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Functional Mitral Regurgitation clinical trials
3 of 6 indexed Functional Mitral Regurgitation trials are currently recruiting.
6 US clinical trials · 3 currently recruiting
Functional Mitral Regurgitation is the subject of 6 registered US clinical trials on ClinicalTrials.gov, 3 of them currently open to new participants. The most active sponsor is Edwards Lifesciences, running 1 of these trials.
The research picture
Functional Mitral Regurgitation has 6 registered US clinical trials, 3 of them open to new participants right now, about 50% of the total.
- 3
- recruiting participants now
- 50%
- of trials open to enrollment
- 0
- in Phase 3–4 (later-stage)
- 1
- top sponsor: Edwards Lifesciences
Active & Recent Trials
6 total, page 1 of 1
Phenotypic Classification of FMR With CMR
The Cleveland Clinic
NCT05965258
The EMPOWER Trial - The Carillon Mitral Contour System® in Treating Heart Failure With at Least Mild FMR
Cardiac Dimensions
NCT03142152
Secondary Mitral Regurgitation Treatment With MitraClip and Assessment by Cardiac Magnetic Resonance
Minneapolis Heart Institute Foundation
NCT07131631
Edwards PASCAL CLASP IID/IIF Pivotal Clinical Trial
Edwards Lifesciences
NCT03706833
Clinical Trial to Evaluate the Safety and Effectiveness of Using the Tendyne Transcatheter Mitral Valve System for the Treatment of Symptomatic Mitral Regurgitation
Abbott Medical Devices
NCT03433274
NHLBI DIR Transcatheter Mitral Cerclage Annuloplasty Early Feasibility Study
National Heart, Lung, and Blood Institute (NHLBI)
NCT03929913
Phase Distribution
Phase data not available
Top Sponsors
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Reading the Functional Mitral Regurgitation Trial Landscape
6 indexed Functional Mitral Regurgitation studies · 3 recruiting (50%).
Phase mix: 0 late (III/IV) vs 0 early (I/II).
Top sponsor: Edwards Lifesciences (1 trial), 5 others listed. 6 shown below, recruiting first.
How to read this condition's trial landscape
That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.
Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.
All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.
Frequently Asked Questions
How many clinical trials are there for Functional Mitral Regurgitation?
PlainTrial tracks 6 US clinical trials for Functional Mitral Regurgitation, of which 3 are currently recruiting participants. Data sourced from ClinicalTrials.gov.
How do I find a recruiting trial for Functional Mitral Regurgitation?
Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.
Is this data current?
Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.
Related
Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.
Read our methodology - how this data is sourced, computed, and verified.
Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.