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NCT06249984 · ClinicalTrials.gov registry record · NA
Effects of Tobacco Cut and Nicotine Form on the Abuse Liability of Moist Snuff
A NA study of Tobacco-Related Carcinoma, sponsored by Ohio State University Comprehensive Cancer Center.
- Recruiting
- Registry status
- NA
- Development phase
- 80
- Enrollment target
- 2
- Study locations
NCT06249984: Recruiting NA study of Tobacco-Related Carcinoma, sponsored by Ohio State University Comprehensive Cancer Center.
NCT06249984 is a NA study of Tobacco-Related Carcinoma that is actively recruiting participants, run by Ohio State University Comprehensive Cancer Center. The registered enrollment target is 80 participants, below the 1,501-participant average among 10 other Tobacco-Related Carcinoma trials with a reported enrollment target (95% lower). The trial reports 2 study locations across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT06249984, a NA study of Tobacco-Related Carcinoma, is actively recruiting participants, sponsored by Ohio State University Comprehensive Cancer Center.
- RECRUITING
- Registry status
- NA
- Development phase
- 80 participants
- Enrollment target
- 2
- Study locations
Study Summary
This clinical trial tests the effects of tobacco cut and nicotine form on the abuse liability in participants who use moist snuff (smokeless tobacco \[SLT\]). Two features of moist snuff that are key targets of manipulation from the tobacco industry and drivers of its addiction potential are length of tobacco cut (long versus fine) and nicotine form (low versus high levels of nicotine in the free-base form). Finer tobacco cuts and higher levels of free-base nicotine (FBN) result in faster, greater nicotine delivery. Researchers want to gain information on how certain characteristics of moist snuff affect how long people use it, how it delivers nicotine, or how much people like it. This clinical trial may provide justifications for local, state, or federal regulations aimed at reducing the appeal and addictiveness of moist snuff.
Primary Outcome
Will be assessed by a randomized 2x2 within-subjects design to test whether variations in cut and level of FBN are associated with product use among Appalachian moist snuff users. Data will be summarized descriptively, overall and stratified by dependence. The investigators will use linear mixed effects models to assess the main effects of FBN content on moist snuff use duration and amount, self-reported measures, and plasma nicotine delivery (i.e., maximum absorption; total absorption; and spee
Conditions Studied
Interventions
- PROCEDURE Biospecimen Collection
- OTHER Survey Administration
- PROCEDURE Carbon Monoxide Measurement
- BEHAVIORAL Smokeless Tobacco Use
Study Locations (2)
Ohio
- Ohio State University Comprehensive Cancer Center - Columbus
- Center for Tobacco Research - Columbus
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 80 participants |
| Start Date | 2024-12-20 |
| Est. Completion | 2028-01-31 |
| Phase | NA |
What NCT06249984 shows while recruiting
NCT06249984 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 80 participants, a relatively small participant target, below the 1,501-participant average among 10 other Tobacco-Related Carcinoma trials with a reported enrollment target (95% lower).
The record links to 1 condition, with Tobacco-Related Carcinoma appearing as the primary indexed condition, and to 4 interventions - of which Biospecimen Collection is the first listed.
NCT06249984 reports a single indexed study location in Ohio.
Frequently Asked Questions
What is clinical trial NCT06249984 about?
NCT06249984 is a clinical study titled "Effects of Tobacco Cut and Nicotine Form on the Abuse Liability of Moist Snuff". This clinical trial tests the effects of tobacco cut and nicotine form on the abuse liability in participants who use moist snuff (smokeless tobacco \[SLT\]). Two features of moist snuff that are key targets of manipulation from the tobacco industry and drivers of its addiction potential are length ...
What is the current status of trial NCT06249984?
This trial is currently recruiting. It is a NA study. The enrollment target is 80 participants. The study started on 2024-12-20. Estimated completion is 2028-01-31.
What conditions does trial NCT06249984 study?
This clinical trial studies the following conditions: Tobacco-Related Carcinoma.
What interventions are being tested in trial NCT06249984?
The interventions under investigation include: Biospecimen Collection (PROCEDURE), Survey Administration (OTHER), Carbon Monoxide Measurement (PROCEDURE), Smokeless Tobacco Use (BEHAVIORAL).
Who is sponsoring clinical trial NCT06249984?
This trial is sponsored by Ohio State University Comprehensive Cancer Center, which has 341 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT06249984 being conducted?
This trial has 2 study locations across Ohio. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Tobacco-Related Carcinoma
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT06249984's enrollment target sits among peer trials
80 11th of 10 the lowest of 10 other Tobacco-Related Carcinoma trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Tobacco-Related Carcinoma trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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