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2026 data Public-data reference. official source

Intrahepatic Cholangiocarcinoma

Open-data reference.

18 US clinical trials · 13 currently recruiting

Active & Recent Trials

RECRUITING 400 participants

An Exosome-Based Liquid Biopsy for the Differential Diagnosis of Primary Liver Cancer

City of Hope Medical Center

NCT06342414

RECRUITING NA 300 participants

Locally ablatIVe thErapy for oLigo-progressive gastrOintestiNal maliGnancies (LIVELONG)

University of California, Davis

NCT06101277

RECRUITING Phase 1 180 participants

A Study to Investigate ALE.P03 as Monotherapy in Adult Patients With Selected Advanced or Metastatic CLDN1+ Solid Tumors

Alentis Therapeutics

NCT07169734

RECRUITING NA 168 participants

Regional or Extend LymphAdenectomy During Resection of Intrahepatic Cholangiocarcinoma

Second Affiliated Hospital, School of Medicine, Zhejiang University

NCT04078230

RECRUITING Phase 2 164 participants

Gemcitabine and Oxaliplatin Chemotherapy With or Without a Floxuridine and Dexamethasone Pump in People With Cholangiocarcinoma That Cannot Be Removed With Surgery

Memorial Sloan Kettering Cancer Center

NCT04891289

RECRUITING Phase 2 97 participants

An Open-Label, Multiple-Center, Phase IIa/IIb Clinical Trial to Evaluate the Efficacy, Safety and Tolerability of VG161 as Monotherapy and in Combination With Nivolumab for Treatment of Patients With Hepatocellular Carcinoma or Intrahepatic Cholangiocarcinoma

Virogin Biotech Canada

NCT05223816

RECRUITING Phase 2 80 participants

Study of Safety/Feasibility of a Hybrid Model of Tertiary and Community Delivery of Hepatic Artery Infusion Chemotherapy

Michael J Cavnar, MD

NCT07201519

RECRUITING Phase 2 62 participants

REGULUS: MRI-guided Adaptive SABR for Liver Cancers

Stanford University

NCT07223307

RECRUITING Phase 1 40 participants

Safety and Anti-Tumor Activity of TYRA-200 in Advanced Cholangiocarcinoma With Activating FGFR2 Gene Alterations

Tyra Biosciences

NCT06160752

RECRUITING Phase 2 38 participants

A Phase II Study of Pemigatinib Plus Durvalumab in Previously Treated Advanced Intrahepatic Cholangiocarcinoma Patients With FGFR-2 Fusion or Rearrangement

Mehmet Akce

NCT06728410

RECRUITING 30 participants

Liver Transplantation in Intrahepatic Cholangiocarcinoma

Rutgers, The State University of New Jersey

NCT06140134

RECRUITING Phase 2 16 participants

The Purpose of This Research Study is to See if Combining Gemcitabine, Cisplatin and Durvalumab Chemotherapy Treatments With a Direct Tumor Therapy Yittrium-90 (Y-90) Will Work Better Together to Shrink Tumors and Control Cancer

Inova Health Care Services

NCT05422690

RECRUITING Phase 1 12 participants

Pressurized Intraperitoneal Aerosolized Nab-Paclitaxel in Combination With Gemcitabine and Cisplatin for the Treatment of Biliary Tract Cancer Patients With Peritoneal Metastases

City of Hope Medical Center

NCT05285358

ACTIVE NOT RECRUITING NA 100 participants

Infusion System for Hepatic Cancer

Ronald DeMatteo, M.D.

NCT04684862

ACTIVE NOT RECRUITING Phase 2 67 participants

A Study of LSTA1 When Added to Standard of Care Versus Standard of Care Alone in Patients With Advanced Solid Tumors

Lisata Therapeutics

NCT05712356

COMPLETED Phase 1 490 participants

REFOCUS: A First-in-Human Study of Highly Selective FGFR2 Inhibitor, RLY-4008, in Patients With ICC and Other Advanced Solid Tumors

Elevar Therapeutics

NCT04526106

COMPLETED Phase 2 55 participants

Hepatic Arterial Infusion (HAI) With Floxuridine (FUDR) and Dexamethasone (Dex) Combined With Systemic Gemcitabine and Oxaliplatin in Patients With Unresectable Intrahepatic Cholangiocarcinoma (ICC)

Memorial Sloan Kettering Cancer Center

NCT01862315

COMPLETED Phase 1 8 participants

Hepatic Arterial Infusion With Floxuridine and Dexamethasone in Combination With Gemcitabine as Adjuvant Treatment After Resection of Intrahepatic Cholangiocarcinoma

Memorial Sloan Kettering Cancer Center

NCT01938729

Phase Distribution

PhaseTrial count
Early Phase 1 5
Phase 2 8

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Intrahepatic Cholangiocarcinoma Trial Landscape

ClinicalTrials.gov lists 18 US studies indexed under Intrahepatic Cholangiocarcinoma, and 13 of those are currently open to recruitment — roughly 72% of the total volume on the registry. That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

The phase distribution for Intrahepatic Cholangiocarcinoma shows 0 late-stage studies (Phase 3 and Phase 4 combined) alongside 13 earlier-phase entries (Phase 1 through Phase 2). Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

Top sponsor activity for Intrahepatic Cholangiocarcinoma is led by Memorial Sloan Kettering Cancer Center with 3 indexed trials, alongside 9 other organizations in the top contributor list. The list on this page surfaces up to 18 of the most relevant recent and active entries, ordered with recruiting studies first so practical options are visible. All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation — eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Intrahepatic Cholangiocarcinoma?

PlainTrial tracks 18 US clinical trials for Intrahepatic Cholangiocarcinoma, of which 13 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Intrahepatic Cholangiocarcinoma?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2024 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

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