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ClinicalTrials.gov 1 recruiting now official registry

Dry Eye Syndromes clinical trials

Every US clinical trial registered for Dry Eye Syndromes — phase mix, recruiting status, and the sponsors running them, straight from the NIH ClinicalTrials.gov registry.

19 US clinical trials · 1 currently recruiting

The research picture

Dry Eye Syndromes has 19 registered US clinical trials, 1 of them open to new participants right now — about 5% of the total.

1
recruiting participants now
5%
of trials open to enrollment
5
in Phase 3–4 (later-stage)
3
top sponsor: Allergan

Counts reflect the public ClinicalTrials.gov registry as last mirrored by PlainTrial. Status and phase are reported by each study's sponsor. This is reference information, not medical advice.

Active & Recent Trials

RECRUITING NA 5,000 participants

Clinical Applications of Advanced Ophthalmic Imaging

University of Miami

NCT03135327

ACTIVE NOT RECRUITING NA 130 participants

Efficacy of OmegaBoost to Increase Omega-3 Levels in Healthy Individuals

Western University of Health Sciences

NCT05763940

COMPLETED Phase 3 315 participants

Safety, Efficacy, and Acceptability Study of an Eye Drop Formulation in Subjects With Dry Eye Disease

Allergan

NCT01459588

COMPLETED Phase 2 240 participants

A Clinical Study Evaluating the Safety and Efficacy of SI-614 Ophthalmic Solution in Patients With Dry Eye.

Seikagaku Corporation

NCT02205840

COMPLETED 229 participants

Diagnostic Evaluation of the Tear Film

TearScience

NCT00761917

COMPLETED Phase 2 220 participants

Safety and Efficacy Study of Rebamipide 2% Ophthalmic Suspension in Patients With Dry Eye

Kubota Vision

NCT01027013

COMPLETED Phase 2 207 participants

CyclASol for the Treatment of Moderate to Severe Dry-eye Disease (DED)

Novaliq

NCT02617667

COMPLETED NA 185 participants

Evaluation of Dry Eye Symptoms in CAE With Application of Intranasal Neurostimulation

Allergan

NCT02910713

COMPLETED Phase 2 150 participants

A Clinical Study Evaluating the Safety and Efficacy of SI-614 Ophthalmic Solution in Patients With Dry Eye

Seikagaku Corporation

NCT01558999

COMPLETED 128 participants

TearLab Refractive Surgery Dry Eye Study

TearLab Corporation

NCT01176045

COMPLETED NA 55 participants

TrueTear in Sjogren's Disease Patients

University of Pennsylvania

NCT03719885

COMPLETED Phase 4 51 participants

Evaluation of Maintaining Visual Performance in Participants Who Engage in Electronic Visual Tasking While Using Restasis®

Allergan

NCT02554981

COMPLETED NA 44 participants

Feasibility of IPL for Reducing Dry Eye Symptoms Caused by MGD

Lumenis Be

NCT02621593

COMPLETED Phase 4 30 participants

ACCURATE Study for Subjects With Dry Eyes

The Eye Centers of Racine and Kenosha

NCT04237012

COMPLETED Phase 2 23 participants

Dry Eye Assessment and Management: Feasibility Study

Asbell, Penny, M.D.

NCT01102257

COMPLETED Phase 4 20 participants

Lipiflow Treatment Alone vs. Lipiflow + Dextenza Treatment for Dry Eye Disease

Eye Surgeons of Indiana

NCT04413279

COMPLETED NA 17 participants

Corneal Epithelial Stem Cells and Dry Eye Disease

Sloan W. Rush, MD

NCT03302273

COMPLETED Phase 1 1 participants

Topical Naloxone to Diagnose Ocular Pain

Seema Capoor

NCT04454281

COMPLETED Phase 3

Study of Cyclosporine in the Treatment of Dry Eye Syndrome (ST-603-005)

Sirion Therapeutics

NCT00502073

Phase Distribution

PhaseTrial count
Phase 1 1
Phase 2 5
Phase 3 2
Phase 4 3

Top Sponsors

Allergan 3 trials
TearScience 1 trials
Seema Capoor 1 trials
Novaliq 1 trials
Kubota Vision 1 trials

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Dry Eye Syndromes Trial Landscape

ClinicalTrials.gov lists 19 US studies indexed under Dry Eye Syndromes, and 1 of those are currently open to recruitment — roughly 5% of the total volume on the registry. That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

The phase distribution for Dry Eye Syndromes shows 5 late-stage studies (Phase 3 and Phase 4 combined) alongside 6 earlier-phase entries (Phase 1 through Phase 2). Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

Top sponsor activity for Dry Eye Syndromes is led by Allergan with 3 indexed trials, alongside 9 other organizations in the top contributor list. The list on this page surfaces up to 19 of the most relevant recent and active entries, ordered with recruiting studies first so practical options are visible. All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation — eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Dry Eye Syndromes?

PlainTrial tracks 19 US clinical trials for Dry Eye Syndromes, of which 1 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Dry Eye Syndromes?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Related

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

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