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NCT06088758 · ClinicalTrials.gov registry record · NA
Normothermic Machine Perfusion of Steatotic Livers for Expansion of Donor Organ Pool
A NA study of Liver Transplant, sponsored by Massachusetts General Hospital.
- Recruiting
- Registry status
- NA
- Development phase
- 200
- Enrollment target
- 1
- Study location
NCT06088758: Recruiting NA study of Liver Transplant, sponsored by Massachusetts General Hospital.
NCT06088758 is a NA study of Liver Transplant that is actively recruiting participants, run by Massachusetts General Hospital. The registered enrollment target is 200 participants, below the 5,448-participant average among 19 other Liver Transplant trials with a reported enrollment target (96% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT06088758, a NA study of Liver Transplant, is actively recruiting participants, sponsored by Massachusetts General Hospital.
- RECRUITING
- Registry status
- NA
- Development phase
- 200 participants
- Enrollment target
- 1
- Study location
Study Summary
The goal of this clinical trial is to assess the ability of Normothermic Machine Perfusion (NMP) to resuscitate moderately steatotic livers for transplantation in patients. This will be a single-site clinical trial placing donor livers with 30-60% macrosteatosis on NMP, and then transplanting those that meet commonly accepted viability criteria. The results of this study could lead to a trial extending NMP transplantation to severely steatotic livers, further expanding the donor organ pool.
Primary Outcome
Number of participants with initial poor function of liver allograft: measured by presence of 1 or more of the following: aspartate aminotransferase (AST) level higher than 2000 IU/L (to convert to microkatals per liter, multiply by 0.0167) within the first 7 postoperative days; bilirubin 10 mg/dL or higher (to convert to micromoles per liter, multiply by 17.104) on postoperative day 7; international normalized ratio (INR) of 1.6 or higher on postoperative day 7; or graft primary nonfunction wit
Conditions Studied
Interventions
- DEVICE Normothermic machine perfusion (NMP) of steatotic liver
Study Locations (1)
Massachusetts
- Massachusetts General Brigham - Boston
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 200 participants |
| Start Date | 2024-02-28 |
| Est. Completion | 2027-07-31 |
| Phase | NA |
What NCT06088758 shows while recruiting
NCT06088758 is an interventional study that assigns participants to a tested intervention. The registered 200 participants enrollment target is mid-sized for trials with a published cap, below the 5,448-participant average among 19 other Liver Transplant trials with a reported enrollment target (96% lower).
The record links to 1 condition, with Liver Transplant appearing as the primary indexed condition, and to 1 intervention - of which Normothermic machine perfusion (NMP) of steatotic liver is the first listed.
NCT06088758 reports a single indexed study location in Massachusetts.
Frequently Asked Questions
What is clinical trial NCT06088758 about?
NCT06088758 is a clinical study titled "Normothermic Machine Perfusion of Steatotic Livers for Expansion of Donor Organ Pool". The goal of this clinical trial is to assess the ability of Normothermic Machine Perfusion (NMP) to resuscitate moderately steatotic livers for transplantation in patients. This will be a single-site clinical trial placing donor livers with 30-60% macrosteatosis on NMP, and then transplanting those ...
What is the current status of trial NCT06088758?
This trial is currently recruiting. It is a NA study. The enrollment target is 200 participants. The study started on 2024-02-28. Estimated completion is 2027-07-31.
What conditions does trial NCT06088758 study?
This clinical trial studies the following conditions: Liver Transplant.
What interventions are being tested in trial NCT06088758?
The interventions under investigation include: Normothermic machine perfusion (NMP) of steatotic liver (DEVICE).
Who is sponsoring clinical trial NCT06088758?
This trial is sponsored by Massachusetts General Hospital, which has 2,032 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT06088758 being conducted?
This trial has 1 study location across Massachusetts. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Liver Transplant
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT06088758's enrollment target sits among peer trials
200 8th of 19 higher than 12 of 19 other Liver Transplant trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Liver Transplant trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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