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RECRUITING Phase 3

Study of Casdatifan and Cabozantinib Versus Placebo and Cabozantinib in Patients With Advanced Clear Cell Renal Cell Carcinoma

NCT07011719 · View on ClinicalTrials.gov ↗

Study Summary

The purpose of the study is to evaluate the progression-free survival (PFS) of casdatifan versus placebo when each is given in combination with cabozantinib in adult patients with confirmed advanced or metastatic clear cell Renal Cell Carcinoma who have experienced progression on or after prior anti-PD-1 or anti-PD-L1 immunotherapy.

Interventions

  • DRUG Placebo
  • DRUG Cabozantinib
  • DRUG Casdatifan

Study Locations (20)

California

  • City Of Hope National Medical Center — Duarte
  • University of California San Diego Moores Cancer Center — La Jolla
  • UCLA Hematology Oncology - 100 Med Plaza — Los Angeles
  • University of California San Diego Moores Cancer Center — San Diego

Georgia

  • Piedmont Cancer Institute OneOncology — Atlanta
  • Emory University - Atlanta — Atlanta
  • City of Hope Cancer Center Atlanta — Newnan

Massachusetts

  • Massachusetts General Hospital — Boston
  • Dana-Farber Cancer Institute — Boston

Ohio

  • Cleveland Clinic Foundation — Cleveland
  • University Hospitals Cleveland Medical Center — Cleveland

Arizona

  • City of Hope - Phoenix Cancer Center — Goodyear

Connecticut

  • Yale University — New Haven

Illinois

  • City of Hope - Chicago Cancer Center — Zion

Indiana

  • Indiana University Melvin and Bren Simon Cancer Center — Indianapolis

Trial Details

FieldValue
Enrollment Target 720 participants
Start Date 2025-09-08
Est. Completion 2030-12
Phase Phase 3

Sponsor

Arcus Biosciences

14 total trials

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Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT07011719

The ClinicalTrials.gov registry entry for NCT07011719 describes a study currently listed as recruiting. It is categorized as Phase 3, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 720 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Arcus Biosciences, which has 14 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.

The record links to 2 conditions, with Metastatic Clear Cell Renal Cell Carcinoma appearing as the primary indexed condition, and to 3 interventions — of which Placebo is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.

Geographic footprint matters for practical reasons: NCT07011719 reports 20 study locations spanning 13 distinct geographic areas — top geographies include California, Georgia, Massachusetts. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.

Frequently Asked Questions

What is clinical trial NCT07011719 about?

NCT07011719 is a clinical study titled "Study of Casdatifan and Cabozantinib Versus Placebo and Cabozantinib in Patients With Advanced Clear Cell Renal Cell Carcinoma". The purpose of the study is to evaluate the progression-free survival (PFS) of casdatifan versus placebo when each is given in combination with cabozantinib in adult patients with confirmed advanced or metastatic clear cell Renal Cell Carcinoma who have experienced progression on or after prior anti...

What is the current status of trial NCT07011719?

This trial is currently recruiting. It is a Phase 3 study. The enrollment target is 720 participants. The study started on 2025-09-08. Estimated completion is 2030-12.

What conditions does trial NCT07011719 study?

This clinical trial studies the following conditions: Metastatic Clear Cell Renal Cell Carcinoma, Advanced Clear Cell Renal Cell Carcinoma. These conditions were identified from the trial registry and reflect the primary focus areas of the research.

What interventions are being tested in trial NCT07011719?

The interventions under investigation include: Placebo (DRUG), Cabozantinib (DRUG), Casdatifan (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.

Who is sponsoring clinical trial NCT07011719?

This trial is sponsored by Arcus Biosciences, which has 14 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.

Where is trial NCT07011719 being conducted?

This trial has 20 study locations across Arizona, California, Connecticut, Georgia, Illinois. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial