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ClinicalTrials.gov 12 recruiting now official registry

Melanoma Stage IV clinical trials

12 of 18 indexed Melanoma Stage IV trials are currently recruiting.

18 US clinical trials · 12 currently recruiting

Melanoma Stage IV is the subject of 18 registered US clinical trials on ClinicalTrials.gov, 12 of them currently open to new participants. 0 are in Phase 3-4 (later-stage) and 15 in Phase 1-2 (earlier-stage). The most active sponsor is H. Lee Moffitt Cancer Center and Research Institute, running 3 of these trials.

The research picture

Melanoma Stage IV has 18 registered US clinical trials, 12 of them open to new participants right now, about 67% of the total.

12
recruiting participants now
67%
of trials open to enrollment
0
in Phase 3–4 (later-stage)
3
top sponsor: H. Lee Moffitt Cancer Center and Research Institute
Phase 17Phase 28

Active & Recent Trials

18 total, page 1 of 1

RECRUITING Phase 1 300 participants

MC1R-targeted Alpha-particle Monotherapy and Combination Therapy Trial With Nivolumab in Adults With Advanced Melanoma

Perspective Therapeutics

NCT05655312

RECRUITING Phase 1 240 participants

A Study Assessing KB707 for the Treatment of Locally Advanced or Metastatic Solid Tumors

Krystal Biotech

NCT05970497

RECRUITING Phase 2 162 participants

Study of the Efficacy of Intratumoral L19IL2 or L19TNF or L19IL2/L19TNF, in Combination with Pembrolizumab, in Unresectable Melanoma Patients

Philogen S.p.A.

NCT06284590

RECRUITING Phase 1 117 participants

Safety and Tolerability Study of GIM-531 in Advanced Solid Tumors

Georgiamune

NCT06425926

RECRUITING Phase 2 90 participants

Neoadjuvant and Adjuvant Anti-PD1 or Combinations for Locoregionally Advanced Melanoma

H. Lee Moffitt Cancer Center and Research Institute

NCT06295159

RECRUITING Phase 1 60 participants

A Study of VET3-TGI in Patients With Solid Tumors

KaliVir Immunotherapeutics

NCT06444815

RECRUITING Early Phase 1 50 participants

Adjuvant Therapy Based on Pathologic Response After Neoadjuvant Encorafenib Binimetinib in Melanoma

H. Lee Moffitt Cancer Center and Research Institute

NCT04741997

RECRUITING NA 30 participants

Beta Glucan's Effect on Pembrolizumab Immunologic Response in Stage III-IV Melanoma

Kelly McMasters

NCT04513028

RECRUITING Phase 2 29 participants

IL2 With Ipilimumab Followed by Nivolumab in Stage 3 or 4 Melanoma Patients

H. Lee Moffitt Cancer Center and Research Institute

NCT04562129

RECRUITING Phase 2 25 participants

Binimetinib and Imatinib for Unresectable Stage III-IV KIT-Mutant Melanoma

University of California, San Francisco

NCT04598009

RECRUITING 24 participants

Correlating Early FDG PET/CT and ctDNA in Immune Checkpoint Inhibitor (ICI)-Treated Melanoma Patients

University of Wisconsin, Madison

NCT06199713

RECRUITING Phase 2 14 participants

Metronomic Cyclophosphamide With Pembrolizumab in Checkpoint Inhibitor Refractory Melanoma

University of California, Irvine

NCT06771544

ACTIVE NOT RECRUITING 126 participants

Immune Related Toxicity and Symptom Burden in Chronic Cancer Survivors With Melanoma Receiving Adjuvant Immunotherapy With Immune Checkpoint Inhibitors

M.D. Anderson Cancer Center

NCT04990726

ACTIVE NOT RECRUITING Phase 1 125 participants

A Phase 1-2 Study of ST101 in Patients With Advanced Solid Tumors

Sapience Therapeutics

NCT04478279

ACTIVE NOT RECRUITING Phase 1 77 participants

SX-682 Treatment in Subjects With Metastatic Melanoma Concurrently Treated With Pembrolizumab

Syntrix Biosystems

NCT03161431

ACTIVE NOT RECRUITING Phase 2 48 participants

Neoadjuvant PD-1 Inhibitor Dostarlimab (TSR-042) vs. Combination of Tim-3 Inhibitor Cobolimab (TSR-022) and PD-1 Inhibitor Dostarlimab (TSR-042) in Melanoma

Diwakar Davar

NCT04139902

ACTIVE NOT RECRUITING Phase 2 42 participants

Infliximab for Treatment of Immune Checkpoint Inhibitor Colitis

Massachusetts General Hospital

NCT04305145

COMPLETED Phase 2 184 participants

A Study to Investigate the Novel Agent BNT111 and Cemiplimab in Combination or as Single Agents in Patients With Advanced Melanoma That Has Not Responded to Other Forms of Treatment

BioNTech SE

NCT04526899

Phase Distribution

PhaseTrial count
Phase 1 7
Phase 2 8

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Melanoma Stage IV Trial Landscape

18 indexed Melanoma Stage IV studies · 12 recruiting (67%).

Phase mix: 0 late (III/IV) vs 15 early (I/II).

Top sponsor: H. Lee Moffitt Cancer Center and Research Institute (3 trials), 9 others listed. 18 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Melanoma Stage IV?

PlainTrial tracks 18 US clinical trials for Melanoma Stage IV, of which 12 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Melanoma Stage IV?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.