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NCT07219550 · ClinicalTrials.gov registry record · Phase 1
A Study of Calderasib (MK-1084) in Participants With Hepatic Impairment and Healthy Volunteers (MK-1084-017)
A Phase 1 study of Healthy and Hepatic Impairment, sponsored by Merck Sharp & Dohme.
- Recruiting
- Registry status
- Phase 1
- Development phase
- 58
- Enrollment target
- 3
- Study locations
NCT07219550 is a Phase 1 study of Healthy and Hepatic Impairment that is actively recruiting participants, run by Merck Sharp & Dohme. The registered enrollment target is 58 participants, below the 647-participant average among 1,090 other Healthy trials with a reported enrollment target (91% lower). The trial reports 3 study locations across 3 states.
The verdict
NCT07219550, a Phase 1 study of Healthy and Hepatic Impairment, is actively recruiting participants, sponsored by Merck Sharp & Dohme.
- RECRUITING
- Registry status
- Phase 1
- Development phase
- 58 participants
- Enrollment target
- 3
- Study locations
Study Summary
The purpose of this study is to learn what happens to calderasib levels in a person's body over time. Researchers will measure what happens to calderasib levels in the body when it is given to participants with hepatic (liver) impairment and healthy participants. Researchers also want to learn about the safety of MK-1084 when it is given to people with hepatic impairment and if people with hepatic impairment can tolerate it.
Conditions Studied
Interventions
- DRUG Calderasib
Study Locations (3)
Arizona
- Arizona Clinical Trials ( Site 0003) - Chandler
Florida
- Orlando Clinical Research Center ( Site 0001) - Orlando
Texas
- The Texas Liver Institute ( Site 0002) - San Antonio
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 58 participants |
| Start Date | 2025-11-05 |
| Est. Completion | 2026-08-14 |
| Phase | Phase 1 |
Interested in This Trial?
Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT07219550
The ClinicalTrials.gov registry entry for NCT07219550 describes a study currently listed as recruiting, categorized as Phase 1. The registered enrollment target is 58 participants, a figure that helps gauge the scale of data the investigators plan to collect, below the 647-participant average among 1,090 other Healthy trials with a reported enrollment target (91% lower). The listed sponsor is Merck Sharp & Dohme, which has 558 total studies on file at ClinicalTrials.gov.
The record links to 2 conditions, with Healthy appearing as the primary indexed condition, and to 1 intervention - of which Calderasib is the first listed.
NCT07219550 reports 3 study locations spanning 3 distinct geographic areas - top geographies include Arizona, Florida, Texas.
Frequently Asked Questions
What is clinical trial NCT07219550 about?
NCT07219550 is a clinical study titled "A Study of Calderasib (MK-1084) in Participants With Hepatic Impairment and Healthy Volunteers (MK-1084-017)". The purpose of this study is to learn what happens to calderasib levels in a person's body over time. Researchers will measure what happens to calderasib levels in the body when it is given to participants with hepatic (liver) impairment and healthy participants. Researchers also want to learn about...
What is the current status of trial NCT07219550?
This trial is currently recruiting. It is a Phase 1 study. The enrollment target is 58 participants. The study started on 2025-11-05. Estimated completion is 2026-08-14.
What conditions does trial NCT07219550 study?
This clinical trial studies the following conditions: Healthy, Hepatic Impairment.
What interventions are being tested in trial NCT07219550?
The interventions under investigation include: Calderasib (DRUG).
Who is sponsoring clinical trial NCT07219550?
This trial is sponsored by Merck Sharp & Dohme, which has 558 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT07219550 being conducted?
This trial has 3 study locations across Arizona, Florida, Texas. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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Read our methodology - how this data is sourced, computed, and verified.
Related
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page mirrors this trial's own ClinicalTrials.gov registry record, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.