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Long-term Extension Study of Zanubrutinib (BGB-3111) Regimens in Participants With B-cell Malignancies
NCT04170283 · View on ClinicalTrials.gov ↗
Study Summary
The purpose of this study is to evaluate the long-term safety of zanubrutinib regimens in participants with B-cell malignancies who participated in a BeiGene parent study for zanubrutinib.
Conditions Studied
Interventions
- DRUG Zanubrutinib
- DRUG Tislelizumab
Study Locations (20)
Colorado
- Rocky Mountain Cancer Centers Centennial — Centennial
- Colorado Blood Cancer Institute — Denver
Florida
- Florida Cancer Specialists Fort Myers — Fort Myers
- Scri Florida Cancer Specialists North — St. Petersburg
New Jersey
- Summit Medical Group — Florham Park
- Atlantic Health System — Morristown
Oregon
- Oncology Associates of Oregon Willamette Valley Cancer Center — Eugene
- Oregon Health and Science University — Portland
Tennessee
- Scri Tennessee Oncology Chattanooga — Chattanooga
- Tennessee Oncology — Nashville
Arizona
- Banner Md Anderson Cancer Center — Gilbert
Arkansas
- Carti Cancer Center — Little Rock
Massachusetts
- Dana Farber Cancer Institute — Boston
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 955 participants |
| Start Date | 2020-01-16 |
| Est. Completion | 2028-12 |
| Phase | Phase 3 |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT04170283
The ClinicalTrials.gov registry entry for NCT04170283 describes a study currently listed as active not recruiting. It is categorized as Phase 3, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 955 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is BeiGene, which has 91 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.
The record links to 1 condition, with B-cell Malignancies appearing as the primary indexed condition, and to 2 interventions — of which Zanubrutinib is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.
Geographic footprint matters for practical reasons: NCT04170283 reports 20 study locations spanning 15 distinct geographic areas — top geographies include Colorado, Florida, New Jersey. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.
Frequently Asked Questions
What is clinical trial NCT04170283 about?
NCT04170283 is a clinical study titled "Long-term Extension Study of Zanubrutinib (BGB-3111) Regimens in Participants With B-cell Malignancies". The purpose of this study is to evaluate the long-term safety of zanubrutinib regimens in participants with B-cell malignancies who participated in a BeiGene parent study for zanubrutinib.
What is the current status of trial NCT04170283?
This trial is currently active not recruiting. It is a Phase 3 study. The enrollment target is 955 participants. The study started on 2020-01-16. Estimated completion is 2028-12.
What conditions does trial NCT04170283 study?
This clinical trial studies the following conditions: B-cell Malignancies. These conditions were identified from the trial registry and reflect the primary focus areas of the research.
What interventions are being tested in trial NCT04170283?
The interventions under investigation include: Zanubrutinib (DRUG), Tislelizumab (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.
Who is sponsoring clinical trial NCT04170283?
This trial is sponsored by BeiGene, which has 91 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.
Where is trial NCT04170283 being conducted?
This trial has 20 study locations across Arizona, Arkansas, Colorado, Florida, Massachusetts. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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