Medical Information Only. Consult your healthcare provider before considering clinical trial enrollment.

ClinicalTrials.gov 1 recruiting now full pipeline small index

Dry Eye Syndromes: full-pipeline trial registry

1 of 19 indexed Dry Eye Syndromes trials are currently recruiting.

Corpus placement: #902 of 28,707 conditions by registered trial count.

19 US clinical trials · 1 currently recruiting · #902 of 28,707 conditions by registered trial count

Dry Eye Syndromes: 19 US clinical trials tracked, 1 recruiting.

Dry Eye Syndromes is the subject of 19 registered US clinical trials on ClinicalTrials.gov, 1 of them currently open to new participants. 5 are in Phase 3-4 (later-stage) and 6 in Phase 1-2 (earlier-stage). The most active sponsor is Allergan, running 3 of these trials.

Enrollment posture brief

Registry condition dry-eye-syndromes

OPEN 1 | RECR 5% | LATE 5 | EARLY 6 | RANK #902 | SPON 3

Nearest open-share peer: Recurrent Breast Cancer (5% recruiting · 20 trials)

Amyotrophic Lateral Sclerosi52.6%Anesthesia, Local42.1%Alcohol Consumption36.8%Attention Deficit Hyperactiv26.3%Dry Eye Syndromes (this)5%
Open-enrollment share among volume-matched conditions near Dry Eye Syndromes

Dry Eye Syndromes lists 1 open slots (5% of 19 indexed trials). Peers are matched on registered volume, not therapeutic-area browse lists. How peer matching works →

Key findings

What ClinicalTrials.gov does not surface for Dry Eye Syndromes on its own pages , computed from the registry mirror as of 2026-08-08. Each line carries its own denominator so it can be quoted as it stands.

  1. Dry Eye Syndromes is recruiting below its size-band peers.

    1 of 19 indexed trials (5.3%) are open to enrollment, against a 46.5% average across 27,806 conditions with fewer than 20 trials. The peer set uses the same ClinicalTrials.gov-derived counts as this page.

  2. One sponsor concentrates Dry Eye Syndromes research.

    Allergan accounts for 3 of 19 trials (15.8%). 16 distinct sponsors appear on at least one study for this condition label.

  3. Typical Dry Eye Syndromes enrolment sits around 130 participants.

    Median target enrolment is 130 among the 18 trials that report a genuine target (sentinel values excluded). 8 of those (44.4%) plan for fewer than 100 participants.

  4. Dry Eye Syndromes research is mostly interventional.

    17 interventional and 2 observational studies make up this index (89.5% interventional). Study type is sponsor-reported on ClinicalTrials.gov.

Phase 11Phase 25Phase 32Phase 43

Open and recent trials

19 total, page 1 of 1

RECRUITING NA 5,000 participants

Clinical Applications of Advanced Ophthalmic Imaging

University of Miami

NCT03135327

ACTIVE NOT RECRUITING NA 130 participants

Efficacy of OmegaBoost to Increase Omega-3 Levels in Healthy Individuals

Western University of Health Sciences

NCT05763940

COMPLETED Phase 3 315 participants

Safety, Efficacy, and Acceptability Study of an Eye Drop Formulation in Subjects With Dry Eye Disease

Allergan

NCT01459588

COMPLETED Phase 2 240 participants

A Clinical Study Evaluating the Safety and Efficacy of SI-614 Ophthalmic Solution in Patients With Dry Eye.

Seikagaku Corporation

NCT02205840

COMPLETED 229 participants

Diagnostic Evaluation of the Tear Film

TearScience

NCT00761917

COMPLETED Phase 2 220 participants

Safety and Efficacy Study of Rebamipide 2% Ophthalmic Suspension in Patients With Dry Eye

Kubota Vision

NCT01027013

COMPLETED Phase 2 207 participants

CyclASol for the Treatment of Moderate to Severe Dry-eye Disease (DED)

Novaliq

NCT02617667

COMPLETED NA 185 participants

Evaluation of Dry Eye Symptoms in CAE With Application of Intranasal Neurostimulation

Allergan

NCT02910713

COMPLETED Phase 2 150 participants

A Clinical Study Evaluating the Safety and Efficacy of SI-614 Ophthalmic Solution in Patients With Dry Eye

Seikagaku Corporation

NCT01558999

COMPLETED 128 participants

TearLab Refractive Surgery Dry Eye Study

TearLab Corporation

NCT01176045

COMPLETED NA 55 participants

TrueTear in Sjogren's Disease Patients

University of Pennsylvania

NCT03719885

COMPLETED Phase 4 51 participants

Evaluation of Maintaining Visual Performance in Participants Who Engage in Electronic Visual Tasking While Using Restasis®

Allergan

NCT02554981

COMPLETED NA 44 participants

Feasibility of IPL for Reducing Dry Eye Symptoms Caused by MGD

Lumenis Be

NCT02621593

COMPLETED Phase 4 30 participants

ACCURATE Study for Subjects With Dry Eyes

The Eye Centers of Racine and Kenosha

NCT04237012

COMPLETED Phase 2 23 participants

Dry Eye Assessment and Management: Feasibility Study

Asbell, Penny, M.D.

NCT01102257

COMPLETED Phase 4 20 participants

Lipiflow Treatment Alone vs. Lipiflow + Dextenza Treatment for Dry Eye Disease

Eye Surgeons of Indiana

NCT04413279

COMPLETED NA 17 participants

Corneal Epithelial Stem Cells and Dry Eye Disease

Sloan W. Rush, MD

NCT03302273

COMPLETED Phase 1 1 participants

Topical Naloxone to Diagnose Ocular Pain

Seema Capoor

NCT04454281

COMPLETED Phase 3

Study of Cyclosporine in the Treatment of Dry Eye Syndrome (ST-603-005)

Sirion Therapeutics

NCT00502073

Phase Distribution

PhaseTrial count
Phase 1 1
Phase 2 5
Phase 3 2
Phase 4 3

Top Sponsors

Allergan 3 trials
TearScience 1 trials
Seema Capoor 1 trials
Novaliq 1 trials
Kubota Vision 1 trials

Named interventions

Most-linked intervention names on Dry Eye Syndromes records (sponsor-reported on ClinicalTrials.gov). Counts are trial links, not unique products.

Vehicle Drug
2 trials
Carboxymethylcellulose Based Lubricant Eye Drops Drug
1 trials
Carboxymethylcellulose Based Preservative-Free Lubricant Eye Drops Drug
1 trials
Carboxymethylcellulose Based Eye Drop Formulation B Drug
1 trials
Carboxymethylcellulose Based Eye Drop Formulation A Drug
1 trials
Tear Film Analyzer Device
1 trials
Omega-3 EFA Supplement Drug
1 trials
Dexamethasone Intracanalicular Insert, 0.4mg with LipiFlow Thermal Pulsation Drug
1 trials

US sites by state

Facility locations filed on Dry Eye Syndromes trials. A trial with sites in several states counts in each.

Massachusetts 5 trials
Kentucky 4 trials
California 4 trials
Texas 3 trials
Tennessee 3 trials
Maine 3 trials
Pennsylvania 2 trials
Illinois 2 trials

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

What to do with this Dry Eye Syndromes page

19 registered trials, 1 currently recruiting, is a starting point for a conversation, not a diagnosis or a recommendation.

  • 1 Dry Eye Syndromes trials are currently recruiting, check eligibility criteria before contacting a site. Browse recruiting trials
  • Allergan sponsors the most Dry Eye Syndromes trials on record, review their full trial history before evaluating a specific study. See Allergan's trials
  • Bring the specific trial ID (NCT number) to your own doctor before enrolling, this page is a directory, not medical guidance. Read the trial-finding guide

Trial and recruiting counts reflect ClinicalTrials.gov registry status as of the data vintage above; individual trial eligibility and enrollment status can change.

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This Dry Eye Syndromes condition card totals 19 registered trials; most-linked intervention Vehicle; top US site state Massachusetts. See our editorial standards & corrections policy, the methodology behind these numbers, the data changelog, or report a data error.