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ClinicalTrials.gov 8 recruiting now official registry

Ductal Carcinoma In Situ clinical trials

8 of 16 indexed Ductal Carcinoma In Situ trials are currently recruiting.

16 US clinical trials · 8 currently recruiting

Ductal Carcinoma In Situ is the subject of 16 registered US clinical trials on ClinicalTrials.gov, 8 of them currently open to new participants. 1 are in Phase 3-4 (later-stage) and 4 in Phase 1-2 (earlier-stage). The most active sponsor is Xoft, running 2 of these trials.

The research picture

Ductal Carcinoma In Situ has 16 registered US clinical trials, 8 of them open to new participants right now, about 50% of the total.

8
recruiting participants now
50%
of trials open to enrollment
1
in Phase 3–4 (later-stage)
2
top sponsor: Xoft
Phase 11Phase 23Phase 41

Active & Recent Trials

16 total, page 1 of 1

RECRUITING Phase 2 400 participants

DCIS: RECAST Trial Ductal Carcinoma In Situ: Re-Evaluating Conditions for Active Surveillance Suitability as Treatment

QuantumLeap Healthcare Collaborative

NCT06075953

RECRUITING 200 participants

EXploring Inflammation and Social deTerminants Study in Breast Cancer Patients

Thomas Jefferson University

NCT07478016

RECRUITING 200 participants

Accelerated Partial Breast Irradiation (APBI) Using Stereotactic Body Radiation Therapy (SBRT)

RPCR

NCT04985032

RECRUITING Phase 2 90 participants

Ultra Hypo-fractionated Adjuvant Whole Breast Radiation Therapy With Simultaneous Integrated Boost for Early-Stage Breast Cancer (H-ASSIST)

UNC Lineberger Comprehensive Cancer Center

NCT06902311

RECRUITING NA 50 participants

Novel Cavity Marking Technique in Breast Cancer Patients Undergoing Breast Conservation Surgery With Oncoplastic Reconstruction for the Delivery of Adjuvant Radiotherapy and Accuracy of Recommended Re-excisions

University of Florida

NCT06903468

RECRUITING Phase 1 50 participants

Prototype DAA/TAA Vaccine Targeting MUC1 for Immune Interception and Prevention in Ductal Carcinoma In Situ

Finn, Olivera, PhD

NCT06218303

RECRUITING NA 30 participants

Cryoablation as a Minimally Invasive Alternative to Surgery for Managing Ductal Carcinoma In Situ

Glendale Adventist Medical Center d/b/a Adventist Health Glendale

NCT05218044

RECRUITING NA 30 participants

A Study of Disappearing Markers for Daily Radiation Treatment Delivery for Breast Cancer Patients.

Barbara Ann Karmanos Cancer Institute

NCT07095114

ACTIVE NOT RECRUITING NA 1,200 participants

Safety and Efficacy Study of the Xoft® Axxent® eBx® IORT System®

Xoft

NCT01644669

ACTIVE NOT RECRUITING NA 997 participants

Comparing an Operation to Monitoring, With or Without Endocrine Therapy (COMET) Trial For Low Risk DCIS

Alliance Foundation Trials

NCT02926911

ACTIVE NOT RECRUITING NA 265 participants

Intraoperative Radiation Therapy (IORT) in DCIS

Columbia University

NCT03216421

ACTIVE NOT RECRUITING Phase 2 100 participants

Ruxolitinib for Premalignant Breast Disease

Julie Nangia

NCT02928978

COMPLETED NA 115 participants

Breast MRI as a Preoperative Tool for DCIS

Memorial Sloan Kettering Cancer Center

NCT00605982

COMPLETED Phase 4 63 participants

Electronic Xoft Intersociety Brachytherapy Trial: Electronic Brachytherapy (EBT) For Treatment of Early Stage Breast Cancer

Xoft

NCT00742222

COMPLETED 51 participants

Digital Breast Tomosynthesis Versus Contrast Enhanced Magnetic Resonance Imaging (MRI) for Breast Cancer Staging

Dartmouth-Hitchcock Medical Center

NCT01060085

COMPLETED NA 17 participants

Living Well After Breast Surgery

University of Texas at Austin

NCT03834532

Phase Distribution

PhaseTrial count
Phase 1 1
Phase 2 3
Phase 4 1

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Ductal Carcinoma In Situ Trial Landscape

16 indexed Ductal Carcinoma In Situ studies · 8 recruiting (50%).

Phase mix: 1 late (III/IV) vs 4 early (I/II).

Top sponsor: Xoft (2 trials), 9 others listed. 16 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Ductal Carcinoma In Situ?

PlainTrial tracks 16 US clinical trials for Ductal Carcinoma In Situ, of which 8 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Ductal Carcinoma In Situ?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.