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RECRUITING Phase 3

Short Course Vaginal Cuff Brachytherapy in Treating Participants With Stage I-II Endometrial Cancer

NCT03422198 · View on ClinicalTrials.gov ↗

Study Summary

This randomized phase III trial studies short course vaginal cuff brachytherapy to see how well it works compared with standard of care vaginal cuff brachytherapy in treating participants with stage I-II endometrial cancer. Short course vaginal cuff brachytherapy, also known as internal radiation therapy, uses (over a shorter period) radioactive material placed directly into or near a tumor in the upper portion of the vagina to kill tumor cells. After completion of cohort 1 (108 participants), the protocol was expended to add a second cohort of 80 additional participants, and re-opened study recruitment.

Interventions

  • RADIATION Vaginal Cuff Brachytherapy
  • RADIATION Short course vaginal cuff brachytherapy

Study Locations (5)

Utah

  • Huntsman Cancer Institute/University of Utah — Salt Lake City
  • Intermountain Medical Center / LDS Hospital — Salt Lake City

California

  • Stanford Cancer Center — Palo Alto

Illinois

  • Loyola University Medical Center — Maywood

Texas

  • MD Anderson — Houston

Trial Details

FieldValue
Enrollment Target 188 participants
Start Date 2018-02-02
Est. Completion 2029-10-31
Phase Phase 3

Sponsor

University of Utah

686 total trials

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Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT03422198

The ClinicalTrials.gov registry entry for NCT03422198 describes a study currently listed as recruiting. It is categorized as Phase 3, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 188 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is University of Utah, which has 686 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.

The record links to 9 conditions, with Endometrial Serous Adenocarcinoma appearing as the primary indexed condition, and to 2 interventions — of which Vaginal Cuff Brachytherapy is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.

Geographic footprint matters for practical reasons: NCT03422198 reports 5 study locations spanning 4 distinct geographic areas — top geographies include Utah, California, Illinois. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.

Frequently Asked Questions

What is clinical trial NCT03422198 about?

NCT03422198 is a clinical study titled "Short Course Vaginal Cuff Brachytherapy in Treating Participants With Stage I-II Endometrial Cancer". This randomized phase III trial studies short course vaginal cuff brachytherapy to see how well it works compared with standard of care vaginal cuff brachytherapy in treating participants with stage I-II endometrial cancer. Short course vaginal cuff brachytherapy, also known as internal radiation th...

What is the current status of trial NCT03422198?

This trial is currently recruiting. It is a Phase 3 study. The enrollment target is 188 participants. The study started on 2018-02-02. Estimated completion is 2029-10-31.

What conditions does trial NCT03422198 study?

This clinical trial studies the following conditions: Endometrial Serous Adenocarcinoma, Endometrial Clear Cell Adenocarcinoma, Endometrial Endometrioid Adenocarcinoma, Stage I Uterine Corpus Cancer, Stage II Uterine Corpus Cancer. These conditions were identified from the trial registry and reflect the primary focus areas of the research.

What interventions are being tested in trial NCT03422198?

The interventions under investigation include: Vaginal Cuff Brachytherapy (RADIATION), Short course vaginal cuff brachytherapy (RADIATION). Each intervention is being evaluated for safety and efficacy as part of this clinical study.

Who is sponsoring clinical trial NCT03422198?

This trial is sponsored by University of Utah, which has 686 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.

Where is trial NCT03422198 being conducted?

This trial has 5 study locations across California, Illinois, Texas, Utah. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial