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NCT06300996 · ClinicalTrials.gov registry record · NA
Spinal Cord Stimulation for the Treatment of Motor Deficits in People With Spinal Muscular Atrophy - Upper Limb
A NA study of Spinal Muscular Atrophy and Spinal Muscular Atrophy Type 3, sponsored by Marco Capogrosso.
- Active
- Registry status
- NA
- Development phase
- 3
- Enrollment target
- 1
- Study location
NCT06300996 is a NA study of Spinal Muscular Atrophy and Spinal Muscular Atrophy Type 3 that is active but no longer recruiting, run by Marco Capogrosso. The registered enrollment target is 3 participants, below the 109-participant average among 22 other Spinal Muscular Atrophy trials with a reported enrollment target (97% lower). The trial reports 1 study location across 1 state.
The verdict
NCT06300996, a NA study of Spinal Muscular Atrophy and Spinal Muscular Atrophy Type 3, is active but no longer recruiting, sponsored by Marco Capogrosso.
- ACTIVE NOT RECRUITING
- Registry status
- NA
- Development phase
- 3 participants
- Enrollment target
- 1
- Study location
Study Summary
Spinal cord stimulation (SCS) has shown remarkable efficacy in restoring motor function in people with spinal cord injury by recruiting afferent input to enhance the responsiveness of spared neural circuits to residual cortical inputs. This pilot will test if SCS can show evidence to improve motor deficits in people with Type 2, 3, or 4 spinal muscular atrophy (SMA). The investigators will enroll up to six subjects with Type 2, 3, or 4 SMA aged 16 or older that show quantifiable motor deficits of the upper body. The investigators will then implant the subjects with percutaneous, linear spinal leads near the cervical spinal cord for a period of up to 29 days. Although these leads are not optimized for motor function but rather for their clinically approved indication of treating pain, the investigators believe they provide a safe technology enabling our team to perform scientific measurement necessary to evaluate potential for effects of SCS in motor paralysis with SMA. After the end of the study, the leads will be explanted.
Conditions Studied
Interventions
- DEVICE Spinal Cord Stimulator (Octopolar Medtronic Vectris Leads)
Study Locations (1)
Pennsylvania
- University of Pittsburgh - Pittsburgh
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 3 participants |
| Start Date | 2024-05-31 |
| Est. Completion | 2029-09 |
| Phase | NA |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT06300996
The ClinicalTrials.gov registry entry for NCT06300996 describes a study currently listed as active not recruiting, categorized as NA. The registered enrollment target is 3 participants, a figure that helps gauge the scale of data the investigators plan to collect, below the 109-participant average among 22 other Spinal Muscular Atrophy trials with a reported enrollment target (97% lower). The listed sponsor is Marco Capogrosso, which has 3 total studies on file at ClinicalTrials.gov.
The record links to 5 conditions, with Spinal Muscular Atrophy appearing as the primary indexed condition, and to 1 intervention - of which Spinal Cord Stimulator (Octopolar Medtronic Vectris Leads) is the first listed.
NCT06300996 reports 1 study location spanning 1 distinct geographic area - top geographies include Pennsylvania.
Frequently Asked Questions
What is clinical trial NCT06300996 about?
NCT06300996 is a clinical study titled "Spinal Cord Stimulation for the Treatment of Motor Deficits in People With Spinal Muscular Atrophy - Upper Limb". Spinal cord stimulation (SCS) has shown remarkable efficacy in restoring motor function in people with spinal cord injury by recruiting afferent input to enhance the responsiveness of spared neural circuits to residual cortical inputs. This pilot will test if SCS can show evidence to improve motor d...
What is the current status of trial NCT06300996?
This trial is currently active not recruiting. It is a NA study. The enrollment target is 3 participants. The study started on 2024-05-31. Estimated completion is 2029-09.
What conditions does trial NCT06300996 study?
This clinical trial studies the following conditions: Spinal Muscular Atrophy, Spinal Muscular Atrophy Type 3, SMA, Spinal Muscular Atrophy Type II, Spinal Muscular Atrophy 4.
What interventions are being tested in trial NCT06300996?
The interventions under investigation include: Spinal Cord Stimulator (Octopolar Medtronic Vectris Leads) (DEVICE).
Who is sponsoring clinical trial NCT06300996?
This trial is sponsored by Marco Capogrosso, which has 3 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT06300996 being conducted?
This trial has 1 study location across Pennsylvania. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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