Medical Information Only. Always consult your healthcare provider before enrolling in any clinical trial.
NCT06434519 · ClinicalTrials.gov registry record · NA
Metronidazole SC Penetrance With Moisturizers
A NA study, sponsored by Duke University.
- Completed
- Registry status
- NA
- Development phase
- 21
- Enrollment target
NCT06434519 is a NA study that has completed, run by Duke University. The registered enrollment target is 21 participants.
The verdict
NCT06434519, a NA study, has completed, sponsored by Duke University.
- COMPLETED
- Registry status
- NA
- Development phase
- 21 participants
- Enrollment target
Study Summary
Topical metronidazole is a widely used first line treatment for erythemotelangiectatic and inflammatory rosacea. Commonly, a moisturizer is also used to restore the skin barrier and reduce inflammation. The purpose of this study is to assess the whether the common practice of applying moisturizer prior to topical metronidazole affects this medication's stratum corneum penetrance in rosacea patients. Participants will have one research office visit that will consist of having a randomly assigned combination of metronidazole and one of four moisturizers applied to their face, followed by non-invasive tape stripping of skin at the 1 hour and 4 hour time points. These tape strip samples will be analyzed with liquid chromatography mass spectrometry (LC-MS) for assessment of metronidazole penetrance in the stratum corneum in the presence of moisturizers. The target population will be rosacea patients in the age range of 18-60 years of age. This study has minimal risks/safety issues as topical metronidazole is an already FDA approved medication with an indication for rosacea and all investigated moisturizers are over-the-counter formulations commonly used within the rosacea patient population. Tape stripping will remove 5 levels of superficial stratum corneum, and will not result in bleeding, scarring, or other prolonged cosmetic disfigurement. Small, transient bruising may result from tape strip collection. The collected samples will have no to minimal biohazard risk, as the collected specimen for analysis will only contain skin scale; samples will be extracted with organic solvents and decontaminated with a 0.2 micron nylon filter prior to analysis on the LC-MS instrumentation.
Interventions
- DRUG Metronidazole cream
- OTHER CeraVe moisturizer
- OTHER Cetaphil moisturizer
- OTHER Eucerin Healing Lotion moisturizer
- OTHER Aveeno Calm and Restore Oat Gel moisturizer
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 21 participants |
| Start Date | 2024-09-03 |
| Est. Completion | 2025-11-04 |
| Phase | NA |
Interested in This Trial?
Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT06434519
The ClinicalTrials.gov registry entry for NCT06434519 describes a study currently listed as completed, categorized as NA. The registered enrollment target is 21 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Duke University, which has 1,725 total studies on file at ClinicalTrials.gov.
The record links to 0 conditions, and to 5 interventions - of which Metronidazole cream is the first listed.
NCT06434519 reports 0 study locations.
Frequently Asked Questions
What is clinical trial NCT06434519 about?
NCT06434519 is a clinical study titled "Metronidazole SC Penetrance With Moisturizers". Topical metronidazole is a widely used first line treatment for erythemotelangiectatic and inflammatory rosacea. Commonly, a moisturizer is also used to restore the skin barrier and reduce inflammation. The purpose of this study is to assess the whether the common practice of applying moisturizer pr...
What is the current status of trial NCT06434519?
This trial is currently completed. It is a NA study. The enrollment target is 21 participants. The study started on 2024-09-03. Estimated completion is 2025-11-04.
What interventions are being tested in trial NCT06434519?
The interventions under investigation include: Metronidazole cream (DRUG), CeraVe moisturizer (OTHER), Cetaphil moisturizer (OTHER), Eucerin Healing Lotion moisturizer (OTHER), Aveeno Calm and Restore Oat Gel moisturizer (OTHER).
Who is sponsoring clinical trial NCT06434519?
This trial is sponsored by Duke University, which has 1,725 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
Explore more on PlainTrial
Read our methodology - how this data is sourced, computed, and verified.
Related
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page mirrors this trial's own ClinicalTrials.gov registry record, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.