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ACTIVE NOT RECRUITING Phase 1

PMN310 in Patients With Early Alzheimer's Disease (PRECISE-AD)

NCT06750432 · View on ClinicalTrials.gov ↗

Study Summary

This Phase 1b study aims to evaluate the safety, tolerability, pharmacokinetics, pharmacodynamics, and preliminary efficacy of multiple IV infusions of PMN310 in patients with early Alzheimer's disease.

Interventions

  • DRUG Placebo
  • DRUG PMN310

Study Locations (20)

Florida

  • JEM Research Institute — Atlantis
  • Quantum Laboratories — Deerfield Beach
  • Brain Matters Research — Delray Beach
  • Finlay Medical Research — Miami
  • Gonzalez MD and Aswad MD Health Services, Optimus U Corp — Miami
  • Renstar Medical Research — Ocala
  • Charter Research — Orlando
  • Alzheimer's Research and Treatment Center — Stuart
  • Charter Research — The Villages
  • Alzheimer's Research and Treatment Center — Wellington
  • Conquest Research, LLC — Winter Park

California

  • Irvine Center for Clinical Research — Irvine
  • Healthy Brain Research — Long Beach

Georgia

  • Columbus Memory Center, LLC — Columbus
  • CenExel iResearch, LLC — Decatur

Massachusetts

  • Headlands Eastern MA LLC — Plymouth

New Jersey

  • Advanced Memory Research Institute of NJ — Toms River

New York

  • Alzheimer's Disease Research Center — Albany

North Carolina

  • Flourish Research — Matthews

Ohio

  • Neuro Behavioral Clinical Research, Inc. — North Canton

Trial Details

FieldValue
Enrollment Target 144 participants
Start Date 2024-12-13
Est. Completion 2026-12
Phase Phase 1

Sponsor

ProMis Neurosciences

1 total trials

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Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT06750432

The ClinicalTrials.gov registry entry for NCT06750432 describes a study currently listed as active not recruiting. It is categorized as Phase 1, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 144 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is ProMis Neurosciences, which has 1 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.

The record links to 1 condition, with Alzheimer Disease, Early Onset appearing as the primary indexed condition, and to 2 interventions — of which Placebo is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.

Geographic footprint matters for practical reasons: NCT06750432 reports 20 study locations spanning 8 distinct geographic areas — top geographies include Florida, California, Georgia. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.

Frequently Asked Questions

What is clinical trial NCT06750432 about?

NCT06750432 is a clinical study titled "PMN310 in Patients With Early Alzheimer's Disease (PRECISE-AD)". This Phase 1b study aims to evaluate the safety, tolerability, pharmacokinetics, pharmacodynamics, and preliminary efficacy of multiple IV infusions of PMN310 in patients with early Alzheimer's disease.

What is the current status of trial NCT06750432?

This trial is currently active not recruiting. It is a Phase 1 study. The enrollment target is 144 participants. The study started on 2024-12-13. Estimated completion is 2026-12.

What conditions does trial NCT06750432 study?

This clinical trial studies the following conditions: Alzheimer Disease, Early Onset. These conditions were identified from the trial registry and reflect the primary focus areas of the research.

What interventions are being tested in trial NCT06750432?

The interventions under investigation include: Placebo (DRUG), PMN310 (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.

Who is sponsoring clinical trial NCT06750432?

This trial is sponsored by ProMis Neurosciences, which has 1 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.

Where is trial NCT06750432 being conducted?

This trial has 20 study locations across California, Florida, Georgia, Massachusetts, New Jersey. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial