Medical Information Only. Always consult your healthcare provider before enrolling in any clinical trial.
Study of the Bria-IMT Regimen and CPI vs Physicians' Choice in Advanced Metastatic Breast Cancer.
NCT06072612 · View on ClinicalTrials.gov ↗
Study Summary
This is a multicenter randomized, open label study to evaluate overall survival with the Bria-IMT regimen in combination with Checkpoint Inhibitor \[Retifanlimab\], versus Treatment of Patients'/Physicians' Choice (TPC) in advanced metastatic or locally recurrent breast cancer (aMBC) patients with no approved alternative therapies available.
Conditions Studied
Interventions
- DRUG Cyclophosphamide
- DRUG Retifanlimab
- BIOLOGICAL SV-BR-1-GM
- DRUG Interferon infiltration of the inoculation site
- DRUG Treatment of Physician's Choice
Study Locations (20)
California
- Los Angeles cancer Network_Anaheim — Anaheim
- Comprehensive Blood and Cancer Center — Bakersfield
- Cedars-Sinai Cancer Beverly Hills — Beverly Hills
- Los Angeles Cancer Network_Corona — Corona
- Los Angeles cancer Network_Fountain Vallley — Fountain Valley
- Los Angeles Cancer Network_Glendale — Glendale
- Hoag Hospital Center — Irvine
- Hoag Hospital Irvine — Irvine
- Los Angeles Cancer Network — Los Angeles
- Cedars-Sinai Cancer at Cedars-Sinai Medical Facility — Los Angeles
- Los Angeles Cancer Network_Century City — Los Angeles
- UCLA-Hematology/Oncology Medical Plaza — Los Angeles
- UCLA-Hematology/Oncology_LA 2 — Los Angeles
- UCLA-Hematology/Oncology_LA — Los Angeles
- Los Angeles Cancer Network_Pasadena — Pasadena
- Los Angeles cancer Network_Riverside — Riverside
- UC San Diego — San Diego
- St. John's Cancer Center — Santa Monica
Arizona
- Mayo Clinic-Comprehensive Cancer Center-Breast Clinic — Phoenix
- University of Arizona-Cancer Center — Tucson
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 404 participants |
| Start Date | 2023-12-05 |
| Est. Completion | 2028-06 |
| Phase | Phase 3 |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT06072612
The ClinicalTrials.gov registry entry for NCT06072612 describes a study currently listed as recruiting. It is categorized as Phase 3, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 404 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is BriaCell Therapeutics Corporation, which has 2 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.
The record links to 5 conditions, with Breast Cancer appearing as the primary indexed condition, and to 5 interventions — of which Cyclophosphamide is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.
Geographic footprint matters for practical reasons: NCT06072612 reports 20 study locations spanning 2 distinct geographic areas — top geographies include California, Arizona. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.
Frequently Asked Questions
What is clinical trial NCT06072612 about?
NCT06072612 is a clinical study titled "Study of the Bria-IMT Regimen and CPI vs Physicians' Choice in Advanced Metastatic Breast Cancer.". This is a multicenter randomized, open label study to evaluate overall survival with the Bria-IMT regimen in combination with Checkpoint Inhibitor \[Retifanlimab\], versus Treatment of Patients'/Physicians' Choice (TPC) in advanced metastatic or locally recurrent breast cancer (aMBC) patients with n...
What is the current status of trial NCT06072612?
This trial is currently recruiting. It is a Phase 3 study. The enrollment target is 404 participants. The study started on 2023-12-05. Estimated completion is 2028-06.
What conditions does trial NCT06072612 study?
This clinical trial studies the following conditions: Breast Cancer, Metastatic Breast Cancer, Breast Neoplasm, Breast Cancer Metastatic, End Stage Cancer. These conditions were identified from the trial registry and reflect the primary focus areas of the research.
What interventions are being tested in trial NCT06072612?
The interventions under investigation include: Cyclophosphamide (DRUG), Retifanlimab (DRUG), SV-BR-1-GM (BIOLOGICAL), Interferon infiltration of the inoculation site (DRUG), Treatment of Physician's Choice (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.
Who is sponsoring clinical trial NCT06072612?
This trial is sponsored by BriaCell Therapeutics Corporation, which has 2 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.
Where is trial NCT06072612 being conducted?
This trial has 20 study locations across Arizona, California. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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