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ClinicalTrials.gov 10 recruiting now official registry

Locally Advanced Solid Tumor clinical trials

10 of 14 indexed Locally Advanced Solid Tumor trials are currently recruiting.

14 US clinical trials · 10 currently recruiting

Locally Advanced Solid Tumor is the subject of 14 registered US clinical trials on ClinicalTrials.gov, 10 of them currently open to new participants. 0 are in Phase 3-4 (later-stage) and 14 in Phase 1-2 (earlier-stage). The most active sponsor is Nuvalent, running 3 of these trials.

The research picture

Locally Advanced Solid Tumor has 14 registered US clinical trials, 10 of them open to new participants right now, about 71% of the total.

10
recruiting participants now
71%
of trials open to enrollment
0
in Phase 3–4 (later-stage)
3
top sponsor: Nuvalent
Phase 112Phase 22

Active & Recent Trials

14 total, page 1 of 1

RECRUITING Phase 1 840 participants

A Study of Neladalkib (NVL-655) in Patients With Advanced NSCLC and Other Solid Tumors Harboring ALK Rearrangement or Activating ALK Mutation (ALKOVE-1)

Nuvalent

NCT05384626

RECRUITING Phase 1 575 participants

FOG-001 in Locally Advanced or Metastatic Solid Tumors

Parabilis Medicines

NCT05919264

RECRUITING Phase 1 359 participants

A Study of Zidesamtinib (NVL-520) in Patients With Advanced NSCLC and Other Solid Tumors Harboring ROS1 Rearrangement (ARROS-1)

Nuvalent

NCT05118789

RECRUITING Phase 1 225 participants

Safety and Tolerability of TNG462 in Patients With MTAP-deleted Solid Tumors

Tango Therapeutics

NCT05732831

RECRUITING Phase 1 200 participants

A Study of NVL-330 in Patients With Advanced or Metastatic HER2-altered NSCLC (HEROEX-1)

Nuvalent

NCT06521554

RECRUITING Phase 1 114 participants

A Study to Assess the Safety, Tolerability, Pharmacokinetic, Pharmacodynamic, Immunogenicity and Antitumour Activity of IPN60300 in Adults With Locally Advanced or Metastatic Solid Tumours

Ipsen

NCT07213817

RECRUITING Phase 1 90 participants

A Study of NTX-1088, a Monoclonal Antibody Targeting the Poliovirus Receptor (PVR, CD155), as Monotherapy and Combined With Pembrolizumab

Nectin Therapeutics

NCT05378425

RECRUITING Phase 2 37 participants

Lattice Radiotherapy for Dose-Escalated Palliation of Bulky Tumors

University of Cincinnati

NCT06416007

RECRUITING Phase 1 30 participants

ACE2016 in Adult Subjects With Locally Advanced or Metastatic Solid Tumors Expressing Epidermal Growth Factor Receptor (EGFR)

Acepodia Biotech

NCT06415487

RECRUITING Phase 2 25 participants

Topical Tretinoin Prophylaxis for Anti-EGFR Induced Skin Toxicity in Patients With Solid Tumors

University of Utah

NCT06358677

ACTIVE NOT RECRUITING Phase 1 320 participants

A Study to Investigate Safety and Tolerability of TransCon IL-2 β/γ Alone or in Combination With Pembrolizumab and/or TransCon TLR7/8 Agonist or Other Anticancer Therapies in Adult Participants With Locally Advanced or Metastatic Solid Tumor Malignancies

Ascendis Pharma Oncology Division A/S

NCT05081609

ACTIVE NOT RECRUITING Phase 1 192 participants

Safety and Tolerability of TNG908 in Patients With MTAP-deleted Solid Tumors

Tango Therapeutics

NCT05275478

ACTIVE NOT RECRUITING Phase 1 111 participants

A First-in-Human, Phase 1 Study of TST003 in Subjects With Solid Tumors

Suzhou Transcenta Therapeutics Co.

NCT05731271

ACTIVE NOT RECRUITING Phase 1 16 participants

QUILT-3.064: PD-L1 t-haNK In Subjects With Locally Advanced Or Metastatic Solid Cancers

ImmunityBio

NCT04050709

Phase Distribution

PhaseTrial count
Phase 1 12
Phase 2 2

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Locally Advanced Solid Tumor Trial Landscape

14 indexed Locally Advanced Solid Tumor studies · 10 recruiting (71%).

Phase mix: 0 late (III/IV) vs 14 early (I/II).

Top sponsor: Nuvalent (3 trials), 9 others listed. 14 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Locally Advanced Solid Tumor?

PlainTrial tracks 14 US clinical trials for Locally Advanced Solid Tumor, of which 10 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Locally Advanced Solid Tumor?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.