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NCT06136247 · ClinicalTrials.gov registry record

Integrating Brain, Neurocognitive, and Computational Tools in OUD

A clinical trial of Opioid Use Disorder, sponsored by University of Pennsylvania.

Recruiting
Registry status
192
Enrollment target
1
Study location

NCT06136247 is a study of Opioid Use Disorder that is actively recruiting participants, run by University of Pennsylvania. The registered enrollment target is 192 participants, below the 4,656-participant average among 257 other Opioid Use Disorder trials with a reported enrollment target (96% lower). The trial reports 1 study location across 1 state.

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The verdict

NCT06136247, a study of Opioid Use Disorder, is actively recruiting participants, sponsored by University of Pennsylvania.

RECRUITING
Registry status
192 participants
Enrollment target
1
Study location

Study Summary

The 5-year K01 Mentored Research Scientist proposal will employ brain, neurocognitive, and computational tools (e.g., machine learning) to understand the impact of opioid-use disorder (OUD) and common co-occurring issues on executive function and clinical outcomes. There have been record numbers of fatal and non-fatal overdoses (ODs) associated with opioids (and other drugs) in the past 12-months. Improving classification and predictive capabilities to enhance treatment and prevent relapse is of the upmost importance. Deficits in neurocognition often are associated with poor treatment outcomes (e.g., more drug use, medication non-adherence), yet co-occurring issues associated with OUD (e.g., depression, anxiety, physical/sexual abuse, neglect) make it difficult to parse which contributing factors lead to worse executive function (EF) and poorer treatment outcomes. Novel brain, neurocognitive, and computational tools are needed to help determine these differences, in order to lay the foundation for better treatments. This need has shaped both the training plan and the associated research project in a 5-year K01 Mentored Research Scientist proposal, building on Dr. Regier's prior preclinical and clinical addiction neuroscience experience (focused mostly on cocaine-use disorders, cue-reactivity, subcortical networks, prior adversity, and univariate imaging techniques).

Conditions Studied

Opioid Use Disorder

Interventions

  • DIAGNOSTIC_TEST Neurocognitive battery
  • DIAGNOSTIC_TEST fNIRS

Study Locations (1)

Pennsylvania

  • University of Pennsylvania - Philadelphia

Trial Details

FieldValue
Enrollment Target 192 participants
Start Date 2023-11-01
Est. Completion 2027-07-31

Sponsor

University of Pennsylvania

1,423 total trials

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Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT06136247

The ClinicalTrials.gov registry entry for NCT06136247 describes a study currently listed as recruiting, categorized as an unspecified phase. The registered enrollment target is 192 participants, a figure that helps gauge the scale of data the investigators plan to collect, below the 4,656-participant average among 257 other Opioid Use Disorder trials with a reported enrollment target (96% lower). The listed sponsor is University of Pennsylvania, which has 1,423 total studies on file at ClinicalTrials.gov.

The record links to 1 condition, with Opioid Use Disorder appearing as the primary indexed condition, and to 2 interventions - of which Neurocognitive battery is the first listed.

NCT06136247 reports 1 study location spanning 1 distinct geographic area - top geographies include Pennsylvania.

Frequently Asked Questions

What is clinical trial NCT06136247 about?

NCT06136247 is a clinical study titled "Integrating Brain, Neurocognitive, and Computational Tools in OUD". The 5-year K01 Mentored Research Scientist proposal will employ brain, neurocognitive, and computational tools (e.g., machine learning) to understand the impact of opioid-use disorder (OUD) and common co-occurring issues on executive function and clinical outcomes. There have been record numbers of ...

What is the current status of trial NCT06136247?

This trial is currently recruiting. The enrollment target is 192 participants. The study started on 2023-11-01. Estimated completion is 2027-07-31.

What conditions does trial NCT06136247 study?

This clinical trial studies the following conditions: Opioid Use Disorder.

What interventions are being tested in trial NCT06136247?

The interventions under investigation include: Neurocognitive battery (DIAGNOSTIC_TEST), fNIRS (DIAGNOSTIC_TEST).

Who is sponsoring clinical trial NCT06136247?

This trial is sponsored by University of Pennsylvania, which has 1,423 total clinical trials registered on ClinicalTrials.gov.

Where is trial NCT06136247 being conducted?

This trial has 1 study location across Pennsylvania. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

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Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page mirrors this trial's own ClinicalTrials.gov registry record, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.