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ClinicalTrials.gov 9 recruiting now official registry

Metastatic Clear Cell Renal Cell Carcinoma clinical trials

9 of 14 indexed Metastatic Clear Cell Renal Cell Carcinoma trials are currently recruiting.

14 US clinical trials · 9 currently recruiting

Metastatic Clear Cell Renal Cell Carcinoma is the subject of 14 registered US clinical trials on ClinicalTrials.gov, 9 of them currently open to new participants. 2 are in Phase 3-4 (later-stage) and 11 in Phase 1-2 (earlier-stage). The most active sponsor is City of Hope Medical Center, running 2 of these trials.

The research picture

Metastatic Clear Cell Renal Cell Carcinoma has 14 registered US clinical trials, 9 of them open to new participants right now, about 64% of the total.

9
recruiting participants now
64%
of trials open to enrollment
2
in Phase 3–4 (later-stage)
2
top sponsor: City of Hope Medical Center
Phase 18Phase 23Phase 32

Active & Recent Trials

14 total, page 1 of 1

RECRUITING Phase 3 720 participants

Study of Casdatifan and Cabozantinib Versus Placebo and Cabozantinib in Patients With Advanced Clear Cell Renal Cell Carcinoma

Arcus Biosciences

NCT07011719

RECRUITING Phase 3 364 participants

Comparing the Outcome of Immunotherapy-Based Drug Combination Therapy With or Without Surgery to Remove the Kidney in Metastatic Kidney Cancer, the PROBE Trial

SWOG Cancer Research Network

NCT04510597

RECRUITING 324 participants

Immune Checkpoint Inhibitor Response in Solid Tumors Using a Live Tumor Diagnostic Platform

Mayo Clinic

NCT06349642

RECRUITING Phase 1 56 participants

Imaging of Solid Tumors Using 18F-TRX

Rahul Aggarwal

NCT06942104

RECRUITING Phase 1 55 participants

Inulin Gel in Combination With Ipilimumab and Nivolumab for the Treatment of Metastatic or Locally Advanced Kidney Cell Cancer, ICON Trial

University of Michigan Rogel Cancer Center

NCT06866262

RECRUITING Phase 2 54 participants

Genetic Testing to Select Therapy for the Treatment of Advanced or Metastatic Kidney Cancer, OPTIC RCC Study

Vanderbilt-Ingram Cancer Center

NCT05361720

RECRUITING Phase 1 33 participants

Immunotherapy (Nivolumab and Ipilimumab) With and Without a Live Biotherapeutic Product (EXL01) for the Treatment of Metastatic Renal Cell Cancer

City of Hope Medical Center

NCT07128680

RECRUITING Phase 1 28 participants

CBM588 Capsules in Combination With Nivolumab and Ipilimumab for the Treatment of Advanced Stage Kidney Cancer

Osel

NCT06399419

RECRUITING Phase 1 12 participants

Effects of Belzutifan on 89Zr-DFO-girentuximab PET Uptake in Patients With Renal Cell Carcinoma (RCC)

NYU Langone Health

NCT07179770

ACTIVE NOT RECRUITING Phase 2 90 participants

Lenvatinib With Everolimus Versus Cabozantinib for Second-Line or Third-Line Treatment of Metastatic Renal Cell Cancer

M.D. Anderson Cancer Center

NCT05012371

ACTIVE NOT RECRUITING Phase 1 65 participants

DS3201 and Ipilimumab for the Treatment of Metastatic Prostate, Urothelial and Renal Cell Cancers

M.D. Anderson Cancer Center

NCT04388852

ACTIVE NOT RECRUITING Phase 1 31 participants

CBM588 in Combination With Nivolumab and Cabozantinib for the Treatment of Advanced or Metastatic Kidney Cancer

City of Hope Medical Center

NCT05122546

COMPLETED Phase 2 121 participants

A Study of INCMGA00012 in Participants With Selected Solid Tumors (POD1UM-203)

Incyte Corporation

NCT03679767

COMPLETED Phase 1 40 participants

Autophagy Inhibition to Augment Mammilian Target of Rapamycin (mTOR) Inhibition: A Phase I/II Trial of RAD001 and Hydroxychloroquine (HCQ) in Patients With Previously Treated Renal Cell Carcinoma

Abramson Cancer Center at Penn Medicine

NCT01510119

Phase Distribution

PhaseTrial count
Phase 1 8
Phase 2 3
Phase 3 2

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Metastatic Clear Cell Renal Cell Carcinoma Trial Landscape

14 indexed Metastatic Clear Cell Renal Cell Carcinoma studies · 9 recruiting (64%).

Phase mix: 2 late (III/IV) vs 11 early (I/II).

Top sponsor: City of Hope Medical Center (2 trials), 9 others listed. 14 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Metastatic Clear Cell Renal Cell Carcinoma?

PlainTrial tracks 14 US clinical trials for Metastatic Clear Cell Renal Cell Carcinoma, of which 9 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Metastatic Clear Cell Renal Cell Carcinoma?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.