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NCT06968988 · ClinicalTrials.gov registry record · Phase 1
Zanzalintinib in Combination With Ipilimumab and Nivolumab in Patients With Metastatic Soft Tissue Sarcoma
A Phase 1 study of Metastatic Soft Tissue Sarcoma, sponsored by Washington University School of Medicine.
- Recruiting
- Registry status
- Phase 1
- Development phase
- 18
- Enrollment target
- 1
- Study location
NCT06968988: Recruiting Phase 1 study of Metastatic Soft Tissue Sarcoma, sponsored by Washington University School of Medicine.
NCT06968988 is a Phase 1 study of Metastatic Soft Tissue Sarcoma that is actively recruiting participants, run by Washington University School of Medicine. The registered enrollment target is 18 participants, below the 139-participant average among 12 other Metastatic Soft Tissue Sarcoma trials with a reported enrollment target (87% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT06968988, a Phase 1 study of Metastatic Soft Tissue Sarcoma, is actively recruiting participants, sponsored by Washington University School of Medicine.
- RECRUITING
- Registry status
- Phase 1
- Development phase
- 18 participants
- Enrollment target
- 1
- Study location
Study Summary
The investigators hypothesize that zanzalintinib in combination with ipilimumab and nivolumab will be well tolerated and serve as a potential therapeutic strategy in metastatic soft tissue sarcoma (mSTS) including myxofibrosarcoma, undifferentiated pleomorphic sarcoma, dedifferentiated liposarcoma, cutaneous angiosarcoma, and undifferentiated sarcoma histologies.
Conditions Studied
Interventions
- DRUG Nivolumab
- DRUG Ipilimumab
- DRUG Zanzalintinib
Study Locations (1)
Missouri
- Washington University School of Medicine - St Louis
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 18 participants |
| Start Date | 2026-01-05 |
| Est. Completion | 2031-07-31 |
| Phase | Phase 1 |
What NCT06968988 shows while recruiting
NCT06968988 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 18 participants, a relatively small participant target, below the 139-participant average among 12 other Metastatic Soft Tissue Sarcoma trials with a reported enrollment target (87% lower).
The record links to 1 condition, with Metastatic Soft Tissue Sarcoma appearing as the primary indexed condition, and to 3 interventions - of which Nivolumab is the first listed.
NCT06968988 reports a single indexed study location in Missouri.
Frequently Asked Questions
What is clinical trial NCT06968988 about?
NCT06968988 is a clinical study titled "Zanzalintinib in Combination With Ipilimumab and Nivolumab in Patients With Metastatic Soft Tissue Sarcoma". The investigators hypothesize that zanzalintinib in combination with ipilimumab and nivolumab will be well tolerated and serve as a potential therapeutic strategy in metastatic soft tissue sarcoma (mSTS) including myxofibrosarcoma, undifferentiated pleomorphic sarcoma, dedifferentiated liposarcoma, ...
What is the current status of trial NCT06968988?
This trial is currently recruiting. It is a Phase 1 study. The enrollment target is 18 participants. The study started on 2026-01-05. Estimated completion is 2031-07-31.
What conditions does trial NCT06968988 study?
This clinical trial studies the following conditions: Metastatic Soft Tissue Sarcoma.
What interventions are being tested in trial NCT06968988?
The interventions under investigation include: Nivolumab (DRUG), Ipilimumab (DRUG), Zanzalintinib (DRUG).
Who is sponsoring clinical trial NCT06968988?
This trial is sponsored by Washington University School of Medicine, which has 1,502 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT06968988 being conducted?
This trial has 1 study location across Missouri. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
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Where NCT06968988's enrollment target sits among peer trials
18 13th of 12 the lowest of 12 other Metastatic Soft Tissue Sarcoma trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Metastatic Soft Tissue Sarcoma trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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