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NCT05023889 · ClinicalTrials.gov registry record · Early Phase 1
Spectrum of Peripheral and Autonomic Neuropathies in Patients With aTTRwt Amyloidosis and Response to Patisiran Therapy
A Early Phase 1 study of Transthyretin Amyloidosis and Polyneuropathies, sponsored by Austin Neuromuscular Center.
- Active
- Registry status
- Early Phase 1
- Development phase
- 10
- Enrollment target
- 1
- Study location
NCT05023889: Active Early Phase 1 study of Transthyretin Amyloidosis and Polyneuropathies, sponsored by Austin Neuromuscular Center.
NCT05023889 is a Early Phase 1 study of Transthyretin Amyloidosis and Polyneuropathies that is active but no longer recruiting, run by Austin Neuromuscular Center. The registered enrollment target is 10 participants, below the 1,257-participant average among 8 other Transthyretin Amyloidosis trials with a reported enrollment target (99% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT05023889, a Early Phase 1 study of Transthyretin Amyloidosis and Polyneuropathies, is active but no longer recruiting, sponsored by Austin Neuromuscular Center.
- ACTIVE NOT RECRUITING
- Registry status
- Early Phase 1
- Development phase
- 10 participants
- Enrollment target
- 1
- Study location
Study Summary
To evaluate the efficacy and safety of patisiran in patients with wtATTR amyloidosis and symptomatic polyneuropathy by evaluating the effect on neurologic impairment and quality of life.
Primary Outcome
to assess the severity of functional impairment of motor and sensory nerves.NIS is a measure of motor strength, comprised of cranial nerve and both upper and lower limb motor assessments. The minimum and maximum values are 0 and 192, respectively. A higher score indicates a worse outcome.
Conditions Studied
Interventions
- DRUG patisiran
Study Locations (1)
Texas
- Austin Neuromuscler Center/National Neuromuscular Research Institute - Austin
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 10 participants |
| Start Date | 2022-08-03 |
| Est. Completion | 2026-02-25 |
| Phase | Early Phase 1 |
What the registry record for NCT05023889 still lists
NCT05023889 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 10 participants, a relatively small participant target, below the 1,257-participant average among 8 other Transthyretin Amyloidosis trials with a reported enrollment target (99% lower).
The record links to 5 conditions, with Transthyretin Amyloidosis appearing as the primary indexed condition, and to 1 intervention - of which patisiran is the first listed.
NCT05023889 reports a single indexed study location in Texas.
Frequently Asked Questions
What is clinical trial NCT05023889 about?
NCT05023889 is a clinical study titled "Spectrum of Peripheral and Autonomic Neuropathies in Patients With aTTRwt Amyloidosis and Response to Patisiran Therapy". To evaluate the efficacy and safety of patisiran in patients with wtATTR amyloidosis and symptomatic polyneuropathy by evaluating the effect on neurologic impairment and quality of life.
What is the current status of trial NCT05023889?
This trial is currently active not recruiting. It is a Early Phase 1 study. The enrollment target is 10 participants. The study started on 2022-08-03. Estimated completion is 2026-02-25.
What conditions does trial NCT05023889 study?
This clinical trial studies the following conditions: Transthyretin Amyloidosis, Polyneuropathies, Wild Type ATTR Amyloidosis, Wild-Type Transthyretin-Related (ATTR)Amyloidosis, Wild-Type Transthyretin Cardiac Amyloidosis.
What interventions are being tested in trial NCT05023889?
The interventions under investigation include: patisiran (DRUG).
Who is sponsoring clinical trial NCT05023889?
This trial is sponsored by Austin Neuromuscular Center, which has 2 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT05023889 being conducted?
This trial has 1 study location across Texas. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
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Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT05023889's enrollment target sits among peer trials
10 8th of 8 higher than 1 of 8 other Transthyretin Amyloidosis trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Transthyretin Amyloidosis trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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