Medical Information Only. Consult your healthcare provider before considering clinical trial enrollment.
Chronic Limb-Threatening Ischemia: early-phase trial registry
8 of 10 indexed Chronic Limb-Threatening Ischemia trials are currently recruiting, with more weight in Phase 1-2.
Corpus placement: #1,724 of 28,707 conditions by registered trial count.
10 US clinical trials · 8 currently recruiting · #1,724 of 28,707 conditions by registered trial count
Chronic Limb-Threatening Ischemia: 10 US clinical trials tracked, 8 recruiting.
Chronic Limb-Threatening Ischemia is the subject of 10 registered US clinical trials on ClinicalTrials.gov, 8 of them currently open to new participants. 0 are in Phase 3-4 (later-stage) and 1 in Phase 1-2 (earlier-stage). The most active sponsor is LimFlow, running 2 of these trials.
Enrollment posture brief
Registry condition chronic-limb-threatening-ischemia
OPEN 8 | RECR 80% | LATE 0 | EARLY 1 | RANK #1724 | SPON 2
Volume-matched condition peers
Nearest open-share peer: Ablation (80% recruiting · 5 trials)
Chronic Limb-Threatening Ischemia lists 8 open slots (80% of 10 indexed trials). Peers are matched on registered volume, not therapeutic-area browse lists. How peer matching works →
Key findings
What ClinicalTrials.gov does not surface for Chronic Limb-Threatening Ischemia on its own pages , computed from the registry mirror as of 2026-08-08. Each line carries its own denominator so it can be quoted as it stands.
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Chronic Limb-Threatening Ischemia is recruiting above its size-band peers.
8 of 10 indexed trials (80%) are open to enrollment, against a 46.5% average across 27,806 conditions with fewer than 20 trials. The peer set uses the same ClinicalTrials.gov-derived counts as this page.
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One sponsor concentrates Chronic Limb-Threatening Ischemia research.
LimFlow accounts for 2 of 10 trials (20%). 9 distinct sponsors appear on at least one study for this condition label.
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Typical Chronic Limb-Threatening Ischemia enrolment sits around 192 participants.
Median target enrolment is 192 among the 10 trials that report a genuine target (sentinel values excluded). 4 of those (40%) plan for fewer than 100 participants.
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Chronic Limb-Threatening Ischemia research is mostly interventional.
9 interventional and 1 observational studies make up this index (90% interventional). Study type is sponsor-reported on ClinicalTrials.gov.
Open and recent trials
10 total, page 1 of 1
Peripheral Bypass Trial for Completion Control
Medistim A
NCT06264843
Bioresorbable Sirolimus-Eluting Scaffold Treatment for Below the Knee Disease
R3 Vascular
NCT06071429
AcoArt Litos PCB Below-the-knee Global Trial
Acotec Scientific Co.
NCT06330493
Esprit BTK Post-Approval Study
Abbott Medical Devices
NCT06656364
Radiotracer-Based Perfusion Imaging of Patients With Peripheral Arterial Disease
Nationwide Children's Hospital
NCT03622359
PROMISE III: Percutaneous Deep Vein Arterialization for the Treatment of Late-Stage Chronic Limb-Threatening Ischemia
LimFlow
NCT05313165
The ROAMM-EHR Study
University of Florida
NCT06263322
Transverse Tibial Transport for Chronic Limb-Threatening Ischemia (CLTI)
University Hospitals Cleveland Medical Center
NCT07175129
BGC101 (EnEPC) Autologous Cell Therapy From Patient's Own Blood for Treatment of Critical Limb Ischemia (CLI)
BioGenCell
NCT02805023
PROMISE I Early Feasibility Trial of the LimFlow Stent Graft System
LimFlow
NCT03124875
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 1 |
Top Sponsors
Named interventions
Most-linked intervention names on Chronic Limb-Threatening Ischemia records (sponsor-reported on ClinicalTrials.gov). Counts are trial links, not unique products.
US sites by state
Facility locations filed on Chronic Limb-Threatening Ischemia trials. A trial with sites in several states counts in each.
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Related
What to do with this Chronic Limb-Threatening Ischemia page
10 registered trials, 8 currently recruiting, is a starting point for a conversation, not a diagnosis or a recommendation.
- 8 Chronic Limb-Threatening Ischemia trials are currently recruiting, check eligibility criteria before contacting a site. Browse recruiting trials
- LimFlow sponsors the most Chronic Limb-Threatening Ischemia trials on record, review their full trial history before evaluating a specific study. See LimFlow's trials
- Bring the specific trial ID (NCT number) to your own doctor before enrolling, this page is a directory, not medical guidance. Read the trial-finding guide
Trial and recruiting counts reflect ClinicalTrials.gov registry status as of the data vintage above; individual trial eligibility and enrollment status can change.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This Chronic Limb-Threatening Ischemia condition card totals 10 registered trials; most-linked intervention LimFlow System; top US site state New York. See our editorial standards & corrections policy, the methodology behind these numbers, the data changelog, or report a data error.