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NCT05506085 · ClinicalTrials.gov registry record

Deep Brain Stimulation for Laryngeal Dystonia: From Mechanism to Optimal Application

A clinical trial of Laryngeal Dystonia and Adductor Spastic Dysphonia of Dystonia, sponsored by Indiana University.

Recruiting
Registry status
12
Enrollment target
1
Study location

NCT05506085: Recruiting study of Laryngeal Dystonia and Adductor Spastic Dysphonia of Dystonia, sponsored by Indiana University.

NCT05506085 is a study of Laryngeal Dystonia and Adductor Spastic Dysphonia of Dystonia that is actively recruiting participants, run by Indiana University. The registered enrollment target is 12 participants, below the 108-participant average among 9 other Laryngeal Dystonia trials with a reported enrollment target (89% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.

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The verdict

NCT05506085, a study of Laryngeal Dystonia and Adductor Spastic Dysphonia of Dystonia, is actively recruiting participants, sponsored by Indiana University.

RECRUITING
Registry status
12 participants
Enrollment target
1
Study location

Study Summary

Deep Brain Stimulation (DBS) is a neurosurgical procedure used to treat tremors, and dystonia. This study will enroll people who have a form of focal dystonia that affects their vocal cords called Adductor Laryngeal dystonia (ADLD). Participants will undergo Deep Brain Stimulation surgery to treat laryngeal dystonia as part of their clinical care. Before surgery, as part of the study they will have specialized testing to study the movement of the vocal cords, as well as functional magnetic resonance imaging (fMRI). While in the operating room, researchers will examine brain waves to better understand how faulty brain firing patterns lead to dystonia. After surgery, and activation of the deep brain stimulator, participants will repeat speech testing and vocal cord imaging as well as magnetic resonance imaging (MRI).

Primary Outcome

Vocal fold movements will be quantified (vibratory breaks + micromotions+ aperiodicities) using high-speed videoendoscopy (HSV) on sustained phonation of the vowel, words, and sentence production. The videoendoscopic recording will be obtained

Conditions Studied

Laryngeal Dystonia Adductor Spastic Dysphonia of Dystonia

Interventions

  • DEVICE Deep Brain Stimulation

Study Locations (1)

Indiana

  • Indiana University - Indianapolis

Trial Details

FieldValue
Enrollment Target 12 participants
Start Date 2022-10-01
Est. Completion 2030-08-01
Indiana University

890 total trials

What NCT05506085 shows while recruiting

NCT05506085 is an observational study that tracks outcomes without assigning an intervention. The registry caps enrollment at 12 participants, a relatively small participant target, below the 108-participant average among 9 other Laryngeal Dystonia trials with a reported enrollment target (89% lower).

The record links to 2 conditions, with Laryngeal Dystonia appearing as the primary indexed condition, and to 1 intervention - of which Deep Brain Stimulation is the first listed.

NCT05506085 reports a single indexed study location in Indiana.

Frequently Asked Questions

What is clinical trial NCT05506085 about?

NCT05506085 is a clinical study titled "Deep Brain Stimulation for Laryngeal Dystonia: From Mechanism to Optimal Application". Deep Brain Stimulation (DBS) is a neurosurgical procedure used to treat tremors, and dystonia. This study will enroll people who have a form of focal dystonia that affects their vocal cords called Adductor Laryngeal dystonia (ADLD). Participants will undergo Deep Brain Stimulation surgery to treat l...

What is the current status of trial NCT05506085?

This trial is currently recruiting. The enrollment target is 12 participants. The study started on 2022-10-01. Estimated completion is 2030-08-01.

What conditions does trial NCT05506085 study?

This clinical trial studies the following conditions: Laryngeal Dystonia, Adductor Spastic Dysphonia of Dystonia.

What interventions are being tested in trial NCT05506085?

The interventions under investigation include: Deep Brain Stimulation (DEVICE).

Who is sponsoring clinical trial NCT05506085?

This trial is sponsored by Indiana University, which has 890 total clinical trials registered on ClinicalTrials.gov.

Where is trial NCT05506085 being conducted?

This trial has 1 study location across Indiana. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Learn More About Clinical Trials

Similar trials for Laryngeal Dystonia

Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.

Where NCT05506085's enrollment target sits among peer trials

12 9th of 9 higher than 1 of 9 other Laryngeal Dystonia trials

participants (enrollment target), bucketed by value

Each bar is a band; taller bars hold more other Laryngeal Dystonia trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.

Source ClinicalTrials.gov registry export · 2026-08-08

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More recruiting context for NCT05506085

Source: ClinicalTrials.gov NCT05506085, the US trial registry maintained by the National Library of Medicine. NCT05506085 (small enrollment · single site footprint · recruiting) retrieved and formatted by PlainTrial, see methodology.