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ClinicalTrials.gov 5 recruiting now official registry

Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma clinical trials

5 of 8 indexed Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma trials are currently recruiting.

8 US clinical trials · 5 currently recruiting

Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma is the subject of 8 registered US clinical trials on ClinicalTrials.gov, 5 of them currently open to new participants. 0 are in Phase 3-4 (later-stage) and 6 in Phase 1-2 (earlier-stage). The most active sponsor is City of Hope Medical Center, running 2 of these trials.

The research picture

Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma has 8 registered US clinical trials, 5 of them open to new participants right now, about 63% of the total.

5
recruiting participants now
63%
of trials open to enrollment
0
in Phase 3–4 (later-stage)
2
top sponsor: City of Hope Medical Center
Phase 12Phase 24

Active & Recent Trials

8 total, page 1 of 1

RECRUITING NA 70 participants

The Effects of Exercise on Immune Phenotype of Indolent Non-Hodgkin Lymphoma and Chronic Lymphocytic Leukemia Patients

Mayo Clinic

NCT05876923

RECRUITING Phase 2 61 participants

Acalabrutinib for the Treatment of Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma

Seema Bhat

NCT06757647

RECRUITING NA 50 participants

Implanted Loop Recorders for Detection and Management of Arrhythmia With Bruton Tyrosine Kinase Inhibitors

Northwell Health

NCT05643235

RECRUITING Phase 1 37 participants

Zanubrutinib in Combination With Sonrotoclax for the Treatment of Underrepresented Ethnic and Racial Minorities With Relapsed or Refractory B-cell Non-Hodgkin Lymphoma

City of Hope Medical Center

NCT06859008

RECRUITING Phase 2 34 participants

LP-168 and Obinutuzumab for Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma (CLL/SLL) and Variants of This

Zulfa Omer

NCT06978088

ACTIVE NOT RECRUITING Phase 2 60 participants

Zanubrutinib and Rituximab for the Treatment of Previously Untreated Chronic Lymphocytic Leukemia or Small Lymphocytic Lymphoma

M.D. Anderson Cancer Center

NCT04458610

ACTIVE NOT RECRUITING Phase 2 4 participants

Acalabrutinib for the Treatment of Relapsed or Refractory Autoimmune Hemolytic Anemia in Patients With Chronic Lymphocytic Leukemia

City of Hope Medical Center

NCT04657094

COMPLETED Phase 1 45 participants

A Phase I/Ib Safety and Efficacy Study of the PI3K-delta Inhibitor TGR-1202 and Ibrutinib in Patients With CLL or MCL

Dana-Farber Cancer Institute

NCT02268851

Phase Distribution

PhaseTrial count
Phase 1 2
Phase 2 4

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma Trial Landscape

8 indexed Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma studies · 5 recruiting (63%).

Phase mix: 0 late (III/IV) vs 6 early (I/II).

Top sponsor: City of Hope Medical Center (2 trials), 6 others listed. 8 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma?

PlainTrial tracks 8 US clinical trials for Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma, of which 5 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.