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NCT07269301 · ClinicalTrials.gov registry record · Phase 1
A Study to Learn How the Body Processes the Study Medicine PF-07328948 in People With and Without Reduced Liver Function
A Phase 1 study of Healthy and Hepatic Impairment, sponsored by Pfizer.
- Recruiting
- Registry status
- Phase 1
- Development phase
- 26
- Enrollment target
- 3
- Study locations
NCT07269301: Recruiting Phase 1 study of Healthy and Hepatic Impairment, sponsored by Pfizer.
NCT07269301 is a Phase 1 study of Healthy and Hepatic Impairment that is actively recruiting participants, run by Pfizer. The registered enrollment target is 26 participants, below the 647-participant average among 1,090 other Healthy trials with a reported enrollment target (96% lower). The trial reports 3 study locations across 2 states. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT07269301, a Phase 1 study of Healthy and Hepatic Impairment, is actively recruiting participants, sponsored by Pfizer.
- RECRUITING
- Registry status
- Phase 1
- Development phase
- 26 participants
- Enrollment target
- 3
- Study locations
Study Summary
The purpose of this study is to understand the effects of decreased liver function on the study medicine (PF-07328948). People with decreased liver function may process the study medicine differently from healthy people. Study is seeking participants who: * Are between 18 and 75 years of age. * Have a BMI (body mass index) of 17.5 to 40 kg/m2, inclusive, and a total body weight of more than or equal to 45 kilograms or 99 pounds. Participants will take the study medicine as a tablet once at the study clinic and then will stay onsite for about 6 days. During this time, the study team will check for the participant's treatment experience and take some blood samples to test the level of PF-07328948. This will help understand if certain level of decreased liver function could affect the study medicine being processed in the body.
Primary Outcome
Fu is the fraction of unbound drug in plasma, which is calculated by Cu/C (where Cu represents unbound concentration and C represents total concentration).
Conditions Studied
Interventions
- DRUG PF-07328948
Study Locations (3)
Florida
- Orlando Clinical Research Center - Orlando
- Genesis Clinical Research, LLC - Tampa
California
- Orange County Research Center - Lake Forest
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 26 participants |
| Start Date | 2025-12-29 |
| Est. Completion | 2027-02-23 |
| Phase | Phase 1 |
What NCT07269301 shows while recruiting
NCT07269301 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 26 participants, a relatively small participant target, below the 647-participant average among 1,090 other Healthy trials with a reported enrollment target (96% lower).
The record links to 2 conditions, with Healthy appearing as the primary indexed condition, and to 1 intervention - of which PF-07328948 is the first listed.
NCT07269301 reports a single indexed study location in Florida, California.
Frequently Asked Questions
What is clinical trial NCT07269301 about?
NCT07269301 is a clinical study titled "A Study to Learn How the Body Processes the Study Medicine PF-07328948 in People With and Without Reduced Liver Function". The purpose of this study is to understand the effects of decreased liver function on the study medicine (PF-07328948). People with decreased liver function may process the study medicine differently from healthy people. Study is seeking participants who: * Are between 18 and 75 years of age. * Ha...
What is the current status of trial NCT07269301?
This trial is currently recruiting. It is a Phase 1 study. The enrollment target is 26 participants. The study started on 2025-12-29. Estimated completion is 2027-02-23.
What conditions does trial NCT07269301 study?
This clinical trial studies the following conditions: Healthy, Hepatic Impairment.
What interventions are being tested in trial NCT07269301?
The interventions under investigation include: PF-07328948 (DRUG).
Who is sponsoring clinical trial NCT07269301?
This trial is sponsored by Pfizer, which has 1,845 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT07269301 being conducted?
This trial has 3 study locations across California, Florida. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Healthy
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT07269301's enrollment target sits among peer trials
26 760th of 1090 higher than 314 of 1,090 other Healthy trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Healthy trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
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