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CAMPFIRE: A Study of Abemaciclib (LY2835219) in Participants With Ewing's Sarcoma
NCT05440786 · View on ClinicalTrials.gov ↗
Study Summary
The purpose of this study is to measure the benefit of adding abemaciclib to chemotherapy (irinotecan and temozolomide) for Ewing's sarcoma that has come back or did not respond to treatment. This trial is part of the CAMPFIRE master protocol, which is a platform to speed development of new treatments for children and young adults with cancer. Your participation in this trial could last 11 months or longer, depending on how you and your tumor respond.
Conditions Studied
Interventions
- DRUG Temozolomide
- DRUG Abemaciclib
- DRUG Irinotecan
Study Locations (20)
Other
- Charité Campus Virchow-Klinikum — Berlin
- IRCCS Istituto Ortopedico Rizzoli — Bologna
- Kyushu University Hospital — Fukuoka
Victoria
- Peter MacCallum Cancer Centre — Melbourne
- Royal Children's Hospital — Melbourne
Barcelona [Barcelona]
- Hospital Universitari Vall d'Hebron — Barcelona
- Hospital Sant Joan de Déu — Esplugues de Llobregat
Arizona
- Phoenix Children's Hospital — Phoenix
California
- The Regents of the University of California - Los Angeles (UCLA Pediatrics) — Los Angeles
Indiana
- Riley Hospital for Children at Indiana University Health — Indianapolis
Missouri
- Washington University — St Louis
Rhode Island
- Lifespan Cancer Institute — Providence
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 46 participants |
| Start Date | 2022-09-20 |
| Est. Completion | 2028-09 |
| Phase | Phase 2 |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT05440786
The ClinicalTrials.gov registry entry for NCT05440786 describes a study currently listed as active not recruiting. It is categorized as Phase 2, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 46 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Eli Lilly and Company, which has 704 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.
The record links to 2 conditions, with Neoplasm Metastasis appearing as the primary indexed condition, and to 3 interventions — of which Temozolomide is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.
Geographic footprint matters for practical reasons: NCT05440786 reports 20 study locations spanning 16 distinct geographic areas — top geographies include Other, Victoria, Barcelona [Barcelona]. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.
Frequently Asked Questions
What is clinical trial NCT05440786 about?
NCT05440786 is a clinical study titled "CAMPFIRE: A Study of Abemaciclib (LY2835219) in Participants With Ewing's Sarcoma". The purpose of this study is to measure the benefit of adding abemaciclib to chemotherapy (irinotecan and temozolomide) for Ewing's sarcoma that has come back or did not respond to treatment. This trial is part of the CAMPFIRE master protocol, which is a platform to speed development of new treatmen...
What is the current status of trial NCT05440786?
This trial is currently active not recruiting. It is a Phase 2 study. The enrollment target is 46 participants. The study started on 2022-09-20. Estimated completion is 2028-09.
What conditions does trial NCT05440786 study?
This clinical trial studies the following conditions: Neoplasm Metastasis, Sarcoma, Ewing. These conditions were identified from the trial registry and reflect the primary focus areas of the research.
What interventions are being tested in trial NCT05440786?
The interventions under investigation include: Temozolomide (DRUG), Abemaciclib (DRUG), Irinotecan (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.
Who is sponsoring clinical trial NCT05440786?
This trial is sponsored by Eli Lilly and Company, which has 704 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.
Where is trial NCT05440786 being conducted?
This trial has 20 study locations across Arizona, California, Indiana, Missouri, Rhode Island. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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