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ACTIVE NOT RECRUITING Phase 2

Rollover Study to Provide Continued Treatment for Participants With B-Cell Malignancies Previously Enrolled in Studies of Parsaclisib (INCB050465)

NCT04509700 · View on ClinicalTrials.gov ↗

Study Summary

This is a Phase 2, multicenter, open-label study to provide continued supply of parsaclisib as monotherapy or in combination therapy with itacitinib, ruxolitinib, or ibrutinib to participants from Incyte-sponsored studies of parsaclisib.

Conditions Studied

Interventions

  • DRUG Parsaclisib
  • DRUG parsaclisib + itacitinib
  • DRUG parsaclisib + ruxolitinib
  • DRUG parsaclisib + ibrutinib

Study Locations (20)

California

  • City of Hope National Medical Center — Duarte
  • California Cancer Associates For Research and Excellence — Fresno
  • Innovative Clinical Research Institute — Long Beach

Alabama

  • Uab Comprehensive Cancer Center — Birmingham
  • University of Alabama At Birmingham — Birmingham

Arizona

  • Mayo Clinic Rochester — Phoenix
  • University of Arizona Cancer Center-Out Pt. — Tucson

Missouri

  • Saint Luke'S Hospital of Kansas City — Kansas City
  • Hca Midwest Health-Research Medical Center — Kansas City

New York

  • Roswell Park Cancer Institute — Buffalo
  • Memorial Sloan Kettering Cancer Center — New York

Colorado

  • Rocky Mountain Cancer Center — Aurora

Illinois

  • Rush University Medical Center-Consultants in Hematology — Chicago

Kansas

  • University of Kansas Hospital Authority — Westwood

Trial Details

FieldValue
Enrollment Target 112 participants
Start Date 2020-08-03
Est. Completion 2027-09-30
Phase Phase 2

Sponsor

Incyte Corporation

163 total trials

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Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT04509700

The ClinicalTrials.gov registry entry for NCT04509700 describes a study currently listed as active not recruiting. It is categorized as Phase 2, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 112 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Incyte Corporation, which has 163 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.

The record links to 1 condition, with B-Cell Malignancies appearing as the primary indexed condition, and to 4 interventions — of which Parsaclisib is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.

Geographic footprint matters for practical reasons: NCT04509700 reports 20 study locations spanning 14 distinct geographic areas — top geographies include California, Alabama, Arizona. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.

Frequently Asked Questions

What is clinical trial NCT04509700 about?

NCT04509700 is a clinical study titled "Rollover Study to Provide Continued Treatment for Participants With B-Cell Malignancies Previously Enrolled in Studies of Parsaclisib (INCB050465)". This is a Phase 2, multicenter, open-label study to provide continued supply of parsaclisib as monotherapy or in combination therapy with itacitinib, ruxolitinib, or ibrutinib to participants from Incyte-sponsored studies of parsaclisib.

What is the current status of trial NCT04509700?

This trial is currently active not recruiting. It is a Phase 2 study. The enrollment target is 112 participants. The study started on 2020-08-03. Estimated completion is 2027-09-30.

What conditions does trial NCT04509700 study?

This clinical trial studies the following conditions: B-Cell Malignancies. These conditions were identified from the trial registry and reflect the primary focus areas of the research.

What interventions are being tested in trial NCT04509700?

The interventions under investigation include: Parsaclisib (DRUG), parsaclisib + itacitinib (DRUG), parsaclisib + ruxolitinib (DRUG), parsaclisib + ibrutinib (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.

Who is sponsoring clinical trial NCT04509700?

This trial is sponsored by Incyte Corporation, which has 163 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.

Where is trial NCT04509700 being conducted?

This trial has 20 study locations across Alabama, Arizona, California, Colorado, Illinois. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial