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NCT06864104 · ClinicalTrials.gov registry record · Phase 2
A Study to Investigate Tonlamarsen for the Treatment of Adults With Uncontrolled Hypertension (KARDINAL)
A Phase 2 study of Hypertension, sponsored by Kardigan.
- Active
- Registry status
- Phase 2
- Development phase
- 206
- Enrollment target
- 20
- Study locations
NCT06864104: Active Phase 2 study of Hypertension, sponsored by Kardigan.
NCT06864104 is a Phase 2 study of Hypertension that is active but no longer recruiting, run by Kardigan. The registered enrollment target is 206 participants, below the 3,507-participant average among 470 other Hypertension trials with a reported enrollment target (94% lower). The trial reports 20 study locations across 8 states. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT06864104, a Phase 2 study of Hypertension, is active but no longer recruiting, sponsored by Kardigan.
- ACTIVE NOT RECRUITING
- Registry status
- Phase 2
- Development phase
- 206 participants
- Enrollment target
- 20
- Study locations
Study Summary
The purpose of this study is to evaluate the blood pressure (BP)-lowering efficacy of tonlamarsen in adult participants who, despite taking 2 or more antihypertensive medications, have not achieved their target blood pressure (BP).
Primary Outcome
Percent Change from baseline (Week 0) in plasma angiotensinogen (AGT) levels to Week 20
Conditions Studied
Interventions
- DRUG Placebo
- DRUG Tonlamarsen
Study Locations (20)
California
- North Coast Cardiology - Encinitas
- Orange County Research Center - Lake Forest
- Clinical Trials Research - Lincoln
- American Institute of Research - Los Angeles
Florida
- Homestead Associates in Research, Inc. - Homestead
- Jacksonville Center for Clinical Research - Jacksonville
- Suncoast Clinical Research, Inc. - New Port Richey
- Progressive Medical Research - Port Orange
Illinois
- Eagle Clinical Research - Chicago
- Clinical Investigation Specialists, Inc. - Gurnee
- Koch Family Medicine Clinical Research - Morton
Alabama
- Pinnacle Research Group - Anniston
- Achieve Clinical Research, LLC - Birmingham
Arizona
- Elite Clinical Studies - Phoenix
- Del Sol Research Management, LLC - Tucson
Georgia
- Agile Clinical Research Trials, LLC - Atlanta
- Velocity Clinical Reseach - Savannah
Louisiana
- Tandem Clinical Research GI, LLC - Marrero
- IMA Clinical Research - Monroe
Arkansas
- Cardiology and Medicine Clinic - Little Rock
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 206 participants |
| Start Date | 2025-04-10 |
| Est. Completion | 2026-03-11 |
| Phase | Phase 2 |
What the registry record for NCT06864104 still lists
NCT06864104 is an interventional study that assigns participants to a tested intervention. The registered 206 participants enrollment target is mid-sized for trials with a published cap, below the 3,507-participant average among 470 other Hypertension trials with a reported enrollment target (94% lower).
The record links to 1 condition, with Hypertension appearing as the primary indexed condition, and to 2 interventions - of which Placebo is the first listed.
NCT06864104 names 20 study sites across 8 states, led by California, Florida, Illinois.
Frequently Asked Questions
What is clinical trial NCT06864104 about?
NCT06864104 is a clinical study titled "A Study to Investigate Tonlamarsen for the Treatment of Adults With Uncontrolled Hypertension (KARDINAL)". The purpose of this study is to evaluate the blood pressure (BP)-lowering efficacy of tonlamarsen in adult participants who, despite taking 2 or more antihypertensive medications, have not achieved their target blood pressure (BP).
What is the current status of trial NCT06864104?
This trial is currently active not recruiting. It is a Phase 2 study. The enrollment target is 206 participants. The study started on 2025-04-10. Estimated completion is 2026-03-11.
What conditions does trial NCT06864104 study?
This clinical trial studies the following conditions: Hypertension.
What interventions are being tested in trial NCT06864104?
The interventions under investigation include: Placebo (DRUG), Tonlamarsen (DRUG).
Who is sponsoring clinical trial NCT06864104?
This trial is sponsored by Kardigan, which has 4 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT06864104 being conducted?
This trial has 20 study locations across Alabama, Arizona, Arkansas, California, Florida. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Hypertension
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT06864104's enrollment target sits among peer trials
206 216th of 470 higher than 255 of 470 other Hypertension trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Hypertension trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
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