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NCT07225764 · ClinicalTrials.gov registry record · Phase 4
CaOx Stone Prevention
A Phase 4 study of Kidney Stones, sponsored by Icahn School of Medicine at Mount Sinai.
- Recruiting
- Registry status
- Phase 4
- Development phase
- 80
- Enrollment target
- 1
- Study location
NCT07225764: Recruiting Phase 4 study of Kidney Stones, sponsored by Icahn School of Medicine at Mount Sinai.
NCT07225764 is a Phase 4 study of Kidney Stones that is actively recruiting participants, run by Icahn School of Medicine at Mount Sinai. The registered enrollment target is 80 participants, below the 290-participant average among 15 other Kidney Stones trials with a reported enrollment target (72% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT07225764, a Phase 4 study of Kidney Stones, is actively recruiting participants, sponsored by Icahn School of Medicine at Mount Sinai.
- RECRUITING
- Registry status
- Phase 4
- Development phase
- 80 participants
- Enrollment target
- 1
- Study location
Study Summary
This single-center randomized controlled trial at Mount Sinai West will enroll 80 patients undergoing percutaneous nephrolithotomy for calcium oxalate stones. Participants will be randomized to receive either empiric therapy or selective therapy guided by 24-hour urine evaluation. The primary outcome is change in calcium oxalate supersaturation at 4 weeks, aiming to determine whether empiric therapy can provide outcomes comparable to selective therapy while simplifying access to prevention.
Primary Outcome
Change in urine calcium oxalate supersaturation from baseline to the final follow-up visit, measured via 24-hour urine collection. This is a marker that can be predictive of stone episodes, as recurrent stones may take years to develop.
Conditions Studied
Interventions
- DRUG Chlorthalidone
- BEHAVIORAL Low oxalate diet
Study Locations (1)
New York
- Mount Sinai West - New York
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 80 participants |
| Start Date | 2025-10-23 |
| Est. Completion | 2027-06-30 |
| Phase | Phase 4 |
What NCT07225764 shows while recruiting
NCT07225764 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 80 participants, a relatively small participant target, below the 290-participant average among 15 other Kidney Stones trials with a reported enrollment target (72% lower).
The record links to 1 condition, with Kidney Stones appearing as the primary indexed condition, and to 2 interventions - of which Chlorthalidone is the first listed.
NCT07225764 reports a single indexed study location in New York.
Frequently Asked Questions
What is clinical trial NCT07225764 about?
NCT07225764 is a clinical study titled "CaOx Stone Prevention". This single-center randomized controlled trial at Mount Sinai West will enroll 80 patients undergoing percutaneous nephrolithotomy for calcium oxalate stones. Participants will be randomized to receive either empiric therapy or selective therapy guided by 24-hour urine evaluation. The primary outcom...
What is the current status of trial NCT07225764?
This trial is currently recruiting. It is a Phase 4 study. The enrollment target is 80 participants. The study started on 2025-10-23. Estimated completion is 2027-06-30.
What conditions does trial NCT07225764 study?
This clinical trial studies the following conditions: Kidney Stones.
What interventions are being tested in trial NCT07225764?
The interventions under investigation include: Chlorthalidone (DRUG), Low oxalate diet (BEHAVIORAL).
Who is sponsoring clinical trial NCT07225764?
This trial is sponsored by Icahn School of Medicine at Mount Sinai, which has 708 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT07225764 being conducted?
This trial has 1 study location across New York. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Kidney Stones
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT07225764's enrollment target sits among peer trials
80 6th of 15 higher than 9 of 15 other Kidney Stones trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Kidney Stones trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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