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NCT06542250 · ClinicalTrials.gov registry record · Phase 1
A Study to Evaluate Safety, PK, PD and Efficacy of AZD5492, a T Cell-engaging Antibody Targeting CD20 in Subjects With R/R B-Cell Malignancies.
A Phase 1 study of B-cell Malignancies, sponsored by AstraZeneca.
- Recruiting
- Registry status
- Phase 1
- Development phase
- 174
- Enrollment target
- 20
- Study locations
NCT06542250: Recruiting Phase 1 study of B-cell Malignancies, sponsored by AstraZeneca.
NCT06542250 is a Phase 1 study of B-cell Malignancies that is actively recruiting participants, run by AstraZeneca. The registered enrollment target is 174 participants, below the 305-participant average among 6 other B-cell Malignancies trials with a reported enrollment target (43% lower). The trial reports 20 study locations across 11 states. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT06542250, a Phase 1 study of B-cell Malignancies, is actively recruiting participants, sponsored by AstraZeneca.
- RECRUITING
- Registry status
- Phase 1
- Development phase
- 174 participants
- Enrollment target
- 20
- Study locations
Study Summary
This is a Phase I/II study designed to evaluate if experimental T cell engaging antibody targeting CD20 AZD5492 is safe, tolerable and efficacious in participants with Relapsed or Refractory B-Cell Malignancies.
Primary Outcome
DLTs are dose-limiting toxicities as defined in the study protocol.
Conditions Studied
Interventions
- DRUG AZD5492
Study Locations (20)
Other
- Research Site - Melbourne
- Research Site - Nedlands
- Research Site - Hangzhou
- Research Site - Shanghai
- Research Site - København Ø
- Research Site - Pessac
- Research Site - Villejuif
- Research Site - München
New York
- Research Site - New York
- Research Site - New York
North Carolina
- Research Site - Charlotte
- Research Site - Winston-Salem
California
- Research Site - La Jolla
Massachusetts
- Research Site - Boston
New Jersey
- Research Site - Hackensack
Texas
- Research Site - Houston
Washington
- Research Site - Seattle
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 174 participants |
| Start Date | 2024-09-18 |
| Est. Completion | 2028-02-14 |
| Phase | Phase 1 |
What NCT06542250 shows while recruiting
NCT06542250 is an interventional study that assigns participants to a tested intervention. The registered 174 participants enrollment target is mid-sized for trials with a published cap, below the 305-participant average among 6 other B-cell Malignancies trials with a reported enrollment target (43% lower).
The record links to 1 condition, with B-cell Malignancies appearing as the primary indexed condition, and to 1 intervention - of which AZD5492 is the first listed.
NCT06542250 names 20 study sites across 11 states, led by Other, New York, North Carolina.
Frequently Asked Questions
What is clinical trial NCT06542250 about?
NCT06542250 is a clinical study titled "A Study to Evaluate Safety, PK, PD and Efficacy of AZD5492, a T Cell-engaging Antibody Targeting CD20 in Subjects With R/R B-Cell Malignancies.". This is a Phase I/II study designed to evaluate if experimental T cell engaging antibody targeting CD20 AZD5492 is safe, tolerable and efficacious in participants with Relapsed or Refractory B-Cell Malignancies.
What is the current status of trial NCT06542250?
This trial is currently recruiting. It is a Phase 1 study. The enrollment target is 174 participants. The study started on 2024-09-18. Estimated completion is 2028-02-14.
What conditions does trial NCT06542250 study?
This clinical trial studies the following conditions: B-cell Malignancies.
What interventions are being tested in trial NCT06542250?
The interventions under investigation include: AZD5492 (DRUG).
Who is sponsoring clinical trial NCT06542250?
This trial is sponsored by AstraZeneca, which has 1,285 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT06542250 being conducted?
This trial has 20 study locations across California, Massachusetts, New Jersey, New York, North Carolina. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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