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Non-interventional Study of Patients With Transthyretin (ATTR) Amyloidosis
NCT06465810 · View on ClinicalTrials.gov ↗
Study Summary
The MaesTTRo study aims to enroll a global cohort of patients with transthyretin (ATTR) amyloidosis to longitudinally observe the natural course of the disease and describe real-world treatment patterns and outcomes. In addition, information on the effectiveness of ATTR amyloidosis treatments, including eplontersen, which is a ligand-conjugated antisense oligonucleotide gene silencing treatment targeting activity against both the mutant and wild-type TTR protein, will be collected.
Conditions Studied
Interventions
- DRUG Treatment of transthyretin (ATTR) amyloidosis in observational study setting
Study Locations (20)
California
- Research Site — La Jolla
- Research Site — Los Angeles
- Research Site — San Francisco
- Research Site — San Francisco
Massachusetts
- Research Site — Boston
- Research Site — Boston
- Research Site — Boston
New York
- Research Site — Manhasset
- Research Site — New York
- Research Site — New York
Missouri
- Research Site — Kansas City
- Research Site — St Louis
Connecticut
- Research Site — New Haven
District of Columbia
- Research Site — Washington D.C.
Illinois
- Research Site — Chicago
Indiana
- Research Site — Indianapolis
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 1,850 participants |
| Start Date | 2024-06-25 |
| Est. Completion | 2031-12-29 |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT06465810
The ClinicalTrials.gov registry entry for NCT06465810 describes a study currently listed as recruiting. It is categorized as an unspecified phase, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 1,850 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is AstraZeneca, which has 1,053 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.
The record links to 6 conditions, with Transthyretin Amyloidosis appearing as the primary indexed condition, and to 1 intervention — of which Treatment of transthyretin (ATTR) amyloidosis in observational study setting is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.
Geographic footprint matters for practical reasons: NCT06465810 reports 20 study locations spanning 12 distinct geographic areas — top geographies include California, Massachusetts, New York. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.
Frequently Asked Questions
What is clinical trial NCT06465810 about?
NCT06465810 is a clinical study titled "Non-interventional Study of Patients With Transthyretin (ATTR) Amyloidosis". The MaesTTRo study aims to enroll a global cohort of patients with transthyretin (ATTR) amyloidosis to longitudinally observe the natural course of the disease and describe real-world treatment patterns and outcomes. In addition, information on the effectiveness of ATTR amyloidosis treatments, inclu...
What is the current status of trial NCT06465810?
This trial is currently recruiting. The enrollment target is 1,850 participants. The study started on 2024-06-25. Estimated completion is 2031-12-29.
What conditions does trial NCT06465810 study?
This clinical trial studies the following conditions: Transthyretin Amyloidosis, ATTR-CM, ATTRv-PN, ATTR, ATTR-Mixed. These conditions were identified from the trial registry and reflect the primary focus areas of the research.
What interventions are being tested in trial NCT06465810?
The interventions under investigation include: Treatment of transthyretin (ATTR) amyloidosis in observational study setting (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.
Who is sponsoring clinical trial NCT06465810?
This trial is sponsored by AstraZeneca, which has 1,053 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.
Where is trial NCT06465810 being conducted?
This trial has 20 study locations across California, Connecticut, District of Columbia, Illinois, Indiana. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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