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Clostridium Difficile clinical trials
2 of 7 indexed Clostridium Difficile trials are currently recruiting.
7 US clinical trials · 2 currently recruiting
Clostridium Difficile is the subject of 7 registered US clinical trials on ClinicalTrials.gov, 2 of them currently open to new participants. 1 are in Phase 3-4 (later-stage) and 4 in Phase 1-2 (earlier-stage). The most active sponsor is Romark Laboratories L.C., running 1 of these trials.
The research picture
Clostridium Difficile has 7 registered US clinical trials, 2 of them open to new participants right now, about 29% of the total.
- 2
- recruiting participants now
- 29%
- of trials open to enrollment
- 1
- in Phase 3–4 (later-stage)
- 1
- top sponsor: Romark Laboratories L.C.
Active & Recent Trials
7 total, page 1 of 1
Dynamics of Colonization and Infection by Multidrug-Resistant Pathogens in Immunocompromised and Critically Ill Patients
The Methodist Hospital Research Institute
NCT06258551
VE303 for Prevention of Recurrent Clostridioides Difficile Infection
Vedanta Biosciences
NCT06237452
REMBRANDT: REcovery of the MicroBiome fRom Antibiotics for Dental implanTs
University of Pennsylvania
NCT05622721
Dose-Confirmation, Immunogenicity and Safety Study of the Clostridium Difficile Vaccine Candidate VLA84 in Healthy Adults Aged 50 Years and Older. Phase II Study
Valneva Austria
NCT02316470
Study of Nitazoxanide in the Treatment of Clostridium Difficile Colitis
Romark Laboratories L.C.
NCT00417872
SER-109 Versus Placebo to Prevent Recurrent Clostridium Difficile Infection (RCDI)
Seres Therapeutics
NCT02437487
Early FMT for C.Difficile
Emory University
NCT02465463
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 1 |
| Phase 2 | 3 |
| Phase 3 | 1 |
Top Sponsors
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Reading the Clostridium Difficile Trial Landscape
7 indexed Clostridium Difficile studies · 2 recruiting (29%).
Phase mix: 1 late (III/IV) vs 4 early (I/II).
Top sponsor: Romark Laboratories L.C. (1 trial), 6 others listed. 7 shown below, recruiting first.
How to read this condition's trial landscape
That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.
Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.
All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.
Frequently Asked Questions
How many clinical trials are there for Clostridium Difficile?
PlainTrial tracks 7 US clinical trials for Clostridium Difficile, of which 2 are currently recruiting participants. Data sourced from ClinicalTrials.gov.
How do I find a recruiting trial for Clostridium Difficile?
Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.
Is this data current?
Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.
Related
Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.
Read our methodology - how this data is sourced, computed, and verified.
Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.