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NCT05481411 · ClinicalTrials.gov registry record · Phase 1
A Study to Evaluate the Pharmacokinetics, Safety, and Pharmacodynamics of Olpasiran in Participants With Various Degrees of Hepatic Impairment
A Phase 1 study of Hepatic Impairment, sponsored by Amgen.
- Completed
- Registry status
- Phase 1
- Development phase
- 25
- Enrollment target
- 3
- Study locations
NCT05481411: Completed Phase 1 study of Hepatic Impairment, sponsored by Amgen.
NCT05481411 is a Phase 1 study of Hepatic Impairment that has completed, run by Amgen. The registered enrollment target is 25 participants, below the 36-participant average among 48 other Hepatic Impairment trials with a reported enrollment target (31% lower). The trial reports 3 study locations across 3 states. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT05481411, a Phase 1 study of Hepatic Impairment, has completed, sponsored by Amgen.
- COMPLETED
- Registry status
- Phase 1
- Development phase
- 25 participants
- Enrollment target
- 3
- Study locations
Study Summary
The primary objective of the study is to evaluate the pharmacokinetics (PK) of a single dose of olpasiran in participants with mild, moderate, or severe hepatic impairment compared to participants with normal hepatic function.
Conditions Studied
Interventions
- DRUG Olpasiran
Study Locations (3)
California
- Inland Empire Clinical Trials, LLC - Rialto
Florida
- Orlando Clinical Research Center - Orlando
Texas
- The Texas Liver Institute, Inc. - San Antonio
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 25 participants |
| Start Date | 2022-09-13 |
| Est. Completion | 2023-05-31 |
| Phase | Phase 1 |
What the finished NCT05481411 record still lists
NCT05481411 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 25 participants, a relatively small participant target, below the 36-participant average among 48 other Hepatic Impairment trials with a reported enrollment target (31% lower).
The record links to 1 condition, with Hepatic Impairment appearing as the primary indexed condition, and to 1 intervention - of which Olpasiran is the first listed.
NCT05481411 reports a single indexed study location in California, Florida, Texas.
Frequently Asked Questions
What is clinical trial NCT05481411 about?
NCT05481411 is a clinical study titled "A Study to Evaluate the Pharmacokinetics, Safety, and Pharmacodynamics of Olpasiran in Participants With Various Degrees of Hepatic Impairment". The primary objective of the study is to evaluate the pharmacokinetics (PK) of a single dose of olpasiran in participants with mild, moderate, or severe hepatic impairment compared to participants with normal hepatic function.
What is the current status of trial NCT05481411?
This trial is currently completed. It is a Phase 1 study. The enrollment target is 25 participants. The study started on 2022-09-13. Estimated completion is 2023-05-31.
What conditions does trial NCT05481411 study?
This clinical trial studies the following conditions: Hepatic Impairment.
What interventions are being tested in trial NCT05481411?
The interventions under investigation include: Olpasiran (DRUG).
Who is sponsoring clinical trial NCT05481411?
This trial is sponsored by Amgen, which has 558 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT05481411 being conducted?
This trial has 3 study locations across California, Florida, Texas. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Hepatic Impairment
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT05481411's enrollment target sits among peer trials
25 31st of 48 higher than 17 of 48 other Hepatic Impairment trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Hepatic Impairment trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
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