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NCT05430113 · ClinicalTrials.gov registry record · NA

Spinal Cord Stimulation in Spinal Muscular Atrophy

A NA study of Spinal Muscular Atrophy Type 3 and Spinal Muscular Atrophy Type 4, sponsored by Marco Capogrosso.

Completed
Registry status
NA
Development phase
3
Enrollment target
1
Study location

NCT05430113 is a NA study of Spinal Muscular Atrophy Type 3 and Spinal Muscular Atrophy Type 4 that has completed, run by Marco Capogrosso. The registered enrollment target is 3 participants, below the 95-participant average among 9 other Spinal Muscular Atrophy Type 3 trials with a reported enrollment target (97% lower). The trial reports 1 study location across 1 state.

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The verdict

NCT05430113, a NA study of Spinal Muscular Atrophy Type 3 and Spinal Muscular Atrophy Type 4, has completed, sponsored by Marco Capogrosso.

COMPLETED
Registry status
NA
Development phase
3 participants
Enrollment target
1
Study location

Study Summary

Spinal cord stimulation (SCS) has shown remarkable efficacy in restoring motor function in people with spinal cord injury by recruiting afferent input to enhance the responsiveness of spared neural circuits to residual cortical inputs. This pilot will test if SCS can show evidence to improve motor deficits in people with type 3 or 4 spinal muscular atrophy (SMA). The investigators will enroll up to six subjects with Type 3 or 4 SMA aged 16 or older that show quantifiable motor deficits of the legs but are able to stand independently. The investigators will then implant the subjects with percutaneous, bilateral, linear spinal leads near the lumbar spinal cord for a period of up to 29 days. Although these leads are not optimized for motor function but rather for their clinically approved indication of treating pain, the investigators believe they provide a safe technology enabling our team to perform scientific measurement necessary to evaluate potential for effects of SCS in motor paralysis with SMA. After the end of the study, the leads will be explanted.

Conditions Studied

Spinal Muscular Atrophy Type 3 Spinal Muscular Atrophy Type 4

Interventions

  • DEVICE Spinal Cord Stimulator (octopolar Medtronic Vectris Leads)

Study Locations (1)

Pennsylvania

  • University of Pittsburgh - Pittsburgh

Trial Details

FieldValue
Enrollment Target 3 participants
Start Date 2022-04-05
Est. Completion 2025-01-13
Phase NA

Sponsor

Marco Capogrosso

3 total trials

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What the Registry Record Tells You About NCT05430113

The ClinicalTrials.gov registry entry for NCT05430113 describes a study currently listed as completed, categorized as NA. The registered enrollment target is 3 participants, a figure that helps gauge the scale of data the investigators plan to collect, below the 95-participant average among 9 other Spinal Muscular Atrophy Type 3 trials with a reported enrollment target (97% lower). The listed sponsor is Marco Capogrosso, which has 3 total studies on file at ClinicalTrials.gov.

The record links to 2 conditions, with Spinal Muscular Atrophy Type 3 appearing as the primary indexed condition, and to 1 intervention - of which Spinal Cord Stimulator (octopolar Medtronic Vectris Leads) is the first listed.

NCT05430113 reports 1 study location spanning 1 distinct geographic area - top geographies include Pennsylvania.

Frequently Asked Questions

What is clinical trial NCT05430113 about?

NCT05430113 is a clinical study titled "Spinal Cord Stimulation in Spinal Muscular Atrophy". Spinal cord stimulation (SCS) has shown remarkable efficacy in restoring motor function in people with spinal cord injury by recruiting afferent input to enhance the responsiveness of spared neural circuits to residual cortical inputs. This pilot will test if SCS can show evidence to improve motor d...

What is the current status of trial NCT05430113?

This trial is currently completed. It is a NA study. The enrollment target is 3 participants. The study started on 2022-04-05. Estimated completion is 2025-01-13.

What conditions does trial NCT05430113 study?

This clinical trial studies the following conditions: Spinal Muscular Atrophy Type 3, Spinal Muscular Atrophy Type 4.

What interventions are being tested in trial NCT05430113?

The interventions under investigation include: Spinal Cord Stimulator (octopolar Medtronic Vectris Leads) (DEVICE).

Who is sponsoring clinical trial NCT05430113?

This trial is sponsored by Marco Capogrosso, which has 3 total clinical trials registered on ClinicalTrials.gov.

Where is trial NCT05430113 being conducted?

This trial has 1 study location across Pennsylvania. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

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Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page mirrors this trial's own ClinicalTrials.gov registry record, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.