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NCT04125914 · ClinicalTrials.gov registry record · NA
Weight Management and Health Behavior Intervention in Lowering Cancer Risk for BRCA Positive and Lynch Syndrome Families
A NA study of Lynch Syndrome and Hereditary Breast Carcinoma, sponsored by M.D. Anderson Cancer Center.
- Active
- Registry status
- NA
- Development phase
- 384
- Enrollment target
- 1
- Study location
NCT04125914: Active NA study of Lynch Syndrome and Hereditary Breast Carcinoma, sponsored by M.D. Anderson Cancer Center.
NCT04125914 is a NA study of Lynch Syndrome and Hereditary Breast Carcinoma that is active but no longer recruiting, run by M.D. Anderson Cancer Center. The registered enrollment target is 384 participants, below the 2,298-participant average among 21 other Lynch Syndrome trials with a reported enrollment target (83% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT04125914, a NA study of Lynch Syndrome and Hereditary Breast Carcinoma, is active but no longer recruiting, sponsored by M.D. Anderson Cancer Center.
- ACTIVE NOT RECRUITING
- Registry status
- NA
- Development phase
- 384 participants
- Enrollment target
- 1
- Study location
Study Summary
This trial studies how well weight management and health behavior intervention works in helping patients with hereditary breast and ovarian cancer and Lynch syndrome mutation carriers lose or maintain a healthy weight and lower their risk for cancer. Lifestyle behaviors such as physical activity, diet, and weight management may play a key role in preventing cancers and improving outcomes even in those with hereditary cancer syndromes.
Primary Outcome
The data from the proposed factorial experiment will be analyzed through analysis of variance (ANOVA) with repeated measures. The outcome variable is the percent weight loss of each participant at 4 months. The fixed covariates include indicator variables for all intervention components. The model includes a random intercept that introduces within-family correlation. The main effect of each intervention component will be tested in an F-test at alpha = 0.0125 level. The pairwise interactions of t
Conditions Studied
Interventions
- OTHER Health Promotion and Education
- BEHAVIORAL Exercise Intervention
- OTHER Internet-Based Intervention
- BEHAVIORAL Behavioral Dietary Intervention
- OTHER E-mail
Study Locations (1)
Texas
- M D Anderson Cancer Center - Houston
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 384 participants |
| Start Date | 2017-01-26 |
| Est. Completion | 2026-04-30 |
| Phase | NA |
What the registry record for NCT04125914 still lists
NCT04125914 is an interventional study that assigns participants to a tested intervention. The registered 384 participants enrollment target is mid-sized for trials with a published cap, below the 2,298-participant average among 21 other Lynch Syndrome trials with a reported enrollment target (83% lower).
The record links to 3 conditions, with Lynch Syndrome appearing as the primary indexed condition, and to 5 interventions - of which Health Promotion and Education is the first listed.
NCT04125914 reports a single indexed study location in Texas.
Frequently Asked Questions
What is clinical trial NCT04125914 about?
NCT04125914 is a clinical study titled "Weight Management and Health Behavior Intervention in Lowering Cancer Risk for BRCA Positive and Lynch Syndrome Families". This trial studies how well weight management and health behavior intervention works in helping patients with hereditary breast and ovarian cancer and Lynch syndrome mutation carriers lose or maintain a healthy weight and lower their risk for cancer. Lifestyle behaviors such as physical activity, di...
What is the current status of trial NCT04125914?
This trial is currently active not recruiting. It is a NA study. The enrollment target is 384 participants. The study started on 2017-01-26. Estimated completion is 2026-04-30.
What conditions does trial NCT04125914 study?
This clinical trial studies the following conditions: Lynch Syndrome, Hereditary Breast Carcinoma, Hereditary Ovarian Carcinoma.
What interventions are being tested in trial NCT04125914?
The interventions under investigation include: Health Promotion and Education (OTHER), Exercise Intervention (BEHAVIORAL), Internet-Based Intervention (OTHER), Behavioral Dietary Intervention (BEHAVIORAL), E-mail (OTHER).
Who is sponsoring clinical trial NCT04125914?
This trial is sponsored by M.D. Anderson Cancer Center, which has 2,692 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT04125914 being conducted?
This trial has 1 study location across Texas. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Lynch Syndrome
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT04125914's enrollment target sits among peer trials
384 10th of 21 higher than 12 of 21 other Lynch Syndrome trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Lynch Syndrome trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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