active & Recent Trials

14 total, page 1 of 1

RECRUITING Phase 3 408 participants

Testing Pump Chemotherapy in Addition to Standard of Care Chemotherapy Versus Standard of Care Chemotherapy Alone for Patients With Unresectable Colorectal Liver Metastases: The PUMP Trial

ECOG-ACRIN Cancer Research Group

NCT05863195

RECRUITING Phase 2 141 participants

Testing the Use of Chemotherapy After Surgery for High-Risk Pancreatic Neuroendocrine Tumors

SWOG Cancer Research Network

NCT05040360

RECRUITING Phase 2 140 participants

Short Stitch Versus Traditional Suture for the Prevention of Incisional Hernia After Open Hepatectomy

M.D. Anderson Cancer Center

NCT04982653

RECRUITING NA 70 participants

An Investigational Scan (Intravoxel Incoherent Motion Diffusion Weighted Imaging) for the Evaluation of Colorectal Cancer Liver Metastases Treatment Response

M.D. Anderson Cancer Center

NCT04796818

RECRUITING Phase 1 40 participants

Phase I/II Randomized Study of NBTXR3 Activated by Abscopal or RadScopal Radiation in Combination With Immunotherapy (Anti-PD-1/L-1) for Patients With Advanced Solid Malignancies

M.D. Anderson Cancer Center

NCT05039632

RECRUITING Phase 1 36 participants

AU409 for the Treatment of Advanced Primary Liver Cancers or Solid Tumor With Liver Metastatic Disease

University of Southern California

NCT05791448

RECRUITING Phase 4 6 participants

Surgical Debulking Prior to Peptide Receptor Radionuclide Therapy in Well Differentiated Gastroenteropancreatic Neuroendocrine Tumors

Vanderbilt-Ingram Cancer Center

NCT06016855

ACTIVE NOT RECRUITING NA 100 participants

Contrast-enhanced MRI in Detecting Benign and Malignant Liver Lesions

M.D. Anderson Cancer Center

NCT02156739

ACTIVE NOT RECRUITING Phase 1 38 participants

Combination Chemotherapy and Bevacizumab With the NovoTTF-100L(P) System in Treating Participants With Advanced, Recurrent, or Refractory Hepatic Metastatic Cancer

M.D. Anderson Cancer Center

NCT03203525

ACTIVE NOT RECRUITING Phase 1 36 participants

Radiation Therapy in Treating Patients With Hepatocellular Carcinoma, Cholangiocarcinoma, or Liver Metastasis Who Have Impaired Liver Function

M.D. Anderson Cancer Center

NCT02626312

ACTIVE NOT RECRUITING Phase 2 32 participants

Pembrolizumab With Liver-Directed or Peptide Receptor Radionuclide Therapy for Neuroendocrine Tumors and Liver Metastases

Nicholas Fidelman, MD

NCT03457948

ACTIVE NOT RECRUITING Phase 2 28 participants

Transarterial Chemoembolization for the Treatment of Uveal Melanoma With Liver Metastases

Thomas Jefferson University

NCT04728633

COMPLETED 75 participants

4D PET/CT in Diagnosing Participants With Lung and Colorectal Cancer With Liver and Lung Metastasis

M.D. Anderson Cancer Center

NCT00862680

COMPLETED Phase 1 46 participants

Trametinib in Treating Patients With Advanced Cancer With or Without Hepatic Dysfunction

National Cancer Institute (NCI)

NCT02070549

Phase Distribution

PhaseTrial count
Phase 1 5
Phase 2 4
Phase 3 1
Phase 4 1

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Metastatic Malignant Neoplasm in the Liver Trial Landscape

14 indexed Metastatic Malignant Neoplasm in the Liver studies · 7 recruiting (50%).

Phase mix: 2 late (III/IV) vs 9 early (I/II).

Top sponsor: M.D. Anderson Cancer Center (7 trials), 7 others listed. 14 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Metastatic Malignant Neoplasm in the Liver?

PlainTrial tracks 14 US clinical trials for Metastatic Malignant Neoplasm in the Liver, of which 7 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Metastatic Malignant Neoplasm in the Liver?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.