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NCT05878457 · ClinicalTrials.gov registry record · Phase 1

Accelerated rTMS for Post-Stroke Apathy

A Phase 1 study of Motivation and Stroke Sequelae, sponsored by Medical University of South Carolina.

Completed
Registry status
Phase 1
Development phase
14
Enrollment target
1
Study location

NCT05878457: Completed Phase 1 study of Motivation and Stroke Sequelae, sponsored by Medical University of South Carolina.

NCT05878457 is a Phase 1 study of Motivation and Stroke Sequelae that has completed, run by Medical University of South Carolina. The registered enrollment target is 14 participants, below the 141-participant average among 13 other Motivation trials with a reported enrollment target (90% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.

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The verdict

NCT05878457, a Phase 1 study of Motivation and Stroke Sequelae, has completed, sponsored by Medical University of South Carolina.

COMPLETED
Registry status
Phase 1
Development phase
14 participants
Enrollment target
1
Study location

Study Summary

This pilot study will investigate the safety, feasibility, tolerability, and preliminary efficacy of accelerated high-dose repetitive transcranial magnetic stimulation (rTMS) targeting the medial prefrontal cortex (mPFC) to address apathy symptoms in individuals with chronic stroke.

Primary Outcome

The Lille Apathy Rating Scale (LARS) is a validated 33-item structured interview assessing apathy across 9 domains, including intellectual curiosity, emotion, action initiation, self-awareness, productivity, interests, novelty seeking, motivation, and social engagement. Total scores range from -36 to +36, with higher scores indicating greater severity of apathy (worse outcome) and lower (more negative) scores indicating less apathy (better outcome). The total score is calculated by summing res

Conditions Studied

Motivation Stroke Sequelae Apathy Stroke/Brain Attack Abulia Stroke (CVA) or TIA

Interventions

  • DEVICE MagVenture MagPro Transcranial Magnetic Stimulation (TMS) System

Study Locations (1)

South Carolina

  • Medical University of South Carolina Brain Stimulation Lab - Charleston

Trial Details

FieldValue
Enrollment Target 14 participants
Start Date 2023-12-01
Est. Completion 2025-04-30
Phase Phase 1
Medical University of South Carolina

755 total trials

What the finished NCT05878457 record still lists

NCT05878457 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 14 participants, a relatively small participant target, below the 141-participant average among 13 other Motivation trials with a reported enrollment target (90% lower).

The record links to 6 conditions, with Motivation appearing as the primary indexed condition, and to 1 intervention - of which MagVenture MagPro Transcranial Magnetic Stimulation (TMS) System is the first listed.

NCT05878457 reports a single indexed study location in South Carolina.

Frequently Asked Questions

What is clinical trial NCT05878457 about?

NCT05878457 is a clinical study titled "Accelerated rTMS for Post-Stroke Apathy". This pilot study will investigate the safety, feasibility, tolerability, and preliminary efficacy of accelerated high-dose repetitive transcranial magnetic stimulation (rTMS) targeting the medial prefrontal cortex (mPFC) to address apathy symptoms in individuals with chronic stroke.

What is the current status of trial NCT05878457?

This trial is currently completed. It is a Phase 1 study. The enrollment target is 14 participants. The study started on 2023-12-01. Estimated completion is 2025-04-30.

What conditions does trial NCT05878457 study?

This clinical trial studies the following conditions: Motivation, Stroke Sequelae, Apathy, Stroke/Brain Attack, Abulia.

What interventions are being tested in trial NCT05878457?

The interventions under investigation include: MagVenture MagPro Transcranial Magnetic Stimulation (TMS) System (DEVICE).

Who is sponsoring clinical trial NCT05878457?

This trial is sponsored by Medical University of South Carolina, which has 755 total clinical trials registered on ClinicalTrials.gov.

Where is trial NCT05878457 being conducted?

This trial has 1 study location across South Carolina. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Learn More About Clinical Trials

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Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.

Where NCT05878457's enrollment target sits among peer trials

14 13th of 13 the lowest of 13 other Motivation trials

participants (enrollment target), bucketed by value

Each bar is a band; taller bars hold more other Motivation trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.

Source ClinicalTrials.gov registry export · 2026-08-08

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Related registry views

Source: ClinicalTrials.gov NCT05878457, the US trial registry maintained by the National Library of Medicine. NCT05878457 (small enrollment · single site footprint · completed) retrieved and formatted by PlainTrial, see methodology.