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NCT06952634 · ClinicalTrials.gov registry record · Phase 1
An Investigational Study of ESK-001 in Participants With Normal Liver Function and Participants With Mild, Moderate, and Severe Liver Damage
A Phase 1 study of Hepatic Impairment, sponsored by Alumis.
- Recruiting
- Registry status
- Phase 1
- Development phase
- 48
- Enrollment target
- 4
- Study locations
NCT06952634: Recruiting Phase 1 study of Hepatic Impairment, sponsored by Alumis.
NCT06952634 is a Phase 1 study of Hepatic Impairment that is actively recruiting participants, run by Alumis. The registered enrollment target is 48 participants, above the 35-participant average among 48 other Hepatic Impairment trials with a reported enrollment target (37% higher). The trial reports 4 study locations across 3 states. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT06952634, a Phase 1 study of Hepatic Impairment, is actively recruiting participants, sponsored by Alumis.
- RECRUITING
- Registry status
- Phase 1
- Development phase
- 48 participants
- Enrollment target
- 4
- Study locations
Study Summary
This a phase 1, open label, single dose, parallel cohort study to determine the pharmacokinetics (PK) of study drug (ESK-001) in healthy volunteer participants, and participants with mild, moderate, and severe hepatic impairment.
Conditions Studied
Interventions
- DRUG ESK-001
Study Locations (4)
Florida
- Panax Clinical Research - Miami Lakes
- Orlando Clinical Research Center - Orlando
California
- Orange County Research Center - Lake Forest
Tennessee
- Alliance for Multispecialty Research - Knoxville
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 48 participants |
| Start Date | 2025-04-29 |
| Est. Completion | 2025-12 |
| Phase | Phase 1 |
What NCT06952634 shows while recruiting
NCT06952634 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 48 participants, a relatively small participant target, above the 35-participant average among 48 other Hepatic Impairment trials with a reported enrollment target (37% higher).
The record links to 1 condition, with Hepatic Impairment appearing as the primary indexed condition, and to 1 intervention - of which ESK-001 is the first listed.
NCT06952634 reports a single indexed study location in Florida, California, Tennessee.
Frequently Asked Questions
What is clinical trial NCT06952634 about?
NCT06952634 is a clinical study titled "An Investigational Study of ESK-001 in Participants With Normal Liver Function and Participants With Mild, Moderate, and Severe Liver Damage". This a phase 1, open label, single dose, parallel cohort study to determine the pharmacokinetics (PK) of study drug (ESK-001) in healthy volunteer participants, and participants with mild, moderate, and severe hepatic impairment.
What is the current status of trial NCT06952634?
This trial is currently recruiting. It is a Phase 1 study. The enrollment target is 48 participants. The study started on 2025-04-29. Estimated completion is 2025-12.
What conditions does trial NCT06952634 study?
This clinical trial studies the following conditions: Hepatic Impairment.
What interventions are being tested in trial NCT06952634?
The interventions under investigation include: ESK-001 (DRUG).
Who is sponsoring clinical trial NCT06952634?
This trial is sponsored by Alumis, which has 13 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT06952634 being conducted?
This trial has 4 study locations across California, Florida, Tennessee. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Hepatic Impairment
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT06952634's enrollment target sits among peer trials
48 7th of 48 higher than 42 of 48 other Hepatic Impairment trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Hepatic Impairment trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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