Medical Information Only. Consult your healthcare provider before considering clinical trial enrollment.
Irritability: full-pipeline trial registry
3 of 4 indexed Irritability trials are currently recruiting.
Corpus placement: #4,115 of 28,707 conditions by registered trial count.
4 US clinical trials · 3 currently recruiting · #4,115 of 28,707 conditions by registered trial count
Irritability: 4 US clinical trials tracked, 3 recruiting.
Irritability is the subject of 4 registered US clinical trials on ClinicalTrials.gov, 3 of them currently open to new participants. 1 are in Phase 3-4 (later-stage) and 1 in Phase 1-2 (earlier-stage). The most active sponsor is National Institute of Mental Health (NIMH), running 2 of these trials.
Enrollment posture brief
Registry condition irritability
OPEN 3 | RECR 75% | LATE 1 | EARLY 1 | RANK #4115 | SPON 2
Volume-matched condition peers
Nearest open-share peer: Activity, Motor (75% recruiting · 8 trials)
Irritability lists 3 open slots (75% of 4 indexed trials). Peers are matched on registered volume, not therapeutic-area browse lists. How peer matching works →
Key findings
What ClinicalTrials.gov does not surface for Irritability on its own pages , computed from the registry mirror as of 2026-08-08. Each line carries its own denominator so it can be quoted as it stands.
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Irritability is recruiting above its size-band peers.
3 of 4 indexed trials (75%) are open to enrollment, against a 46.5% average across 27,806 conditions with fewer than 20 trials. The peer set uses the same ClinicalTrials.gov-derived counts as this page.
Open and recent trials
4 total, page 1 of 1
Psychological Treatments for Youth With Severe Irritability.
National Institute of Mental Health (NIMH)
NCT02531893
Predictors of Improvements in Irritability and Aggression in Children With ADHD Treated With CNS Stimulants
Milton S. Hershey Medical Center
NCT06871488
Study Brain Mechanisms of Frustration With Magnetoencephalography in Healthy Volunteers
National Institute of Mental Health (NIMH)
NCT06484088
Behavior Therapy for Irritability in Autism
Yale University
NCT04654260
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 1 |
| Phase 4 | 1 |
Top Sponsors
Named interventions
Most-linked intervention names on Irritability records (sponsor-reported on ClinicalTrials.gov). Counts are trial links, not unique products.
US sites by state
Facility locations filed on Irritability trials. A trial with sites in several states counts in each.
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Related
What to do with this Irritability page
4 registered trials, 3 currently recruiting, is a starting point for a conversation, not a diagnosis or a recommendation.
- 3 Irritability trials are currently recruiting, check eligibility criteria before contacting a site. Browse recruiting trials
- National Institute of Mental Health (NIMH) sponsors the most Irritability trials on record, review their full trial history before evaluating a specific study. See National Institute of Mental Health (NIMH)'s trials
- Bring the specific trial ID (NCT number) to your own doctor before enrolling, this page is a directory, not medical guidance. Read the trial-finding guide
Trial and recruiting counts reflect ClinicalTrials.gov registry status as of the data vintage above; individual trial eligibility and enrollment status can change.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This Irritability condition card totals 4 registered trials; most-linked intervention Psychoeducation and Supportive Therapy (PST); top US site state Maryland. See our editorial standards & corrections policy, the methodology behind these numbers, the data changelog, or report a data error.