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ClinicalTrials.gov 5 recruiting now official registry

Leukemia, Lymphocytic, Chronic, B-Cell clinical trials

5 of 12 indexed Leukemia, Lymphocytic, Chronic, B-Cell trials are currently recruiting.

12 US clinical trials · 5 currently recruiting

Leukemia, Lymphocytic, Chronic, B-Cell is the subject of 12 registered US clinical trials on ClinicalTrials.gov, 5 of them currently open to new participants. 2 are in Phase 3-4 (later-stage) and 9 in Phase 1-2 (earlier-stage). The most active sponsor is Janssen Research & Development, running 3 of these trials.

The research picture

Leukemia, Lymphocytic, Chronic, B-Cell has 12 registered US clinical trials, 5 of them open to new participants right now, about 42% of the total.

5
recruiting participants now
42%
of trials open to enrollment
2
in Phase 3–4 (later-stage)
3
top sponsor: Janssen Research & Development
Phase 16Phase 23Phase 32

Active & Recent Trials

12 total, page 1 of 1

RECRUITING 3,000 participants

Family Study of Lymphoproliferative Disorders

Mayo Clinic

NCT00626496

RECRUITING Phase 3 735 participants

A Study of Nemtabrutinib Plus Venetoclax vs Venetoclax + Rituximab (VR) in Second-line (2L) + Relapsed/Refractory (R/R) Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma (CLL/SLL) (MK-1026-010/BELLWAVE-010).

Merck Sharp & Dohme

NCT05947851

RECRUITING Phase 1 320 participants

Study Evaluating Safety and Efficacy of JCAR017 in Subjects With Relapsed or Refractory Chronic Lymphocytic Leukemia (CLL) or Small Lymphocytic Lymphoma (SLL)

Juno Therapeutics, a Subsidiary of Celgene

NCT03331198

RECRUITING Phase 2 320 participants

A Study to Customize Ibrutinib Treatment Regimens for Participants With Previously Untreated Chronic Lymphocytic Leukemia

Janssen Research & Development

NCT05963074

RECRUITING Phase 1 132 participants

Anti-CD19 Chimeric Antigen Receptor T-Cell Immunotherapy for Leukemias

National Cancer Institute (NCI)

NCT06364423

ACTIVE NOT RECRUITING Phase 1 316 participants

Study of Oral LOXO-338 in Patients With Advanced Blood Cancers

Eli Lilly and Company

NCT05024045

ACTIVE NOT RECRUITING Phase 3 211 participants

A Study of the Combination of Ibrutinib Plus Venetoclax Versus Chlorambucil Plus Obinutuzumab for the First-line Treatment of Participants With Chronic Lymphocytic Leukemia (CLL)/Small Lymphocytic Lymphoma (SLL)

Janssen Research & Development

NCT03462719

ACTIVE NOT RECRUITING Phase 1 167 participants

A Study of JNJ-80948543, a T-cell Redirecting CD79b x CD20 x CD3 Trispecific Antibody, in Participants With Non-Hodgkin Lymphoma (NHL) and Chronic Lymphocytic Leukemia (CLL)

Janssen Research & Development

NCT05424822

ACTIVE NOT RECRUITING Phase 1 108 participants

A Study to Investigate the Safety, Tolerability, PK, PD, and Efficacy of ONO-7018 in Patients With R/R NHL or CLL

Ono Pharmaceutical Co.

NCT05515406

ACTIVE NOT RECRUITING Phase 2 50 participants

Zanubrutinib and Venetoclax as Initial Therapy for Chronic Lymphocytic Leukemia (CLL) With Response-based Obinutuzumab

Weill Medical College of Cornell University

NCT05650723

COMPLETED Phase 2 24 participants

Study to Evaluate Safety and Preliminary Efficacy of Tafasitamab With Idelalisib or Venetoclax in R/R CLL/SLL Patients Pretreated With BTKi

MorphoSys

NCT02639910

COMPLETED Phase 1 20 participants

Safety Study of CC-292 and Lenalidomide in Subjects With Chronic Lymphocytic Leukemia/ Small Lymphocytic Lymphoma

Celgene

NCT01732861

Phase Distribution

PhaseTrial count
Phase 1 6
Phase 2 3
Phase 3 2

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Leukemia, Lymphocytic, Chronic, B-Cell Trial Landscape

12 indexed Leukemia, Lymphocytic, Chronic, B-Cell studies · 5 recruiting (42%).

Phase mix: 2 late (III/IV) vs 9 early (I/II).

Top sponsor: Janssen Research & Development (3 trials), 9 others listed. 12 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Leukemia, Lymphocytic, Chronic, B-Cell?

PlainTrial tracks 12 US clinical trials for Leukemia, Lymphocytic, Chronic, B-Cell, of which 5 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Leukemia, Lymphocytic, Chronic, B-Cell?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.