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NCT05049837 · ClinicalTrials.gov registry record
PROSPECT - Profiling of Resistance Patterns & Oncogenic Signaling Pathways in Evaluation of Cancers of the Thorax and Therapeutic Target Identification
A clinical trial of Lung Cancer and Cancer of Thorax, sponsored by M.D. Anderson Cancer Center.
- Recruiting
- Registry status
- 7,200
- Enrollment target
- 1
- Study location
NCT05049837: Recruiting study of Lung Cancer and Cancer of Thorax, sponsored by M.D. Anderson Cancer Center.
NCT05049837 is a study of Lung Cancer and Cancer of Thorax that is actively recruiting participants, run by M.D. Anderson Cancer Center. The registered enrollment target is 7,200 participants, above the 918-participant average among 409 other Lung Cancer trials with a reported enrollment target (684% higher). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT05049837, a study of Lung Cancer and Cancer of Thorax, is actively recruiting participants, sponsored by M.D. Anderson Cancer Center.
- RECRUITING
- Registry status
- 7,200 participants
- Enrollment target
- 1
- Study location
Study Summary
In this Project, we will use therapeutic target -focused (TTF) profiling, genome-wide mRNA profiling and assessments of tumor phosphopeptides and DNA that are shed into the blood stream to define how various molecular factors alone and in combination relate to resistance to therapy, to prognosis, and to metastatic patterns at relapse. We will examine how the presence of factors that drive cell growth, antagonize apoptosis, or confer resistance in other ways may counter the effect of systemic therapies and/or promote rapid tumor recurrence. In this way, we will identify new, previously unappreciated potential therapeutic targets while also identifying which targets are most likely to increase resistance to therapy and worsen prognosis.
Conditions Studied
Interventions
- OTHER Group Specific Aim 1
- OTHER Group Specific Aim 2
- OTHER Group Specific Aim 3
- OTHER Group Specific Aim 4
- OTHER Group Specific Aim 5
Study Locations (1)
Texas
- M D Anderson Caner Center - Houston
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 7,200 participants |
| Start Date | 2007-04-25 |
| Est. Completion | 2025-12-31 |
What NCT05049837 shows while recruiting
NCT05049837 is an observational study that tracks outcomes without assigning an intervention. Its 7,200 participants enrollment target places it among the larger protocols in the corpus, above the 918-participant average among 409 other Lung Cancer trials with a reported enrollment target (684% higher).
The record links to 2 conditions, with Lung Cancer appearing as the primary indexed condition, and to 5 interventions - of which Group Specific Aim 1 is the first listed.
NCT05049837 reports a single indexed study location in Texas.
Frequently Asked Questions
What is clinical trial NCT05049837 about?
NCT05049837 is a clinical study titled "PROSPECT - Profiling of Resistance Patterns & Oncogenic Signaling Pathways in Evaluation of Cancers of the Thorax and Therapeutic Target Identification". In this Project, we will use therapeutic target -focused (TTF) profiling, genome-wide mRNA profiling and assessments of tumor phosphopeptides and DNA that are shed into the blood stream to define how various molecular factors alone and in combination relate to resistance to therapy, to prognosis, an...
What is the current status of trial NCT05049837?
This trial is currently recruiting. The enrollment target is 7,200 participants. The study started on 2007-04-25. Estimated completion is 2025-12-31.
What conditions does trial NCT05049837 study?
This clinical trial studies the following conditions: Lung Cancer, Cancer of Thorax.
What interventions are being tested in trial NCT05049837?
The interventions under investigation include: Group Specific Aim 1 (OTHER), Group Specific Aim 2 (OTHER), Group Specific Aim 3 (OTHER), Group Specific Aim 4 (OTHER), Group Specific Aim 5 (OTHER).
Who is sponsoring clinical trial NCT05049837?
This trial is sponsored by M.D. Anderson Cancer Center, which has 2,692 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT05049837 being conducted?
This trial has 1 study location across Texas. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Lung Cancer
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT05049837's enrollment target sits among peer trials
7,200 12th of 409 higher than 398 of 409 other Lung Cancer trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Lung Cancer trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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