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NCT06136247 · ClinicalTrials.gov registry record
Integrating Brain, Neurocognitive, and Computational Tools in OUD
A clinical trial of Opioid Use Disorder, sponsored by University of Pennsylvania.
- Recruiting
- Registry status
- 192
- Enrollment target
- 1
- Study location
NCT06136247: Recruiting study of Opioid Use Disorder, sponsored by University of Pennsylvania.
NCT06136247 is a study of Opioid Use Disorder that is actively recruiting participants, run by University of Pennsylvania. The registered enrollment target is 192 participants, below the 4,656-participant average among 257 other Opioid Use Disorder trials with a reported enrollment target (96% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT06136247, a study of Opioid Use Disorder, is actively recruiting participants, sponsored by University of Pennsylvania.
- RECRUITING
- Registry status
- 192 participants
- Enrollment target
- 1
- Study location
Study Summary
The 5-year K01 Mentored Research Scientist proposal will employ brain, neurocognitive, and computational tools (e.g., machine learning) to understand the impact of opioid-use disorder (OUD) and common co-occurring issues on executive function and clinical outcomes. There have been record numbers of fatal and non-fatal overdoses (ODs) associated with opioids (and other drugs) in the past 12-months. Improving classification and predictive capabilities to enhance treatment and prevent relapse is of the upmost importance. Deficits in neurocognition often are associated with poor treatment outcomes (e.g., more drug use, medication non-adherence), yet co-occurring issues associated with OUD (e.g., depression, anxiety, physical/sexual abuse, neglect) make it difficult to parse which contributing factors lead to worse executive function (EF) and poorer treatment outcomes. Novel brain, neurocognitive, and computational tools are needed to help determine these differences, in order to lay the foundation for better treatments. This need has shaped both the training plan and the associated research project in a 5-year K01 Mentored Research Scientist proposal, building on Dr. Regier's prior preclinical and clinical addiction neuroscience experience (focused mostly on cocaine-use disorders, cue-reactivity, subcortical networks, prior adversity, and univariate imaging techniques).
Primary Outcome
Patient self report of drug use on the weekly Follow Up Survey- days per week having taken any drugs
Conditions Studied
Interventions
- DIAGNOSTIC_TEST Neurocognitive battery
- DIAGNOSTIC_TEST fNIRS
Study Locations (1)
Pennsylvania
- University of Pennsylvania - Philadelphia
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 192 participants |
| Start Date | 2023-11-01 |
| Est. Completion | 2027-07-31 |
What NCT06136247 shows while recruiting
NCT06136247 is an observational study that tracks outcomes without assigning an intervention. The registered 192 participants enrollment target is mid-sized for trials with a published cap, below the 4,656-participant average among 257 other Opioid Use Disorder trials with a reported enrollment target (96% lower).
The record links to 1 condition, with Opioid Use Disorder appearing as the primary indexed condition, and to 2 interventions - of which Neurocognitive battery is the first listed.
NCT06136247 reports a single indexed study location in Pennsylvania.
Frequently Asked Questions
What is clinical trial NCT06136247 about?
NCT06136247 is a clinical study titled "Integrating Brain, Neurocognitive, and Computational Tools in OUD". The 5-year K01 Mentored Research Scientist proposal will employ brain, neurocognitive, and computational tools (e.g., machine learning) to understand the impact of opioid-use disorder (OUD) and common co-occurring issues on executive function and clinical outcomes. There have been record numbers of ...
What is the current status of trial NCT06136247?
This trial is currently recruiting. The enrollment target is 192 participants. The study started on 2023-11-01. Estimated completion is 2027-07-31.
What conditions does trial NCT06136247 study?
This clinical trial studies the following conditions: Opioid Use Disorder.
What interventions are being tested in trial NCT06136247?
The interventions under investigation include: Neurocognitive battery (DIAGNOSTIC_TEST), fNIRS (DIAGNOSTIC_TEST).
Who is sponsoring clinical trial NCT06136247?
This trial is sponsored by University of Pennsylvania, which has 1,423 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT06136247 being conducted?
This trial has 1 study location across Pennsylvania. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
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Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT06136247's enrollment target sits among peer trials
192 97th of 257 higher than 161 of 257 other Opioid Use Disorder trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Opioid Use Disorder trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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