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ClinicalTrials.gov 16 recruiting now official registry

HER2-Negative Breast Carcinoma clinical trials

16 of 19 indexed HER2-Negative Breast Carcinoma trials are currently recruiting.

19 US clinical trials · 16 currently recruiting

HER2-Negative Breast Carcinoma is the subject of 19 registered US clinical trials on ClinicalTrials.gov, 16 of them currently open to new participants. 4 are in Phase 3-4 (later-stage) and 9 in Phase 1-2 (earlier-stage). The most active sponsor is Emory University, running 3 of these trials.

The research picture

HER2-Negative Breast Carcinoma has 19 registered US clinical trials, 16 of them open to new participants right now, about 84% of the total.

16
recruiting participants now
84%
of trials open to enrollment
4
in Phase 3–4 (later-stage)
3
top sponsor: Emory University
Phase 15Phase 24Phase 34

Active & Recent Trials

19 total, page 1 of 1

RECRUITING Phase 3 3,680 participants

Adding an Immunotherapy Drug, MEDI4736 (Durvalumab), to the Usual Chemotherapy Treatment (Paclitaxel, Cyclophosphamide, and Doxorubicin) for Stage II-III Breast Cancer

National Cancer Institute (NCI)

NCT06058377

RECRUITING Phase 3 1,000 participants

Palazestrant in Combination With Ribociclib for the First-line Treatment of ER+/HER2- Advanced Breast Cancer

Olema Pharmaceuticals

NCT07085767

RECRUITING Phase 3 510 participants

OP-1250 (Palazestrant) vs. Standard of Care for the Treatment of ER+/HER2- Advanced Breast Cancer

Olema Pharmaceuticals

NCT06016738

RECRUITING NA 410 participants

Mobile Health for Adherence in Breast Cancer Patients

ECOG-ACRIN Cancer Research Group

NCT06112613

RECRUITING Phase 2 176 participants

A Study of the Impact of Endocrine Therapy on Surgical Outcomes in People With Breast Cancer

Memorial Sloan Kettering Cancer Center

NCT07483307

RECRUITING Phase 2 174 participants

Dose-Reduced Docetaxel With Cyclophosphamide for the Treatment of Vulnerable Older Women With Stage I-III HER2 Negative Breast Cancer, the DOROTHY Trial

City of Hope Medical Center

NCT06042569

RECRUITING NA 150 participants

Acutherapy to Prevent Aromatase Inhibitor-Associated Arthralgias in Non-Hispanic Black Postmenopausal Women With Early-Stage Breast Cancer

Emory University

NCT06534125

RECRUITING 100 participants

Prospective Registry of ADC as First- and Second-line Treatment for Breast Cancer

University of California, San Francisco

NCT06774027

RECRUITING Phase 2 58 participants

DATO-BASE: DATOpotamab-deruxtecan for Breast Cancer Brain metAstaSEs

Sarah Sammons, MD

NCT06176261

RECRUITING NA 55 participants

Neoadjuvant Breast Cancer Time Restricted Eating

Thomas Jefferson University

NCT05327608

RECRUITING Phase 1 42 participants

Gemcitabine and Ex Vivo Expanded Allogenic Universal Donor, TGFβi Natural Killer (NK) Cells With or Without Naxitamab (Danyelza) for the Treatment of Patients With Metastatic, GD2 Expressing, HER2 Negative Breast Cancer

Margaret Gatti-Mays

NCT06026657

RECRUITING NA 40 participants

Feasibility Study of Biobehavioral Stress Reduction Intervention in Patients With Triple Negative Breast Cancer

Ohio State University Comprehensive Cancer Center

NCT05677802

RECRUITING Phase 2 40 participants

Turkey Tail Mushroom for Treating Post-Menopausal Women With HER2-Negative ER-Positive Breast Cancer Undergoing Surgery

Mayo Clinic

NCT06450873

RECRUITING Early Phase 1 40 participants

Letrozole With and Without Simvastatin for the Treatment of Stage I-III Hormone Receptor Positive, HER2 Negative Breast Cancer

Emory University

NCT05464810

RECRUITING NA 30 participants

A Feasibility Trial of a Web Based App Intervention in Hormone Positive Breast Cancer Patients to Improve Adherence to Endocrine Therapy

Emory University

NCT05488145

RECRUITING Phase 1 28 participants

A Study of Abemaciclib and Radiation Therapy in People With Metastatic Breast Cancer

Memorial Sloan Kettering Cancer Center

NCT06678269

ACTIVE NOT RECRUITING Phase 3 1,167 participants

Additional Support Program Via Text Messaging and Telephone-Based Counseling for Breast Cancer Patients Receiving Hormonal Therapy

Alliance for Clinical Trials in Oncology

NCT04379570

ACTIVE NOT RECRUITING Phase 1 42 participants

Testing the Addition of an Anti-cancer Drug, Berzosertib, to the Usual Treatment (Radiation Therapy) for Chemotherapy-Resistant Triple-Negative and Estrogen and/or Progesterone Receptor Positive, HER2 Negative Breast Cancer

National Cancer Institute (NCI)

NCT04052555

ACTIVE NOT RECRUITING Phase 1 42 participants

Vaccine Therapy in Treating Patients With HER2-Negative Stage III-IV Breast Cancer

University of Washington

NCT02157051

Phase Distribution

PhaseTrial count
Phase 1 5
Phase 2 4
Phase 3 4

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the HER2-Negative Breast Carcinoma Trial Landscape

19 indexed HER2-Negative Breast Carcinoma studies · 16 recruiting (84%).

Phase mix: 4 late (III/IV) vs 9 early (I/II).

Top sponsor: Emory University (3 trials), 9 others listed. 19 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for HER2-Negative Breast Carcinoma?

PlainTrial tracks 19 US clinical trials for HER2-Negative Breast Carcinoma, of which 16 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for HER2-Negative Breast Carcinoma?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.