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NCT06190691 · ClinicalTrials.gov registry record · Phase 1
Study of Pirtobrutinib (LOXO-305) in Participants With Impaired Liver Function and Healthy Participants
A Phase 1 study, sponsored by Eli Lilly and Company.
- Completed
- Registry status
- Phase 1
- Development phase
- 36
- Enrollment target
NCT06190691: Completed Phase 1 study, sponsored by Eli Lilly and Company.
NCT06190691 is a Phase 1 study that has completed, run by Eli Lilly and Company. The registered enrollment target is 36 participants, below the 60-participant average among 29,502 other Phase 1 trials with a reported enrollment target (40% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT06190691, a Phase 1 study, has completed, sponsored by Eli Lilly and Company.
- COMPLETED
- Registry status
- Phase 1
- Development phase
- 36 participants
- Enrollment target
Study Summary
The main purpose of this study is to measure how much of pirtobrutinib (LOXO-305) gets into the bloodstream and how long it takes the body to eliminate it in participants with impaired liver function and healthy participants. The side effects and tolerability of pirtobrutinib will also be evaluated. Participation could last about 46 days.
Primary Outcome
PK: Cmax of pirtobrutinib
Interventions
- DRUG Pirtobrutinib
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 36 participants |
| Start Date | 2020-12-18 |
| Est. Completion | 2021-12-30 |
| Phase | Phase 1 |
What the finished NCT06190691 record still lists
NCT06190691 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 36 participants, a relatively small participant target, below the 60-participant average among 29,502 other Phase 1 trials with a reported enrollment target (40% lower).
The record links to 0 conditions, and to 1 intervention - of which Pirtobrutinib is the first listed.
NCT06190691 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT06190691 about?
NCT06190691 is a clinical study titled "Study of Pirtobrutinib (LOXO-305) in Participants With Impaired Liver Function and Healthy Participants". The main purpose of this study is to measure how much of pirtobrutinib (LOXO-305) gets into the bloodstream and how long it takes the body to eliminate it in participants with impaired liver function and healthy participants. The side effects and tolerability of pirtobrutinib will also be evaluated....
What is the current status of trial NCT06190691?
This trial is currently completed. It is a Phase 1 study. The enrollment target is 36 participants. The study started on 2020-12-18. Estimated completion is 2021-12-30.
What interventions are being tested in trial NCT06190691?
The interventions under investigation include: Pirtobrutinib (DRUG).
Who is sponsoring clinical trial NCT06190691?
This trial is sponsored by Eli Lilly and Company, which has 1,341 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT06190691's enrollment target sits among peer trials
36 1210th of 2000 higher than 743 of 2,000 other Phase 1 trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Phase 1 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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