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ClinicalTrials.gov 6 recruiting now official registry

Metastatic HER2-Negative Breast Carcinoma clinical trials

6 of 9 indexed Metastatic HER2-Negative Breast Carcinoma trials are currently recruiting.

9 US clinical trials · 6 currently recruiting

Metastatic HER2-Negative Breast Carcinoma is the subject of 9 registered US clinical trials on ClinicalTrials.gov, 6 of them currently open to new participants. 0 are in Phase 3-4 (later-stage) and 9 in Phase 1-2 (earlier-stage). The most active sponsor is National Cancer Institute (NCI), running 3 of these trials.

The research picture

Metastatic HER2-Negative Breast Carcinoma has 9 registered US clinical trials, 6 of them open to new participants right now, about 67% of the total.

6
recruiting participants now
67%
of trials open to enrollment
0
in Phase 3–4 (later-stage)
3
top sponsor: National Cancer Institute (NCI)
Phase 12Phase 27

Active & Recent Trials

9 total, page 1 of 1

RECRUITING Phase 2 2,900 participants

Targeted Therapy Directed by Genetic Testing in Treating Patients With Locally Advanced or Advanced Solid Tumors, The ComboMATCH Screening Trial

National Cancer Institute (NCI)

NCT05564377

RECRUITING Phase 2 160 participants

Circulating Tumor DNA to Guide Changes in Standard of Care Chemotherapy

Vanderbilt-Ingram Cancer Center

NCT05770531

RECRUITING Phase 2 60 participants

Functional Imaging in Prediction of Response to Abemaciclib for Advanced Hormone Receptor-Positive, HER2-Negative Breast Cancer

University of Washington

NCT06179303

RECRUITING Phase 2 40 participants

A Vaccine (STEMVAC) With Standard Endocrine-Based Therapy or Chemotherapy for the Treatment of Metastatic Hormone Receptor Positive, HER2 Negative Breast Cancer

University of Washington

NCT07112053

RECRUITING Phase 2 35 participants

Adaptive Therapy With Capecitabine for Treatment of Metastatic ER Positive, HER2 Negative Breast Cancer

Mayo Clinic

NCT06525766

RECRUITING Phase 1 25 participants

Personalized Neo-Antigen Peptide Vaccine for the Treatment of Stage IIIC-IV Melanoma, Hormone Receptor Positive HER2 Negative Metastatic Refractory Breast Cancer or Stage III-IV Non-Small Cell Lung Cancer

Fred Hutchinson Cancer Center

NCT05098210

ACTIVE NOT RECRUITING Phase 2 70 participants

Testing the Addition of Radium Therapy (Radium-223 Dichloride) to the Usual Chemotherapy Treatment (Paclitaxel) for Advanced Breast Cancer That Has Spread to the Bones

National Cancer Institute (NCI)

NCT04090398

ACTIVE NOT RECRUITING Phase 2 44 participants

Testing Sacituzumab Govitecan Therapy in Patients With HER2-Negative Breast Cancer and Brain Metastases

SWOG Cancer Research Network

NCT04647916

ACTIVE NOT RECRUITING Phase 1 24 participants

Testing the Addition of Copanlisib to Usual Treatment (Fulvestrant and Abemaciclib) in Metastatic Breast Cancer

National Cancer Institute (NCI)

NCT03939897

Phase Distribution

PhaseTrial count
Phase 1 2
Phase 2 7

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Metastatic HER2-Negative Breast Carcinoma Trial Landscape

9 indexed Metastatic HER2-Negative Breast Carcinoma studies · 6 recruiting (67%).

Phase mix: 0 late (III/IV) vs 9 early (I/II).

Top sponsor: National Cancer Institute (NCI) (3 trials), 5 others listed. 9 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Metastatic HER2-Negative Breast Carcinoma?

PlainTrial tracks 9 US clinical trials for Metastatic HER2-Negative Breast Carcinoma, of which 6 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Metastatic HER2-Negative Breast Carcinoma?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.