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NCT06864104 · ClinicalTrials.gov registry record · Phase 2
A Study to Investigate Tonlamarsen for the Treatment of Adults With Uncontrolled Hypertension (KARDINAL)
A Phase 2 study of Hypertension, sponsored by Kardigan.
- Active
- Registry status
- Phase 2
- Development phase
- 206
- Enrollment target
- 20
- Study locations
NCT06864104 is a Phase 2 study of Hypertension that is active but no longer recruiting, run by Kardigan. The registered enrollment target is 206 participants, below the 3,507-participant average among 470 other Hypertension trials with a reported enrollment target (94% lower). The trial reports 20 study locations across 8 states.
The verdict
NCT06864104, a Phase 2 study of Hypertension, is active but no longer recruiting, sponsored by Kardigan.
- ACTIVE NOT RECRUITING
- Registry status
- Phase 2
- Development phase
- 206 participants
- Enrollment target
- 20
- Study locations
Study Summary
The purpose of this study is to evaluate the blood pressure (BP)-lowering efficacy of tonlamarsen in adult participants who, despite taking 2 or more antihypertensive medications, have not achieved their target blood pressure (BP).
Conditions Studied
Interventions
- DRUG Placebo
- DRUG Tonlamarsen
Study Locations (20)
California
- North Coast Cardiology - Encinitas
- Orange County Research Center - Lake Forest
- Clinical Trials Research - Lincoln
- American Institute of Research - Los Angeles
Florida
- Homestead Associates in Research, Inc. - Homestead
- Jacksonville Center for Clinical Research - Jacksonville
- Suncoast Clinical Research, Inc. - New Port Richey
- Progressive Medical Research - Port Orange
Illinois
- Eagle Clinical Research - Chicago
- Clinical Investigation Specialists, Inc. - Gurnee
- Koch Family Medicine Clinical Research - Morton
Alabama
- Pinnacle Research Group - Anniston
- Achieve Clinical Research, LLC - Birmingham
Arizona
- Elite Clinical Studies - Phoenix
- Del Sol Research Management, LLC - Tucson
Georgia
- Agile Clinical Research Trials, LLC - Atlanta
- Velocity Clinical Reseach - Savannah
Louisiana
- Tandem Clinical Research GI, LLC - Marrero
- IMA Clinical Research - Monroe
Arkansas
- Cardiology and Medicine Clinic - Little Rock
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 206 participants |
| Start Date | 2025-04-10 |
| Est. Completion | 2026-03-11 |
| Phase | Phase 2 |
Interested in This Trial?
Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT06864104
The ClinicalTrials.gov registry entry for NCT06864104 describes a study currently listed as active not recruiting, categorized as Phase 2. The registered enrollment target is 206 participants, a figure that helps gauge the scale of data the investigators plan to collect, below the 3,507-participant average among 470 other Hypertension trials with a reported enrollment target (94% lower). The listed sponsor is Kardigan, which has 4 total studies on file at ClinicalTrials.gov.
The record links to 1 condition, with Hypertension appearing as the primary indexed condition, and to 2 interventions - of which Placebo is the first listed.
NCT06864104 reports 20 study locations spanning 8 distinct geographic areas - top geographies include California, Florida, Illinois.
Frequently Asked Questions
What is clinical trial NCT06864104 about?
NCT06864104 is a clinical study titled "A Study to Investigate Tonlamarsen for the Treatment of Adults With Uncontrolled Hypertension (KARDINAL)". The purpose of this study is to evaluate the blood pressure (BP)-lowering efficacy of tonlamarsen in adult participants who, despite taking 2 or more antihypertensive medications, have not achieved their target blood pressure (BP).
What is the current status of trial NCT06864104?
This trial is currently active not recruiting. It is a Phase 2 study. The enrollment target is 206 participants. The study started on 2025-04-10. Estimated completion is 2026-03-11.
What conditions does trial NCT06864104 study?
This clinical trial studies the following conditions: Hypertension.
What interventions are being tested in trial NCT06864104?
The interventions under investigation include: Placebo (DRUG), Tonlamarsen (DRUG).
Who is sponsoring clinical trial NCT06864104?
This trial is sponsored by Kardigan, which has 4 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT06864104 being conducted?
This trial has 20 study locations across Alabama, Arizona, Arkansas, California, Florida. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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Read our methodology - how this data is sourced, computed, and verified.
Related
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page mirrors this trial's own ClinicalTrials.gov registry record, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.