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ClinicalTrials.gov 7 recruiting now official registry

Metastatic Malignant Neoplasm in the Bone clinical trials

7 of 17 indexed Metastatic Malignant Neoplasm in the Bone trials are currently recruiting.

17 US clinical trials · 7 currently recruiting

Metastatic Malignant Neoplasm in the Bone is the subject of 17 registered US clinical trials on ClinicalTrials.gov, 7 of them currently open to new participants. 3 are in Phase 3-4 (later-stage) and 9 in Phase 1-2 (earlier-stage). The most active sponsor is National Cancer Institute (NCI), running 5 of these trials.

The research picture

Metastatic Malignant Neoplasm in the Bone has 17 registered US clinical trials, 7 of them open to new participants right now, about 41% of the total.

7
recruiting participants now
41%
of trials open to enrollment
3
in Phase 3–4 (later-stage)
5
top sponsor: National Cancer Institute (NCI)
Phase 13Phase 26Phase 33

Active & Recent Trials

17 total, page 1 of 1

RECRUITING 1,500 participants

Collecting and Studying Blood and Tissue Samples From Patients With Locally Recurrent or Metastatic Prostate or Bladder/Urothelial Cancer

University of Washington

NCT01050504

RECRUITING Phase 3 280 participants

Comparing Radiation Therapy to Usual Care for Patients With High-Risk Bone Asymptomatic Metastases, PREEMPT Trial

NRG Oncology

NCT06745024

RECRUITING NA 100 participants

Low-Dose Radiotherapy in Treating Painful Bone Metastases in Patients With Multiple Myeloma

University of Southern California

NCT03858205

RECRUITING Phase 1 90 participants

Radiation Medication (Radium-223 Dichloride) Versus Radium-223 Dichloride Plus Radiation Enhancing Medication (M3814) Versus Radium-223 Dichloride Plus M3814 Plus Avelumab (a Type of Immunotherapy) for Advanced Prostate Cancer Not Responsive to Hormonal Therapy

National Cancer Institute (NCI)

NCT04071236

RECRUITING 48 participants

Impact of DNA Repair Pathway Alterations on Sensitivity to Radium-223 in Bone Metastatic Castration-resistant Prostate Cancer

University of Washington

NCT04489719

RECRUITING NA 40 participants

Cryoablation Combined With Stereotactic Body Radiation Therapy for the Treatment of Painful Bone Metastases, the CROME Trial

M.D. Anderson Cancer Center

NCT04693377

RECRUITING Phase 1 24 participants

Biology-Guided Radiation Therapy for the Treatment of Patients With Bone Metastases

City of Hope Medical Center

NCT06549478

ACTIVE NOT RECRUITING Phase 3 1,175 participants

Immunotherapy With Nivolumab and Ipilimumab Followed by Nivolumab or Nivolumab With Cabozantinib for Patients With Advanced Kidney Cancer, The PDIGREE Study

National Cancer Institute (NCI)

NCT03793166

ACTIVE NOT RECRUITING Phase 3 312 participants

Combination Chemotherapy With or Without Ganitumab in Treating Patients With Newly Diagnosed Metastatic Ewing Sarcoma

National Cancer Institute (NCI)

NCT02306161

ACTIVE NOT RECRUITING Phase 2 134 participants

Testing the Addition of a New Anti-cancer Drug, Radium-223 Dichloride, to the Usual Treatment (Cabozantinib) for Advanced Renal Cell Cancer That Has Spread to the Bone, RadiCaL Study

National Cancer Institute (NCI)

NCT04071223

ACTIVE NOT RECRUITING Phase 2 70 participants

Testing the Addition of Radium Therapy (Radium-223 Dichloride) to the Usual Chemotherapy Treatment (Paclitaxel) for Advanced Breast Cancer That Has Spread to the Bones

National Cancer Institute (NCI)

NCT04090398

ACTIVE NOT RECRUITING Phase 2 20 participants

Salvage Oligometastasectomy and Radiation Therapy in Recurrent Prostate Cancer

University of Utah

NCT03796767

ACTIVE NOT RECRUITING Phase 2 2 participants

Efficacy of Ra-223 in PSMA PET Optimally Selected Patients

University of California, San Francisco

NCT05924672

COMPLETED NA 102 participants

Palliative Radiation Therapy in Reducing Pain in Patients With Bone Metastasis

Wake Forest University Health Sciences

NCT02699697

COMPLETED Phase 2 36 participants

Genetic and Molecular Mechanisms in Assessing Response in Patients With Prostate Cancer Receiving Enzalutamide Therapy

OHSU Knight Cancer Institute

NCT02099864

COMPLETED Phase 2 31 participants

Durvalumab and Tremelimumab in Treating Chemotherapy Naive Patients With Metastatic Castration-Resistant Prostate Cancer

M.D. Anderson Cancer Center

NCT03204812

COMPLETED Phase 1 20 participants

Nivolumab and Ipilimumab and Stereotactic Body Radiation Therapy in Treating Patients With Salivary Gland Cancers

University of Washington

NCT03749460

Phase Distribution

PhaseTrial count
Phase 1 3
Phase 2 6
Phase 3 3

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Metastatic Malignant Neoplasm in the Bone Trial Landscape

17 indexed Metastatic Malignant Neoplasm in the Bone studies · 7 recruiting (41%).

Phase mix: 3 late (III/IV) vs 9 early (I/II).

Top sponsor: National Cancer Institute (NCI) (5 trials), 9 others listed. 17 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Metastatic Malignant Neoplasm in the Bone?

PlainTrial tracks 17 US clinical trials for Metastatic Malignant Neoplasm in the Bone, of which 7 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Metastatic Malignant Neoplasm in the Bone?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.