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ClinicalTrials.gov 5 recruiting now official registry

Clostridium Difficile Infection clinical trials

Every US clinical trial registered for Clostridium Difficile Infection — phase mix, recruiting status, and the sponsors running them, straight from the NIH ClinicalTrials.gov registry.

14 US clinical trials · 5 currently recruiting

The research picture

Clostridium Difficile Infection has 14 registered US clinical trials, 5 of them open to new participants right now — about 36% of the total.

5
recruiting participants now
36%
of trials open to enrollment
1
in Phase 3–4 (later-stage)
1
top sponsor: Finch Research and Development

Counts reflect the public ClinicalTrials.gov registry as last mirrored by PlainTrial. Status and phase are reported by each study's sponsor. This is reference information, not medical advice.

Active & Recent Trials

RECRUITING 4,000 participants

Fecal Microbiota Transplant National Registry

American Gastroenterological Association

NCT03325855

RECRUITING NA 500 participants

Outcomes and Data Collection for Fecal Microbiota Transplantation for the Treatment of Recurrent Clostridium Difficile

Krunal Patel

NCT03562741

RECRUITING Phase 2 260 participants

Alanyl-glutamine Supplementation for C. Difficile Treatment (ACT)

University of Virginia

NCT04305769

RECRUITING Phase 2 176 participants

Enteral Vancomycin as Primary Prophylaxis Against Clostridioides Difficile Infection in Critically Ill Patients

Riverside University Health System Medical Center

NCT07221370

RECRUITING NA 100 participants

Fecal Microbiota Transplantation for C Diff Infection

Englewood Hospital and Medical Center

NCT01905709

COMPLETED 148,549 participants

Protocol for Admission Toxigenic C. Difficile Surveillance

Endeavor Health

NCT04014608

COMPLETED NA 2,461 participants

Validation of the GenePOC CDiff Assay for the Detection of the Toxin B Gene From Toxigenic Clostridium Difficile Strains

Meridian Bioscience

NCT02968758

COMPLETED Phase 2 272 participants

Microbiota Restoration Therapy for Recurrent Clostridium Difficile Infection

Rebiotix

NCT02589847

COMPLETED Phase 2 210 participants

Study of CB-183,315 in Participants With Clostridium Difficile Infection

Cubist Pharmaceuticals LLC, a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA)

NCT01085591

COMPLETED Phase 2 132 participants

Open-Label Extension of CP101 Trials Evaluating Oral Full-Spectrum Microbiota™ (CP101) in Subjects With Recurrence of Clostridium Difficile Infection

Finch Research and Development

NCT03497806

COMPLETED Phase 4 104 participants

Oral Vancomycin to Prevent Recurrent C Difficile Infection With Antibiotics

University of Nevada, Reno

NCT03466502

COMPLETED Phase 2 84 participants

Efficacy, Safety and Tolerability of Cadazolid in Subjects With Clostridium Difficile Associated Diarrhea (CDAD)

Actelion

NCT01222702

COMPLETED Phase 1 7 participants

Vancomycin for the Treatment of NAAT(+)/Toxin(-) C. Difficile

Medical College of Wisconsin

NCT03827447

COMPLETED Phase 2 1 participants

The GRAFT Study: Gut RecolonizAtion by Fecal Transplantation

University of Wisconsin, Madison

NCT03621657

Phase Distribution

PhaseTrial count
Phase 1 1
Phase 2 7
Phase 4 1

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Clostridium Difficile Infection Trial Landscape

ClinicalTrials.gov lists 14 US studies indexed under Clostridium Difficile Infection, and 5 of those are currently open to recruitment — roughly 36% of the total volume on the registry. That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

The phase distribution for Clostridium Difficile Infection shows 1 late-stage studies (Phase 3 and Phase 4 combined) alongside 8 earlier-phase entries (Phase 1 through Phase 2). Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

Top sponsor activity for Clostridium Difficile Infection is led by Finch Research and Development with 1 indexed trial, alongside 9 other organizations in the top contributor list. The list on this page surfaces up to 14 of the most relevant recent and active entries, ordered with recruiting studies first so practical options are visible. All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation — eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Clostridium Difficile Infection?

PlainTrial tracks 14 US clinical trials for Clostridium Difficile Infection, of which 5 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Clostridium Difficile Infection?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Related

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

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