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NCT03042975 · ClinicalTrials.gov registry record
Imaging Genetics of Laryngeal Dystonia
A clinical trial of Laryngeal Dystonia and Muscle Tension Dysphonia, sponsored by Kristina Simonyan.
- Recruiting
- Registry status
- 410
- Enrollment target
- 1
- Study location
NCT03042975 is a study of Laryngeal Dystonia and Muscle Tension Dysphonia that is actively recruiting participants, run by Kristina Simonyan. The registered enrollment target is 410 participants, above the 64-participant average among 9 other Laryngeal Dystonia trials with a reported enrollment target (541% higher). The trial reports 1 study location across 1 state.
The verdict
NCT03042975, a study of Laryngeal Dystonia and Muscle Tension Dysphonia, is actively recruiting participants, sponsored by Kristina Simonyan.
- RECRUITING
- Registry status
- 410 participants
- Enrollment target
- 1
- Study location
Study Summary
The contribution of genetic risk factors to the development of focal dystonias is evident. However, understanding of how variations in the causative gene expression lead to variations in brain abnormalities in different phenotypes of dystonia (e.g., familial, sporadic) remains limited. The research program of the investigators is set to determine the relationship between brain changes and genetic risk factors in laryngeal dystonia (or spasmodic dysphonia). The researchers use a novel approach of combined imaging genetics, next-generation DNA sequencing, and clinical-behavioral testing. The use of a cross-disciplinary approach as a tool for the discovery of the mediating neural mechanisms that bridge the gap from DNA sequence to the pathophysiology of dystonia holds a promise for the understanding of the mechanistic aspects of brain function affected by risk gene variants, which can be used reliably for the discovery of associated genes and neural integrity markers for this disorder. The expected outcome of this study may lead to better clinical management of this disorder, including its improved detection, accurate diagnosis, and assessment of the risk of developing dystonia in family members.
Conditions Studied
Interventions
- OTHER MRI
- PROCEDURE Blood draw
Study Locations (1)
Massachusetts
- Massachusetts Eye and Ear Infirmary - Boston
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 410 participants |
| Start Date | 2017-01-23 |
| Est. Completion | 2028-07-31 |
Interested in This Trial?
Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT03042975
The ClinicalTrials.gov registry entry for NCT03042975 describes a study currently listed as recruiting, categorized as an unspecified phase. The registered enrollment target is 410 participants, a figure that helps gauge the scale of data the investigators plan to collect, above the 64-participant average among 9 other Laryngeal Dystonia trials with a reported enrollment target (541% higher). The listed sponsor is Kristina Simonyan, which has 5 total studies on file at ClinicalTrials.gov.
The record links to 4 conditions, with Laryngeal Dystonia appearing as the primary indexed condition, and to 2 interventions - of which MRI is the first listed.
NCT03042975 reports 1 study location spanning 1 distinct geographic area - top geographies include Massachusetts.
Frequently Asked Questions
What is clinical trial NCT03042975 about?
NCT03042975 is a clinical study titled "Imaging Genetics of Laryngeal Dystonia". The contribution of genetic risk factors to the development of focal dystonias is evident. However, understanding of how variations in the causative gene expression lead to variations in brain abnormalities in different phenotypes of dystonia (e.g., familial, sporadic) remains limited. The research ...
What is the current status of trial NCT03042975?
This trial is currently recruiting. The enrollment target is 410 participants. The study started on 2017-01-23. Estimated completion is 2028-07-31.
What conditions does trial NCT03042975 study?
This clinical trial studies the following conditions: Laryngeal Dystonia, Muscle Tension Dysphonia, Voice Tremor, Unaffected Relatives of Laryngeal Dystonia Patients.
What interventions are being tested in trial NCT03042975?
The interventions under investigation include: MRI (OTHER), Blood draw (PROCEDURE).
Who is sponsoring clinical trial NCT03042975?
This trial is sponsored by Kristina Simonyan, which has 5 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT03042975 being conducted?
This trial has 1 study location across Massachusetts. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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