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COMPLETED Phase 2

Study of a JAK3 Inhibitor for the Prevention of Acute Rejection in Kidney Transplant Patients

NCT00483756 · View on ClinicalTrials.gov ↗

Study Summary

A new immunosuppressive drug, based on the inhibition of an important enzyme in the immune system called JAK3, is being developed by Pfizer to prevent transplant rejection. In this research study, a JAK3 inhibitor or cyclosporine will be given to new kidney transplant patients for 12 months. Patients will be assigned to one of three treatment groups after receiving a kidney transplant. Two of the treatment groups will receive 2 different dosing regimens of the JAK3 inhibitor that will be taken by mouth. The third treatment group will be a standard-of-care control arm. Patients will continue to take the assigned study medication for 12 months as well as other standard transplant medications such as prednisone.

Conditions Studied

Interventions

  • DRUG Cyclosporine
  • DRUG CP-690,550

Study Locations (20)

California

  • Pfizer Investigational Site — Los Angeles
  • Pfizer Investigational Site — Los Angeles
  • Pfizer Investigational Site — Palo Alto
  • Pfizer Investigational Site — San Diego
  • Pfizer Investigational Site — San Francisco
  • Pfizer Investigational Site — San Francisco
  • Pfizer Investigational Site — Stanford

Florida

  • Pfizer Investigational Site — Gainesville
  • Pfizer Investigational Site — Gainsville
  • Pfizer Investigational Site — Tampa

Massachusetts

  • Pfizer Investigational Site — Boston
  • Pfizer Investigational Site — Springfield
  • Pfizer Investigational Site — Springfield

Connecticut

  • Pfizer Investigational Site — New Haven
  • Pfizer Investigational Site — New Haven

Illinois

  • Pfizer Investigational Site — Chicago
  • Pfizer Investigational Site — Chicago

Arkansas

  • Pfizer Investigational Site — Little Rock

Colorado

  • Pfizer Investigational Site — Aurora

Maryland

  • Pfizer Investigational Site — Baltimore

Trial Details

FieldValue
Enrollment Target 338 participants
Start Date 2007-08
Est. Completion 2010-04
Phase Phase 2

Sponsor

Pfizer

769 total trials

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Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT00483756

The ClinicalTrials.gov registry entry for NCT00483756 describes a study currently listed as completed. It is categorized as Phase 2, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 338 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Pfizer, which has 769 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.

The record links to 1 condition, with Kidney Transplantation appearing as the primary indexed condition, and to 2 interventions — of which Cyclosporine is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.

Geographic footprint matters for practical reasons: NCT00483756 reports 20 study locations spanning 8 distinct geographic areas — top geographies include California, Florida, Massachusetts. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.

Frequently Asked Questions

What is clinical trial NCT00483756 about?

NCT00483756 is a clinical study titled "Study of a JAK3 Inhibitor for the Prevention of Acute Rejection in Kidney Transplant Patients". A new immunosuppressive drug, based on the inhibition of an important enzyme in the immune system called JAK3, is being developed by Pfizer to prevent transplant rejection. In this research study, a JAK3 inhibitor or cyclosporine will be given to new kidney transplant patients for 12 months. Patient...

What is the current status of trial NCT00483756?

This trial is currently completed. It is a Phase 2 study. The enrollment target is 338 participants. The study started on 2007-08. Estimated completion is 2010-04.

What conditions does trial NCT00483756 study?

This clinical trial studies the following conditions: Kidney Transplantation. These conditions were identified from the trial registry and reflect the primary focus areas of the research.

What interventions are being tested in trial NCT00483756?

The interventions under investigation include: Cyclosporine (DRUG), CP-690,550 (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.

Who is sponsoring clinical trial NCT00483756?

This trial is sponsored by Pfizer, which has 769 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.

Where is trial NCT00483756 being conducted?

This trial has 20 study locations across Arkansas, California, Colorado, Connecticut, Florida. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial